Prevalence of IgA-Antigliadin Antibodies and IgA-Antiendomysium Antibodies Related to Celiac Disease in Children With Down Syndrome

Abstract

Objective. This study was undertaken to investigate the prevalence of celiac disease in children and adolescents with Down syndrome.Material and Methods. Forty-three children and adolescents with Down syndrome were screened for IgAantigliadin antibodies (AGA) and IgA-antiendomysium antibodies (EMA). Patients found to be either AGA-or EMA-positive were investigated further with intestinal biopsy.Results. None of the 43 patients had known celiac disease at entry into the study; 37% (16/43) were found to have AGA levels above normal, and 16% (7/43) to be EMA-positive. Of the 15 patients who underwent biopsy, 8 manifested villous atrophy. Villous atrophy was present in all 7 of the EMA-positive patients, whereas the villi were normal in 7 of the 13 AGA-positive patients who underwent biopsy.Conclusions. EMA is a good immunologic marker for use in screening for celiac disease, and screening is justified in patients with Down syndrome. Pediatrics 1998; 101:272-275; Down syndrome, celiac disease, IgA-antigliadin antibodies, IgA-antiendomysium antibodies.

The relation between the psychological functioning of children with Down syndrome and their urine peptide levels and levels of serum antibodies to food proteins

“…This report shows that children with Down syndrome have increased levels of antibodies to food proteins, and thus confi rms earlier fi ndings (Kanavin et al, 1988;Reichelt KL et al, 1994;Bonamico et al, 1996;Failla et al, 1996;George et al, 1996;Gale et al, 1997;Carlsson et al, 1998). No studies have investigated whether siblings also have increased levels of serum antibodies to food proteins.…”

“…As Marsh (1995, p.12) stated, "gluten sensitivity should be considered as a state of heightened immunological responsiveness (T-and B-cell-based) to ingested gluten proteins in genetically-predisposed individuals". It is also important to remember that the frequency of celiac disease in people with Down syndrome is much higher than in the general population (Failla et al, 1996;George et al, 1996;Gale et al, 1997;Morris et al, 1997;Carlsson et al, 1998). A connection between gluten sensitivity and neurological disorders has been reported for patients with celiac disease (Gobbi et al, 1992;Kinney et al, 1982;Cooke & Smith, 1966;Bhatia et al, 1995), as well as for patients with neurological dysfunction of unknown cause (Gobbi et al, 1992;Hadjiwassiliou et al, 1996).…”

“…Increased serum levels of antibodies to food proteins in people with Down syndrome (Kanavin et al, 1988;Reichelt KL et al, 1994;Bonamico et al, 1996;Failla et al, 1996;George et al, 1996;Gale et al, 1997;Carlsson et al, 1998), point to an increased transmucosal uptake of proteins from the gut (Scott et al, 1984). Increased uptake of proteins combined with peptidase defi ciencies would result in hyperpeptidaemia and usually hyperpeptiduria.…”

Curvas padrão pôndero-estatural de portadores de Síndrome de Down procedentes da região urbana da cidade de São Paulo

“…Essas anomalias ocorrem em cerca de 3 a 7,5%, entre as quais doença celíaca (BONAMICO et al, 1996;SACHETTI et al, 1996;CARLSSON et al, 1998; e megacólon (doença de Hirshprungaganglionose em 2% de SD) relacionam-se com síndromes de má absorção.…”

Celiac Disease Prevalence in the Patients with Irritable Bowel Syndrome in the Ilam Province; A Cross Sectional Study from Western Iran

“…Many studies have shown the prevalence of CD is increasing among the patient with), Down syndrome [3,7], type 1 of diabetes [8,9], IgA deficiency [10], Turner syndrome [11], Williams syndrome [12] and auto immune thyroiditis [13]. CD can be appeared with the similar signs of the IBS such as diarrhea and constipation or other changes in the defecation 14,15].…”