Prevalence of infection with high-risk human papillomavirus in women in Colombia

Camargo, Milena; Sánchez, Ricardo; León, Sara Cecilia Soto-De; Urquiza, Mauricio; Acosta, J.; Monsalve, Diana M.; Rodrı́guez, Luis E.; Patarroyo, Manuel Elkín; Patarroyo, Manuel A.

doi:10.1111/j.1469-0691.2008.02120.x

Cited by 13 publications

(12 citation statements)

References 16 publications

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“…Previous research conducted in Colombia using a single primer set (GP5+/6+) to estimate HPV-DNA prevalence in patients having normal cytology has reported positive findings in 14.8% of its sample (Molano et al, 2002). 49.2% prevalence was detected later in cytology samples during 2009 using two different primers sets (GP5+/6+ and MY09/11) (Soto-De Leon et al, 2009), similar to that being reported now using three primers sets (55.2%).…”

Section: Discussionsupporting

confidence: 77%

The diagnostic performance of classical molecular tests used for detecting human papillomavirus

Muñoz

Camargo

Leon

et al. 2012

Journal of Virological Methods

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Section: Discussionsupporting

confidence: 77%

The diagnostic performance of classical molecular tests used for detecting human papillomavirus

Muñoz

Camargo

Leon

et al. 2012

Journal of Virological Methods

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“…Of the total number of infected women, 65.2% (CI 95%: 62%–68.3%) were infected with multiple HPV types. A previous study on this population had found that infections with multiple HR-HPV types are more frequently associated with types belonging to the A7 species [14]. Compared to expected frequencies and assuming a Negative Binomial distribution, the observed number of women having a single infection (one HPV type) was significantly smaller than expected.…”

Section: Resultscontrasting

confidence: 55%

“…These five populations have been described elsewhere [14]. Prior to undergoing gynecological examination, all women signed a written informed consent and filled out a questionnaire regarding sociodemographic characteristics, sexual behaviors and risk factor data (Table 1).…”

Section: Methodsmentioning

confidence: 99%

Distribution Patterns of Infection with Multiple Types of Human Papillomaviruses and Their Association with Risk Factors

et al. 2011

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BackgroundInfection with multiple types of human papillomavirus (HPV) is one of the main risk factors associated with the development of cervical lesions. In this study, cervical samples collected from 1,810 women with diverse sociocultural backgrounds, who attended to their cervical screening program in different geographical regions of Colombia, were examined for the presence of cervical lesions and HPV by Papanicolau testing and DNA PCR detection, respectively.Principal FindingsThe negative binomial distribution model used in this study showed differences between the observed and expected values within some risk factor categories analyzed. Particularly in the case of single infection and coinfection with more than 4 HPV types, observed frequencies were smaller than expected, while the number of women infected with 2 to 4 viral types were higher than expected. Data analysis according to a negative binomial regression showed an increase in the risk of acquiring more HPV types in women who were of indigenous ethnicity (+37.8%), while this risk decreased in women who had given birth more than 4 times (−31.1%), or were of mestizo (−24.6%) or black (−40.9%) ethnicity.ConclusionsAccording to a theoretical probability distribution, the observed number of women having either a single infection or more than 4 viral types was smaller than expected, while for those infected with 2–4 HPV types it was larger than expected. Taking into account that this study showed a higher HPV coinfection rate in the indigenous ethnicity, the role of underlying factors should be assessed in detail in future studies.

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“…The prevalence of multiple HPV infection has been reported in a range that varies from 54.0% to 78.9% [21,46,[54][55][56]. Our results fall within this range.…”

Section: Discussionsupporting

confidence: 78%

Prevalence of Human Papillomavirus (HPV) Genotypes and Multiple Infections in Routine Cervical Cancer Screening in a Spanish Regional Population

Méndez¹

2013

SOJ Microbiol Infect Dis

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BackgroundCervical cancer is the second most common cancer in women worldwide and the most common cause of mortality in underdeveloped and developing countries [1,2]. Persistent infection with certain oncogenic high-risk (HR) types of Human Papillomavirus (HPV) is the required factor for the development of invasive cervical cancer and precursor lesions [3][4][5][6].Overall, the prevalence and distribution of HPV infection in cervical lesions has been determined in many geographical regions of the world, this can vary depending on several factors including epidemiological differences in the populations studied and the methodology used for molecular detection and typing of HPV DNA [7]. Over 120 types of HPV have been classified as either low (LR-HPV) or high risk (HR-HPV), according to their oncogenic potential [8,9]. Within the high-risk genotypes, HPV types 16 and HPV 18 are most often associated with cancer and squamous intraepithelial lesion [5,6,10,11,12]. Nevertheless, the risk of neoplasia for other types of HPV as well as for multiple HPV infection has not yet been established.Because current strategies for the prevention of cervical cancer and their precancerous lesions are based on the HPV genotyping [13] and prophylactic vaccines [14][15][16], it seems necessary to determine the types of HPV most commonly associated with malignant cell transformation in different geographical areas in order to establish effective preventive measures according to the epidemiology of the population. This study was to know the prevalence and distribution of cervical HPV infection in women attending routine cervical cancer screening in the Valencia region (Spain). Study designLiquid-based cytology (LBC) of cervical specimens was collected during routine screening visits, between June 20, 2011 and September 9, 2011 in the Clinical Hospital of Valencia, Spain. LBC samples were processed using the Thin Prep® 5000 processor (Madrid, Spain). For HPV detection and genotyping, we used the residual cervical sample material available from the same Thin Prep Pap test vial previously used for cytological screening. DNA was extracted from the residual materials of LBC by QIAamp® DNA mini kit (IZASA, Valencia, Spain), according to the manufacturer's instructions. HPV testing was performed by INNO-Lipa HPV genotyping Extra Reverse Hybridization Line Probe Assay kit (Innogenetics®, Barcelona, Spain), according to the manufacturer's instructions. Briefly, HPV detection and genotyping was based on PCR amplification of a 65pb fragment, within the L1 region of the HPV genome, using broad-spectrum SPF10 biotinylated primers. PCR was performed in a final AbstractBackground: Infection with human papillomavirus (HPV) has been identified as the primary cause of cervical cancer. Persistent infection with high risk-HPV is the required factor for the development of cervical cancer.

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Prevalence of infection with high-risk human papillomavirus in women in Colombia

Cited by 13 publications

References 16 publications

The diagnostic performance of classical molecular tests used for detecting human papillomavirus

The diagnostic performance of classical molecular tests used for detecting human papillomavirus

Distribution Patterns of Infection with Multiple Types of Human Papillomaviruses and Their Association with Risk Factors

Prevalence of Human Papillomavirus (HPV) Genotypes and Multiple Infections in Routine Cervical Cancer Screening in a Spanish Regional Population

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