Prevalence of Inflammatory Bowel Disease in Pediatric and Adult Populations: Recent Estimates From Large National Databases in the United States, 2007–2016

Abstract

Background The latest estimate of the prevalence of inflammatory bowel disease (IBD) in the United States was based on 2009 data, which indicates a need for an up-to-date re-estimation. The objectives of this study were to investigate the prevalence of all forms of IBD including ulcerative colitis (UC), Crohn’s disease (CD), and IBD unspecified (IBDU). Methods Pediatric (age 2–17) and adult (age ≥18) IBD patients were identified from 2 large claims databases. For each year between 2007 and 2016, prevalence was calculated per 100,000 population and standardized based on the 2016 national Census. A fixed-effects meta-analytical model was used for overall prevalence. Results The pediatric prevalence of IBD overall increased by 133%, from 33.0/100,000 in 2007 to 77.0/100,000 in 2016. Among children, CD was twice as prevalent as UC (45.9 vs 21.6). Prevalence was higher in boys than girls for all forms of IBD, in contrast to the adult population where the prevalence was higher in women than men. We also found that the 10–17 age subgroup was the major contributor to the rising pediatric IBD prevalence. For adults, the prevalence of IBD overall increased by 123%, from 214.9 in 2007 to 478.4 in 2016. The prevalence rates of UC and CD were similar (181.1 vs 197.7) in 2016. Conclusions Inflammatory bowel disease continues to affect a substantial proportion of the US population. In 2016, 1 in 209 adults and 1 in 1299 children aged 2–17 were affected by IBD. Prevalence of IBD has been increasing compared with previously published 2009 data.

Identifying Patients With Inflammatory Bowel Diseases in an Administrative Health Claims Database: Do Algorithms Generate Similar Findings?

“…In the area of observational research, we know that prevalence estimates are a cornerstone of health epidemiology and can provide critical RWE that impacts numerous aspects of the health care decision-making process. 21,22 The number of patients with IBDU found by each algorithm may relate to newly developed or incident cases of IBD, which may explain the lack of clarity around official diagnoses. Equally, patients with confirmed diagnoses of CD or UC may feature in the number of IBD patients.…”

Ulcerative Colitis in A Nigerian – A Case Report

“…Ulcerative colitis is more common in the Western and Northern hemispheres; the incidence is low in Asia and the Far East [2] . In the United States adult population (18years and above), the overall prevalence of Inflammatory bowel disease was 478.4 per 100,000 people in 2016; the prevalence rates of Ulcerative Colitis and Crohn's Disease were 181.1 per 100,000 people and 197.7 per 100,000 people respectively [3] . Ulcerative colitis is reportedly rare in Black Africans [4,5] and indeed Nigerians [6,7,8] compared to Western populations [9,10,11] .…”

Inflammatory bowel disease: Therapeutic limitations and prospective of the stem cell therapy

“…An estimated 1.3% of US adults (approximately 3 million) are currently diagnosed with IBD and approximately 70000 new cases are being added each year[ 3 ]. Moreover, the incidences of IBD especially in young adults and children are constantly increasing[ 4 , 5 ]. In sum total, if effective and safe preventive measures are not taken, and anti-IBD therapies are not developed on an urgent basis, IBD incidences and associated risk of colorectal cancer in young adults will reach to an epic proportion in the near future[ 6 ].…”

“…However, the above statistics does not include the pediatric incidence and/or prevalence of IBD (18 years or younger) and when combined together, the overall number would obviously be far higher. In this regard, according to a relatively recent report, the pediatric IBD prevalence increased by 133%, from 33/100000 in 2007 to 77/100000 in 2016[ 4 , 5 ]. Also, it appears that a disparity exists between pediatric UC vs CD incidence as the disease increase at an almost 2-fold higher rate (45.9 vs 21.6 for CD vs UC respectively).…”

“…Moreover, in the adult population IBD prevalence seems higher in women than in men though the values have not been statistically different. Overall, available statistics suggest a constant increase in IBD incidences especially in the age group younger than 18 years[ 5 ].…”