Prevalence of <i>Trypanosoma cruzi</i>, the Etiologic Agent of Chagas Disease, Infection in Texas Skunks (Mammalia: Mephitidae)

Gulas-Wroblewski, Bonnie E.; Gorchakov, Rodion; Kairis, Rebecca B.; Dowler, Robert C.; Murray, Kristy O.

doi:10.1089/vbz.2022.0056

Vector-Borne and Zoonotic Diseases

2023

DOI: 10.1089/vbz.2022.0056

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Prevalence of Trypanosoma cruzi, the Etiologic Agent of Chagas Disease, Infection in Texas Skunks (Mammalia: Mephitidae)

Bonnie E. Gulas-Wroblewski

Rodion Gorchakov

Rebecca B. Kairis

et al.

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2024

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Cited by 2 publications

References 85 publications

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Bartonella rochalimae in a flea collected from a Mephitis macroura in Sonora Mexico

Fernández-González,

Herrera-Mares,

Ramírez-Corona

et al. 2024

Acta Parasit.

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Purpose At least thirty species of wild carnivores have been recorded harboring Bartonella, and one of the most common pathogenic species infecting them is Bartonella rochalimae, which can cause endocarditis in humans and dogs. This bacterium can infect various mammals including wild carnivores, as well as ectoparasitic vectors such as fleas and ticks. Here we report the presence of B. rochalimae, in a Pulex simulans flea collected from a Mephitis macroura skunk in the municipality of Santa Cruz in Sonora, Mexico. Methods Fleas were collected from a M. macroura in Sonora, Mexico, in October 2019. They were identified to species level and subsequently tested for the presence of Bartonella using molecular tools including conventional PCR, sequencing, and phylogenetic analysis. Results A total of 10 P. simulans fleas (one male, nine females) were collected from the M. macroura skunk. The PCR and phylogenetic analysis indicated a prevalence of 10% (1/10) and a sequence clustered with the clade of B. rochalimae. Conclusions We confirmed the presence of B. rochalimae in a P. simulans flea collected from a M. macroura skunk in the area of Santa Cruz, Sonora, Mexico. Based on our results and previous studies in northern Mexico, which are consistent, it is necessary to continue monitoring Bartonella in M. macroura skunks and their fleas, since they could be important reservoirs of this bacterium in northern Mexico.

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Bartonella rochalimae in a flea collected from a Mephitis macroura in Sonora Mexico

Fernández-González,

Herrera-Mares,

Ramírez-Corona

et al. 2024

Acta Parasit.

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Animal models for exploring Chagas disease pathogenesis and supporting drug discovery

Khan,

Taylor,

Fortes Francisco

et al. 2024

Clin Microbiol Rev

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SUMMARY Infections with the parasitic protozoan Trypanosoma cruzi cause Chagas disease, which results in serious cardiac and/or digestive pathology in 30%–40% of individuals. However, symptomatic disease can take decades to become apparent, and there is a broad spectrum of possible outcomes. The complex and long-term nature of this infection places a major constraint on the scope for experimental studies in humans. Accordingly, predictive animal models have been a mainstay of Chagas disease research. The resulting data have made major contributions to our understanding of parasite biology, immune responses, and disease pathogenesis and have provided a platform that informs and facilitates the global drug discovery effort. Here, we provide an overview of available animal models and illustrate how they have had a key impact across the field.

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Prevalence of Trypanosoma cruzi, the Etiologic Agent of Chagas Disease, Infection in Texas Skunks (Mammalia: Mephitidae)

Cited by 2 publications

References 85 publications

Bartonella rochalimae in a flea collected from a Mephitis macroura in Sonora Mexico

Bartonella rochalimae in a flea collected from a Mephitis macroura in Sonora Mexico

Animal models for exploring Chagas disease pathogenesis and supporting drug discovery

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