Prevalence of inflammatory bowel disease in Japanese psoriatic patients

Abstract

Psoriatic patients reportedly have a higher prevalence of inflammatory bowel disease (IBD); however, there have been few research studies of Japanese psoriatic patients. To elucidate the prevalence of IBD in Japanese psoriatic patients, a cross‐sectional study was performed. Information was collected regarding psoriatic patients with current or prior history of Crohn's disease (CD) or ulcerative colitis (UC) who were treated at Fukuoka University Hospital from 2010 to 2018. Among 681 psoriatic patients (449 men and 232 women), eight (1.2%, six men, two women) had UC and two (0.3%, one man, one woman) had CD. Diagnosis of IBD preceded psoriasis in five patients, while diagnosis of psoriasis preceded IBD in two; the remaining patients’ records did not have sufficient information. Seven of 10 UC‐positive patients had mild psoriasis, two had moderate psoriasis and one had severe psoriasis. When UC‐positive psoriatic patients were compared with IBD‐negative psoriatic patients, there were no differences in age at onset of psoriasis, age at first visit or complications (e.g. psoriatic arthritis, hypertension, hyperlipidemia, hyperuricemia and diabetes). However, UC‐positive patients had significantly higher body mass index (BMI) (26.7 vs 23.7; P = 0.021), compared with patients without IBD. The CD/UC ratio in this cohort was 0.25, while the prevalence of IBD was 1.2%; these values were both lower than those in previous reports involving Caucasian patients. Patients with psoriasis and UC may have higher BMI and milder skin symptoms than those with psoriasis alone. These observations must be further confirmed by controlled domestic studies with larger samples.

Epidemiology of Psoriasis and Comorbid Diseases: A Narrative Review

“…Psoriasis patients were reported to have a higher prevalence of gastrointestinal signs and symptoms (feeling full/ bloated, belly pain, diarrhea, mucus/blood in stool, and unintentional weight loss) (121), and sex and PsA were particular risk factors (122). Psoriasis-UC patients may have a higher BMI and milder skin symptoms than those with psoriasis alone (123), while psoriasis-CD patients have a mild (earlyonset) psoriasis but a severe CD phenotype (124). While a cohort study in Denmark found a limited incremental effect of IBDs on risk of comorbidities in patients with psoriasis (125).…”

Aryl Hydrocarbon Receptor in Atopic Dermatitis and Psoriasis

“…The cosmetic disfigurement associated with psoriasis profoundly impairs the patients’ quality of life, treatment satisfaction and adherence, and socioeconomic stability [114,115]. The autoimmune nature of psoriasis is exemplified by its high comorbidity with psoriatic arthritis [110,116,117,118] and other autoimmune diseases including autoimmune bullous diseases [119,120,121,122,123,124]. Psoriasis is also comorbid with cardiovascular diseases, metabolic diseases, and renal disorders, which represent a condition called inflammatory skin march [111,125,126,127,128,129].…”

Pathogenic implication of epidermal scratch injury in psoriasis and atopic dermatitis

“…30,33 Psoriasis is considered as an autoimmune or autoinflammatory disease with high rate of comorbidities, including psoriatic arthritis 30,[34][35][36] and other autoimmune diseases such as autoimmune bullous diseases. 32,[37][38][39][40] Comorbid conditions of psoriasis further comprise cardiovascular diseases, metabolic diseases and renal disorders, collectively called the inflammatory skin march. 41,42 Histopathologically, psoriasis is characterized by epidermal hyperproliferation, intraepidermal neutrophilic infiltration and dermal inflammatory cell infiltration.…”