Prevalence of iatrogenic admissions to the Departments of Medicine/Cardiology/ Pulmonology in a 1,250 bed general hospital

Atiqi, Roya; Bommel, Eric van; Cleophas, Ton J.; Zwinderman, A. H.

doi:10.5414/cpp48517

Cited by 20 publications

(12 citation statements)

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“…However, it is possible to make estimates from previous publications related to iatrogenic disease. A recent meta-analysis showed the incidence of iatrogenic disease to be between 3.4% and 33.9% 4. In 1998, Darchy et al5 reported that of 623 patients admitted to the intensive care unit, 68 (10.9%) were considered to be iatrogenic cases.…”

Section: Epidemiologymentioning

confidence: 99%

“…Atiqi et al reassessed the prevalence of iatrogenic admissions reported in a study done by internists 4. Most often, iatrogenic admissions were observed with cardiac disease, hypertension, gastrointestinal conditions, anticoagulant treatment, and use of nonsteroidal anti-inflammatory drugs.…”

Section: Epidemiologymentioning

confidence: 99%

“…The word “iatrogeny” derives from Greek and refers to any pathologic alteration caused to a patient by the inappropriate practice of health professionals, which results in harmful consequences for the patient’s health 3. According to the World Health Organisation, iatrogenic disease may be defined as adverse drug reactions or complications induced by nondrug medical interventions 4. In addition, iatrogenic disease has been defined by Darchy et al5 as a disease induced by a drug prescribed by a physician, after a medical or surgical procedure (excluding intentional overdose, nonmedical intervention) unauthorized prescription, and environmental events (eg, falls, defective equipment).…”

Section: Introductionmentioning

confidence: 99%

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Iatrogenic disease in the elderly: risk factors, consequences, and prevention

Permpongkosol¹

2011

CIA

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The epidemiology of iatrogenic disease in the elderly has not been extensively reported. Risk factors of iatrogenic disease in the elderly are drug-induced iatrogenic disease, multiple chronic diseases, multiple physicians, hospitalization, and medical or surgical procedures. Iatrogenic disease can have a great psychomotor impact and important social consequences. To identify patients at high risk is the first step in prevention as most of the iatrogenic diseases are preventable. Interventions that can prevent iatrogenic complications include specific interventions, the use of a geriatric interdisciplinary team, pharmacist consultation and acute care for the elderly units.

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Section: Epidemiologymentioning

confidence: 99%

Section: Epidemiologymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Iatrogenic disease in the elderly: risk factors, consequences, and prevention

Permpongkosol¹

2011

CIA

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“…While most documentation of the problem has focused on DRVs attributed to adverse drug reactions (ADRs), few researchers have explored other drug-related problem (DRP) etiologies categorized within the pharmaceutical care nosology, including inappropriate medication selection or dosing; untreated symptoms or disease; drug interactions; and patient non-adherence [1]–[5]. Features of patient populations at-risk for DRVs have been consistently described (the elderly, those with impaired cognition, dependent living situations, renal insufficiency, multiple comorbidities or polypharmacy) as have the most common offending therapies (antiplatelets, anticoagulants, non-steroidal anti-inflammatory drugs (NSAIDS), diuretics, angiotensin converting enzyme (ACE) inhibitors, opioids, and diabetes treatments) [6]–[8].…”

Section: Introductionmentioning

confidence: 99%

Drug-Related Hospital Visits and Admissions Associated with Laboratory or Physiologic Abnormalities—A Systematic-Review

2013

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Countless studies have demonstrated that many emergency-room visits and hospital admissions are drug-related and that a significant proportion of these drug-related visits (DRVs) are preventable. It has not been previously studied which DRVs could be prevented through enhanced monitoring of therapy. The objective of the study was to determine the incidence of DRVs attributed to laboratory or physiologic abnormalities. Three authors independently performed comprehensive searches in relevant health care databases using pre-determined search terms. Articles discussing DRV associated with poisoning, substance abuse, or studied among existing in-patient populations were excluded. Study country, year, sample, design, duration, DRV identification method, proportion of DRVs associated with laboratory or physiologic abnormalities and associated medications were extracted. The three authors independently assessed selected relevant articles according to the Strengthening the reporting of observational studies in epidemiology (STROBE) as applicable according to the studies' methodology. The initial literature search yielded a total of 1,524 articles of which 30 articles meeting inclusion criteria and reporting sufficient laboratory or physiologic data were included in the overall analysis. Half employed prospective methodologies, which included both chart review and patient interview; however, the overwhelming majority of identified studies assessed only adverse drug reactions (ADRs) as a drug-related cause for DRV. The mean (range) prevalence of DRVs found in all studies was 15.4% (0.44%–66.7%) of which an association with laboratory or physiologic abnormalities could be attributed to a mean (range) of 29.4% (4.3%–78.1%) of cases. Most laboratory-associated DRVs could be linked to immunosuppressant, antineoplastic, anticoagulant and diabetes therapy, while physiologic-associated DRVs were attributed to cardiovascular therapies and NSAIDs. Significant proportions of laboratory and physiologic abnormalities contribute to DRVs and are consistently linked to specific drugs. These therapies are potential targets for enhanced medication monitoring initiatives to proactively avert potential DRVs.

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“…[1][2][3] They generate preventable emergency department visits and hospital admissions, prolong hospital stays, and increase health care costs. [1][2][3][4][5][6][7] Providers often fail to recognize ADRs quickly enough or at all. 1,2 As new drugs become available and patients take more medications, providers will face increasing challenges in recognizing their patients' ADRs.…”

Section: Background and Significancementioning

confidence: 99%