Prevalence of Kawasaki Disease in Children Admitted to Taleghani Medical Center in Gorgan, Iran

Cheraghali, Fatemeh; Hajimoradloo, Naghimeh; Roshandel, Gholamreza; Meftah, Mehrnaz; Azadfar, Somayeh

doi:10.29252/jcbr.2.4.54

Cited by 4 publications

(10 citation statements)

References 11 publications

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“…The most common clinical presentation of KD was rash (seen in 62% of patients), oral mucosa and lip involvement (58%), and extremity changes (58%). Our ndings were similar to the ndings of Cheraghali F et al [17] introducing skin rash (68.6%) and changes of the lip and oropharyngeal mucosa (60.8%) as the most common manifestations of KD, but were slightly different from Pilania R.K. et al which showed oral cavity and lips' changes as the most common manifestation (> 95%) of KD, and rash as the second (> 90%). Furthermore, our results showed that neck lymphadenopathy was the least common clinical nding that is compatible with Pilania R.K. et al) [18].…”

Section: Discussionsupporting

confidence: 89%

Effect of COVID-19 on Kawasaki Disease: Decrease Age of Onset and Increase Skin Manifestation

Esmaeilzadeh

Mortazavi

Salehi

et al. 2021

Preprint

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Kawasaki Disease (KD) is most common childhood vasculitis and cause of acquired heart disease for no apparent reason. There is some evidence indicating infectious agents as possible triggers for KD. During the COVID-19 pandemic, vasculitis has been a presentation of COVID-19 in children.ObjectiveWe performed this study to assess the association between KD and COVID-19.Methods and MaterialsWe evaluated KD hospitalized children during February to September 2020 for COVID-19 (group one) and compared their demographic, clinical, laboratory, and echocardiographic findings with KD patients from the same period time in 2019 (group two). We also compared the same data in COVID-19 positive and COVID-19 negative KD patients in 2020 pandemic period.ResultsSixty eight percent of group one KD patients were positive for COVID-19 during the pandemic period. KD Age of onset in the group one was lower than group two (4.38 years VS 5.5 years, P-value= 0.044). There was no difference in the demographic, clinical, laboratory, and echocardiographic features of the patients during and before the COVID-19 pandemic (p-value > 0.05). Moreover, Comparing COVID-19 positive and negative patients, the incidence of rash was higher within COVID-19 positive cases (p<0.05), and coronary artery abnormalities were more prevalent in COVID-19 negative cases (p < 0.05).ConclusionAdmission rate of KD does not have significant difference during the COVID-19 pandemic but 68% of KD admitted patient were COVID-19 positive. Age of onset for KD during the COVID-19 pandemic was lower and skin manifestation was higher than the same period time in last year.

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Section: Discussionsupporting

confidence: 89%

Effect of COVID-19 on Kawasaki Disease: Decrease Age of Onset and Increase Skin Manifestation

Esmaeilzadeh

Mortazavi

Salehi

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…The most common clinical presentation of KD was rash (seen in 62% of patients), oral mucosa and lip involvement (58%), and extremity changes (58%). Our ndings were similar to the ndings of Cheraghali F et al [17] introducing skin rash (68.6%) and changes of the lip and oropharyngeal mucosa (60.8%) as the most common manifestations of KD, but were slightly different from Pilania R.K. et al which showed oral cavity and lips' changes as the most common manifestation (> 95%) of KD, and rash as the second (> 90%). Furthermore, our results showed that neck lymphadenopathy was the least common clinical nding which is compatible with Pilania R.K. et al) [18].…”

