Prevalence of latent tuberculosis infection among coal workers’ pneumoconiosis patients in China: a cross-sectional study

Yan, Jin; Wang, Huanqiang; Zhang, Jianfang; Ding, Chunguang; Wen, Ke; Fan, Jie; Li, Tao

doi:10.1186/s12889-018-5373-1

Cited by 13 publications

(12 citation statements)

References 27 publications

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“…Coal workers with chronic exposure to coal dust often present a variety of respiratory illnesses. The main disease is pneumoconiosis and the most common complication is pulmonary tuberculosis [ 2 ]. Therefore, in previous reports [ 3 ], chest radiographs and CT images often showed multiple pulmonary nodules, interstitial fibrosis and emphysema.…”

Section: Resultsmentioning

confidence: 99%

An unusual tracheal foreign body in a middle-aged male with a 15-year history of coal use: a case report

et al. 2021

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Background Long-term exposure to coal dust causes respiratory disease. In chest computer tomography (CT), pulmonary nodules, pulmonary interstitial fibrosis and emphysema manifest themselves. However, tracheal foreign bodies caused by coal dust are rarely reported. In this study, we report a special case of a tracheal coal foreign body, in which the patient has neither a history of coal work nor foreign body inhalation. Case presentation A 49-year-old man was diagnosed with chronic obstructive pulmonary disease (COPD) due to chronic cough and exertional dyspnoea. His symptoms gradually worsened despite treatment for COPD. Chest radiograph and CT images showed an irregular high-density nodule inserting fromthe trachea into the right thyroid at approximately the level of the 7th cervical vertebra. Fiberoptic bronchoscopy revealed that the tracheal lumen was mostly blocked. After the surgery, the energy spectrum CT quantitative analysis showed that the foreign body was likely that of a bituminous coal specimen. Conclusions For cases in which a foreign body in the airway is highly suspected, early fiberoptic bronchoscopy and radiographic examinations should be performed as soon as possible to avoid misdiagnosis and ensure timely treatment.

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Section: Resultsmentioning

confidence: 99%

An unusual tracheal foreign body in a middle-aged male with a 15-year history of coal use: a case report

et al. 2021

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“…( 13 ) Another study evaluated 244 patients with coal workers' pneumoconiosis and found a positive IGRA in 162 (66.4%) of them. ( 14 ) There are no studies on LTBI in patients with other types of ILD. It is not possible to ascertain whether the prevalence found in our study reflects the true prevalence in this population.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of latent tuberculosis infection among patients with interstitial lung disease requiring immunosuppression

Dias

Storrer

2022

J Bras Pneumol.

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Objective: To characterize the prevalence of latent tuberculosis infection (LTBI) in patients with interstitial lung diseases (ILDs) requiring immunosuppression. Only 5 to 10% of individuals infected with Mycobacterium tuberculosis develop tuberculosis, and certain groups of patients have an increased risk of illness, such as the immunocompromised. Patients with ILDs are frequently treated with immunosuppressants and, therefore, might have a higher risk of developing the disease. Methods: Prospective study conducted at the ILD reference center of the Federal University of Paraná from January 2019 to December 2020. The screening of LTBI was performed with the use of the tuberculin skin test (TST). Results: The sample consisted of 88 patients, of whom 64.8% were women, with a mean age of 61.4 years. The most frequent diagnoses were autoimmune rheumatic disease ILD (38.6%) and hypersensitivity pneumonitis (35.2%). The most common immunosuppressant in use at the time of the TST was prednisone, either in combination with mycophenolate (19.3%) or alone (17.1%). The majority of participants had fibrotic lung disease, characterized by a reticular interstitial pattern on chest computed tomography (79.5%) and moderate to severe functional impairment (mean FVC 69.2%). A prevalence of LTBI of 9.1% (CI 95%, 2.1%-15.1%) was found, with a TST median of 13. Conclusion: Patients with ILD who are treated with immunosuppressants are not commonly screened for LTBI, despite being under a greater risk of progression to active disease. This study suggests the need for a more cautious approach to these patients.

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“…Previous studies have found that the latent infection rate of PTB in patients with pneumoconiosis is 65%, which was significantly higher than that in the general population (20%). [ 34 ] It is recommended that clinicians evaluate for LTBI and the immune status of the patient before using hormone drugs for pneumoconiosis.…”

Section: Discussionmentioning

confidence: 99%

Epidemiological characteristics of pulmonary tuberculosis in patients with pneumoconiosis based on its social determinants and risk factors in China: a cross-sectional study from 27 provinces

Wang

Dai

et al. 2022

Chinese Medical Journal

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Background:Patients with pneumoconiosis have an elevated risk of contracting pulmonary tuberculosis (PTB) and need particular attention. However, extensive population-based studies on the prevalence of PTB in patients with pneumoconiosis have not been reported in China since 1992. This study aimed to investigate the epidemiological characteristics of PTB in patients with pneumoconiosis based on its social determinants and risk factors in China.Methods:Based on the Commission on Social Determinants of Health (CSDH) framework, data were obtained from a questionnaire survey of patients with pneumoconiosis from China's 27 provinces (autonomous regions, municipalities) from December 2017 to June 2021. By chi-square and multivariate logistic regression analyses, the epidemiological characteristics of PTB in the patients were identified based on its prevalence and odds ratio (OR) and associated social determinants and risk factors. The population attributable fractions (PAFs) of significant risk factors were also calculated.Results:The prevalence of PTB in patients with pneumoconiosis (n = 10,137) was 7.5% (95% confidence interval [CI]: 7.0–8.0%). Multivariate logistic regression analysis showed that risk factors included in-hospital exposure to patients with PTB (OR = 3.30, 95% CI: 2.77–3.93), clinically diagnosed cases (OR = 3.25, 95% CI: 2.42–4.34), and northeastern regions (OR = 2.41, 95% CI: 1.76–3.31). In addition, lack of work-related injury insurance (WRII), being born in a rural area, being unemployed, living in western regions, household exposure to patients with PTB, smoking, being underweight, complications of pulmonary bullae or pneumothorax, hospitalization history, and former drinkers among the rural patients were also statistically significant risk factors. Being born in a rural area, lack of WRII and in-hospital exposure to patients with PTB had higher PAFs, which were 13.2% (95% CI: 7.9–18.5%), 12.5% (95% CI: 8.3–16.7%), and 11.6% (95% CI: 8.8–14.3%), respectively.Conclusion:The prevalence of PTB in pneumoconiosis remains high in China; it is basically in line with the CSDH models and has its characteristics.

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Prevalence of latent tuberculosis infection among coal workers’ pneumoconiosis patients in China: a cross-sectional study

Cited by 13 publications

References 27 publications

An unusual tracheal foreign body in a middle-aged male with a 15-year history of coal use: a case report

An unusual tracheal foreign body in a middle-aged male with a 15-year history of coal use: a case report

Prevalence of latent tuberculosis infection among patients with interstitial lung disease requiring immunosuppression

Epidemiological characteristics of pulmonary tuberculosis in patients with pneumoconiosis based on its social determinants and risk factors in China: a cross-sectional study from 27 provinces

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