Prevalence of IgM and IgG antibodies to West Nile virus among blood donors in an affected area of north-eastern Italy, summer 2009

Pezzotti, Patrizio; Piovesan, Cinzia; Barzon, Luisa; Cusinato, Riccardo; Cattai, Margherita; Pacenti, Monia; Piazza, Antida; Franchin, Elisa; Pagni, Silvana; Bressan, Silvia; Martello, Thomas; Potenza, R; Scipioni, Cinzia; Ammendola, Rosario; Breda, Alex van; Palù, Giorgio; Russo, Federico; Rezza, Giovanni

doi:10.2807/ese.16.10.19814-en

Cited by 20 publications

(24 citation statements)

References 31 publications

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“…West Nile Virus (WNV) is a member of the flaviviridae family and genus Flavivirus, transmitted by Culex mosquito species 1,2 . Birds are its natural host and they play a major role in the geographic dispersion of the virus.…”

Section: Introductionmentioning

confidence: 99%

“…Plaque Reduction Neutralization Test (PRNT) was not done. This could have inflated the seropositivity for WNV since the cross reactivity of arboviruses was not taken into consideration, although another similar study which carried out the PRNT following the primary test showed that about 80% of the primary results were confirmed 1 . The other limitation could be the fact that the association of WNV and the veterinary and avian populations which exist in the provinces was not done.…”

mentioning

confidence: 99%

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Seroprevalence of West Nile Virus specific IgG and IgM antibodies in North-Western and Western provinces of Zambia

Mweene-Ndumba¹,

Siziya²,

Monze³

et al. 2015

Afr H. Sci.

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Background: West Nile Virus (WNV) infection has been reported worldwide, including in Africa but its existence in Zambia is unknown. Symptoms for the virus include headache, myalgia, arthralgia and rash. Objectives: This study aimed to determine the seroprevalence of WNV and its correlates. Methods: A cross sectional study was conducted in North-Western and Western provinces of Zambia. Samples were subjected to IgG and IgM antibodies testing against WNV. Logistic regression analyses were conducted to determine magnitudes of association. Conclusion: Spraying houses with insecticide residual spray would minimize mosquito-man contact. Furthermore, surveillance at the border with Angola should be enhanced in order to reduce importation of the virus into the country.

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Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

Seroprevalence of West Nile Virus specific IgG and IgM antibodies in North-Western and Western provinces of Zambia

Mweene-Ndumba¹,

Siziya²,

Monze³

et al. 2015

Afr H. Sci.

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“…In the following years, cases of WNND were diagnosed in a larger area near the Po river [28,29,30], while sero-prevalence studies in blood and organ donors [31,32] and veterinary and entomological investigation indicated viral activity also in other regions [33]. This led the Italian Ministry of Health to publish in 2010 a national plan for WNND human surveillance that integrated veterinary and vector surveillance [13].…”

Section: Introductionmentioning

confidence: 99%

Large Human Outbreak of West Nile Virus Infection in North-Eastern Italy in 2012

Barzon

Pacenti

Franchin

et al. 2013

Viruses

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Human cases of West Nile virus (WNV) disease have been reported in Italy since 2008. So far, most cases have been identified in north-eastern Italy, where, in 2012, the largest outbreak of WNV infection ever recorded in Italy occurred. Most cases of the 2012 outbreak were identified in the Veneto region, where a special surveillance plan for West Nile fever was in place. In this outbreak, 25 cases of West Nile neuroinvasive disease and 17 cases of fever were confirmed. In addition, 14 WNV RNA-positive blood donors were identified by screening of blood and organ donations and two cases of asymptomatic infection were diagnosed by active surveillance of subjects at risk of WNV exposure. Two cases of death due to WNND were reported. Molecular testing demonstrated the presence of WNV lineage 1 in all WNV RNA-positive patients and, in 15 cases, infection by the novel Livenza strain was ascertained. Surveillance in other Italian regions notified one case of neuroinvasive disease in the south of Italy and two cases in Sardinia. Integrated surveillance for WNV infection remains a public health priority in Italy and vector control activities have been strengthened in areas of WNV circulation.

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“…The lack of surveillance in both animals and humans in the rural areas where the virus re‐emerged did not allow an accurate map to be made of West Nile virus circulation foci. This would have allowed the prediction of future outbreaks and an assessment of the risk of disease transmission through blood transfusion, although recent studies showed that blood donors living in risk areas should be systematically tested for West Nile virus infection (Pezzotti et al., ; Papa et al., ). In addition, the screening of sentinel wild bird species proved to be effective for identifying circulation areas (Jourdain et al., ).…”

Section: Socio‐economic Factorsmentioning

confidence: 99%

Risks of Emerging Infectious Diseases: Evolving Threats in a Changing Area, the Mediterranean Basin

Vittecoq

Thomas

Jourdain

et al. 2012

Transbound Emerg Dis

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The Mediterranean basin is a biodiversity hotspot; it has historically had a large human presence that has shaped ecosystems for millennia. As the cradle of many civilizations, the area was one of the main theatres for transitions that punctuated both human and pathogen histories, which are intimately linked. Today we are living through another great historical transition summarized in the expression 'global changes'. In this context, we are witnessing a rise in the emergence of pathogens widely associated with aforementioned global changes. The Mediterranean basin might be especially vulnerable to this phenomenon due to the acute consequences global changes will have in this key intercontinental interface region. In addition, Arab revolutions and European economic crisis are creating both sanitary issues and presenting new opportunities to improve infectious disease control and prevention in the region. The aim of this review is to identify the impacts that ongoing changes might have on the risk of infectious disease emergence in the Mediterranean basin. We focussed on three key domains undergoing transformations: (i) resources, namely safe drinking water and animal products, (ii) socio-economic factors including health inequalities within countries and poor sanitary conditions linked to ongoing conflicts and (iii) movements of people and goods that are reshaped by current changes and are intimately linked to the risk of disease proliferation. Building on recent examples, we try to identify upcoming challenges and discuss ways to meet them in the light of existing international human and veterinary health guidelines and their possible improvements.

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Prevalence of IgM and IgG antibodies to West Nile virus among blood donors in an affected area of north-eastern Italy, summer 2009

Abstract: Binary file ES_Abstracts_Final_ECDC.txt matches

Cited by 20 publications

References 31 publications

Seroprevalence of West Nile Virus specific IgG and IgM antibodies in North-Western and Western provinces of Zambia

Seroprevalence of West Nile Virus specific IgG and IgM antibodies in North-Western and Western provinces of Zambia

Large Human Outbreak of West Nile Virus Infection in North-Eastern Italy in 2012

Risks of Emerging Infectious Diseases: Evolving Threats in a Changing Area, the Mediterranean Basin

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