Section: Discussionsupporting

confidence: 89%

Association of Kawasaki Disease and COVID-19 in children

Esmaeilzadeh

Mortazavi

Salehi

et al. 2021

Preprint

View full text Add to dashboard Cite

Kawasaki Disease (KD) is most common childhood vasculitis and cause of acquired heart disease for no apparent reason. There is some evidence indicating infectious agents as possible triggers for KD. During the COVID-19 pandemic, vasculitis has been a presentation of COVID-19 in children.ObjectiveWe performed this study to assess the association between KD and COVID-19.Methods and MaterialsWe evaluated KD hospitalized children during February to September 2020 for COVID-19 (group one) and compared their demographic, clinical, laboratory, and echocardiographic findings with KD patients from the same period of time in 2019 (group two). We also compared the same data in COVID-19 positive and COVID-19 negative KD patients in 2020 pandemic period.Results68% of KD patients in group one were positive for COVID-19 during the pandemic period. KD Age of onset in the group one was lower than group two (4.38 years VS 5.5 years, P-value= 0.044). There was no difference in the demographic, clinical, laboratory, and echocardiographic features of the patients during and before the COVID-19 pandemic (p-value > 0.05). Moreover, Comparing COVID-19 positive and negative patients, the incidence of rash was higher within COVID-19 positive cases (p<0.05), and coronary artery abnormalities were more prevalent in COVID-19 negative cases (p < 0.05).ConclusionAdmission rate of KD does not have significant difference during the COVID-19 pandemic but 68% of KD admitted patient were COVID-19 positive. Age of onset for KD during the COVID-19 pandemic was lower than the same period of time in last year.

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“…A total of 40% of our patients experienced conjunctivitis. Rates mentioned in the literature are higher (Cheraghali et al [ 2 ] 51%; Mahmoudzadeh et al [ 18 ] 83%). We believe providing education to patients regarding the prevention of conjunctivitis was a beneficial factor in our study.…”

Section: Discussionmentioning

confidence: 99%

“…However, the leading theory is that an unknown infectious agent activates the immune system in a genetically vulnerable child. Kawasaki disease is more prevalent among males and most studies have mentioned a gradual increase in the number of cases from March to June [ 1 , 2 ].…”

Section: Introductionmentioning

confidence: 99%

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Kawasaki disease in children: a retrospective cross-sectional study

Hosseininasab,

Pashang,

Rezaei Zadeh Rukerd

et al. 2023

Reumatologia

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IntroductionKawasaki disease (KD) is a systemic vasculitis, seen mostly in children. Epidemiology of KD is dependent on geographical location and seasonality. Although many years have passed since the first report of KD, multiple related factors are still unknown.Material and methodsWe investigated the clinical, paraclinical, and therapeutic aspects of KD in Kerman, Iran by performing a retrospective, descriptive, cross-sectional study on all children hospitalized due to KD between 2007 and 2020.ResultsA total of 340 patients with mean ±SD age of 29.83 ±22.55 months participated in the study. Most of our patients were two to five years old. The male : female ratio was ~ 1.4 : 1. A few of our patients had a family history of KD or vasculitis (0.3%, 1.7%). Typical KD was more common by a large margin (316 patients with typical KD). More than half of our patients had a duration of hospitalization of under ten days. All of our patients were febrile. Hand/foot and lip/mouth changes were the second and third most common clinical findings in more than 60% of our patients. Other manifestations were conjunctivitis in 40%, skin rashes in 34.8%, gastrointestinal manifestations in 33.9%, and lymphadenopathy in 25.3%. Echocardiography revealed abnormalities in 78.6% of the participants; coronary artery aneurysm (CAA) was the most frequent (22.5%) and follow-up echocardiography revealed that all of them regressed within 6 months after treatment. The two laboratory tests with the highest ratio of abnormality were erythrocyte sedimentation rate (95%) and hemoglobin (83.3%). C-reactive protein and liver function tests were also abnormal in most patients. All of our patients received intravenous immunoglobulin and acetylsalicylic acid.ConclusionsKawasaki disease must be considered in every febrile child, especially those with risk factors, because timely diagnosis and treatment are essential to prevent complications. Health policies should focus on appropriate diagnosis and treatment to prevent the occurrence of sequelae.

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Prevalence of Kawasaki Disease in Children Admitted to Taleghani Medical Center in Gorgan, Iran

Cited by 4 publications

References 11 publications

Effect of COVID-19 on Kawasaki Disease: Decrease Age of Onset and Increase Skin Manifestation

Effect of COVID-19 on Kawasaki Disease: Decrease Age of Onset and Increase Skin Manifestation

Association of Kawasaki Disease and COVID-19 in children

Kawasaki disease in children: a retrospective cross-sectional study

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