Prevalence of Lactose Intolerance in Patients with Hashimoto Thyroiditis and Impact on LT4 Replacement Dose

Marabotto, Elisa; Ferone, Diego; Sheijani, Afscin Djahandideh; Vera, Lara; Ziola, Sebastiano; Savarino, Edoardo; Bodini, Giorgia; Furnari, Manuele; Zentilin, Patrizia; Savarino, Vincenzo; Giusti, Massimo; Rojas, Fabiola Andrea Navarro; Bagnasco, Marcello; Albertelli, Manuela; Giannini, Edoardo G.

doi:10.3390/nu14153017

Cited by 4 publications

(2 citation statements)

References 31 publications

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“…The need for a higher dose of levothyroxine in lactose intolerant patients was reported by other authors [ 41 ]. However, Marabotto et al [ 42 ] did not observe any differences in cumulative LT4 dose requirements in Hashimoto’s disease patients with or without lactose intolerance. To the best of our knowledge, studies to date have shown no benefit from lactose restriction in people with Hashimoto’s disease who have not been treated with levothyroxine.…”

Section: Discussionmentioning

confidence: 97%

The Influence of Nutritional Intervention in the Treatment of Hashimoto’s Thyroiditis—A Systematic Review

Osowiecka

Myszkowska-Ryciak

2023

Nutrients

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Diet can be a complementary treatment for Hashimoto’s disease by affecting thyroid function and anti-inflammatory properties. It is still unclear which dietary strategy would be the most beneficial. The aim of this systematic review is to examine all the data currently available in the literature on the effects of nutritional intervention on biochemical parameters (anti-thyroid antibody and thyroid hormones levels) and characteristic symptoms in the course of Hashimoto’s thyroiditis. This systematic review was prepared based on PRISMA guidelines. Articles in PubMed and Scopus databases published up to November 2022 were searched. As a result of the selection, out of 1350 publications, 9 were included for further analysis. The nutritional interventions included the following: elimination of gluten (3 articles) or lactose (1 article), energy restriction with or without excluding selected foods (n = 2), consumption of Nigella sativa (n = 2), or dietary iodine restriction (n = 1). The intervention duration ranged from 21 days to 12 months and included individuals with various thyroid function. Of the nine studies, three studies were female only. An improvement was observed during an energy deficit and after the elimination of selected ingredients (e.g., gluten, lactose, or goitrogens), as well as after the intervention of Nigella sativa. These interventions improved antibody levels against peroxidase (anti-TPO), (thyrotropin) TSH, and free thyroxine (fT4). No improvement was seen on the iodine-restricted diet. Varied outcomes of analyzed dietary interventions may be due to the heterogeneous thyroid condition, high variability between patients, and differences in habitual intake of critical nutrients (e.g., iodine, selenium, and iron) in different populations. Therefore, there is a great need for further experimental studies to determine whether any nutritional interventions are beneficial in Hashimoto’s disease.

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Section: Discussionmentioning

confidence: 97%

The Influence of Nutritional Intervention in the Treatment of Hashimoto’s Thyroiditis—A Systematic Review

Osowiecka

Myszkowska-Ryciak

2023

Nutrients

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“…Although some patients with IBS often benefit from a lactose-free diet, the evidence is still inconsistent and shows conflicting results [ 130 , 149 ]. Nevertheless, the presence of lactose in medications seems not to influence their effectiveness or induce gastrointestinal symptoms compared with lactose-free formulations, meaning that no drugs should be avoided in the design of a lactose-free diet [ 150 ].…”

Section: Which Dietary Patterns Are Useful In Food Intolerance In Ibs...mentioning

confidence: 99%

Food Intolerances, Food Allergies and IBS: Lights and Shadows

Pasta,

Formisano,

Calabrese

et al. 2024

Nutrients

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This narrative review delves into the intricate relationship between irritable bowel syndrome (IBS) and food intolerances. IBS, a chronic functional gastrointestinal disorder, is characterized by symptoms like abdominal pain and altered bowel habits. The prevalence of IBS has increased globally, especially among young adults. Food and dietary habits play a crucial role in IBS management. About 85–90% of IBS patients report symptom exacerbation linked to specific food consumption, highlighting the strong connection between food intolerances and IBS. Food intolerances often exhibit a dose-dependent pattern, posing a challenge in identifying trigger foods. This issue is further complicated by the complex nature of gastrointestinal physiology and varying food compositions. This review discusses various dietary patterns and their impact on IBS, including the low-FODMAP diet, gluten-free diet, and Mediterranean diet. It highlights the importance of a personalized approach in dietary management, considering individual symptom variability and dietary history. In conclusion, this review emphasizes the need for accurate diagnosis and holistic management of IBS, considering the complex interplay between dietary factors and gastrointestinal pathophysiology. It underlines the importance of patient education and adherence to treatment plans, acknowledging the challenges posed by the variability in dietary triggers and the psychological impact of dietary restrictions.

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The Role of Herbal Therapy in the Treatment of Graves’ Disease and Hashimoto Thyroiditis

Kafadar,

Demir

2024

Herbal Medicine for Autoimmune Diseases

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Currently, Hashimoto's thyroiditis (HT) and Graves' disease (GD) are the foremost conditions that people think of when discussing autoimmune thyroid disorders. While radioactive iodine (RAI) treatment, anti-thyroid drugs, and surgical resection are currently at the forefront for GD; thyroid replacement therapy is used for HT. Many studies are being performed to develop new treatment methods for Graves and Hashimoto thyroiditis patients who do not respond to traditional treatments. While herbal treatments are being tried for GD, studies are being carried out on changing nutritional habits or additional food supplements for HT. While there are currently many studies on traditional Chinese medicine in the literature for GD, nutrients for HT are considered complementary treatments using their anti-inflammatory and antioxidant properties. In patients with HT, the need for levothyroxine increases, especially due to possible interactions of gliadin with thyroid antigens, the presence of lactose components in levothyroxine preparations, and damage to the intestinal villi in those with lactose intolerance. Therefore, the course of the disease may be better in HT patients with additional dietary recommendations.

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Prevalence of Lactose Intolerance in Patients with Hashimoto Thyroiditis and Impact on LT4 Replacement Dose

Cited by 4 publications

References 31 publications

The Influence of Nutritional Intervention in the Treatment of Hashimoto’s Thyroiditis—A Systematic Review

The Influence of Nutritional Intervention in the Treatment of Hashimoto’s Thyroiditis—A Systematic Review

Food Intolerances, Food Allergies and IBS: Lights and Shadows

The Role of Herbal Therapy in the Treatment of Graves’ Disease and Hashimoto Thyroiditis

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