Prevalence of Leukemia and Associated Factors among Patients with Abnormal Hematological Parameters in Jimma Medical Center, Southwest Ethiopia: A Cross-Sectional Study

Kassahun, Woldeteklehaymanot; Tesfaye, Girum; Bimerew, Lealem Gedefaw; Fufa, Diriba; Adissu, Wondimagegn; Yemane, Tilahun

doi:10.1155/2020/2014152

Cited by 21 publications

(18 citation statements)

References 24 publications

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“…In the current study, with regard to gender, most of the cases were male (66.7%) while the percentage of females was 33.3% (male to female ratio = 2:1). This finding differs from that reported in Africa where the ratio of males to females is roughly equal, although females dominate slightly (1: 1.06) [23], but similar to that reported from the United States where the American Cancer Society estimates for leukemia in 2021, about 5,690 new cases, 3,000 in males and 2,690 in females [24]. The current results of different leukemia prevalence rates among gender are in line with the facts that the prevalence of leukemia must be varies according to gender due to the biological factors as hormones and chromosomes [11,15,25,26].…”

Section: Discussioncontrasting

confidence: 99%

Therapeutic and evolutionary characteristics of Diabetic ketosis decompensations after a decade at the University Hospital of Cotonou, Benin

Jules¹

2021

JED

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Aim: To evaluate the therapeutic and evolutionary aspects of diabetic ketosis decompensation, a decade after its previous report in our center. Materials and Method: This was a 3-year retrospective study, including all patients admitted from June 1, 2016 to May 31, 2019 for DKA at the Endocrinology and Metabolic Diseases Department of the National and University Hospital Hubert Koutoukou Maga (CNHU-HKM). Ketosis was defined by the presence of at least 2 acetone crosses on the urine strip. Results: A total of 196 patients were included. The mean age was 43.73 years ± 16.2 years with a sex ratio of 0.96. The prevalence of DKA was 28.99%. The main precipitating factors of DKA were infections (67.86%) and non-compliance to the treatment (29.59%). The most common infections were urogenital (23.30%), respiratory (18.04%) and malaria (32.33%). The mortality was 2.55%. Male subjects (84.36%) had blood glucose levels above 3g/L with a higher mean dose of insulin used (84.71 IU versus 54.29 IU for women p=0.008). Duration of recovery (p=0.008) and length of hospitalization (p=0.006) were statistically longer for men. Conclusion: The prevalence of ketosis decompensations remains high. The main decompensation factors found were infections and non-compliance to treatment. Improving patient care over the past decade had produced a positive impact on mortality, recovery time and length of hospitalization.

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Section: Discussioncontrasting

confidence: 99%

Therapeutic and evolutionary characteristics of Diabetic ketosis decompensations after a decade at the University Hospital of Cotonou, Benin

Jules¹

2021

JED

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“…(1: 1.06) [22], but similar to that reported from the United States where the American Cancer Society estimates for leukemia in 2021, about 5,690 new cases, 3,000 in males and 2,690 in females [23].…”

Section: Discussionsupporting

confidence: 73%

Prevalence of Different Types of Leukemia and Associated Factors among Children with Leukemia in Children’s Cancer Units at Al-Kuwait Hospital, Sana’a City: A Cross-Sectional Study

Shamahy¹

2021

GJPNC

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Background and aims: Leukemia is a heterogeneous group of haematological disorders that is made up of several diverse and biologically distinct subgroups. Leukemia is the eleventh and tenth most common cause of cancer morbidity and mortality worldwide, respectively. There are insufficient data on the prevalence and associated factors of leukemia in Yemen, particularly in the study area. This cross-sectional study aims to determine the prevalence of different types of leukemia and associated factors among children with leukemia in the pediatric cancer units of Al-Kuwait Hospital, Sana'a City. Patients and method: A cross-sectional study was conducted on children with leukemia who were treated selectively in the pediatric leukemia units of Kuwait University Hospital in Sana'a. Group diagnostics and histopathological diagnoses were formed in line with the French, American and British classifications of leukemia in children in the pediatric leukemia units, over a period of 5 years from January 1, 2014 to December 31, 2018. Factors associated with become infected with leukemia that were studied included ages, sex, and outcomes. The association of death and recovery with different age groups and leukemia types was also studied through rates and calculation of OR, CI, X2 and p values through probability tables (2x 2 tables). Results: 244 leukemia patients were diagnosed, treated and followed up; there was association of leukemia with younger age group; 50% were in the age group 1-5 years and with mean ± SD age= 6.44 ± 3.7 years. There was significant association with male (66.7%). There was association between high mortality and the 6-10 year age group [(8/78; 10.2%), with OR = 2.6, p = 0.060], and with the AML [(4/38; 10.5%), OR = 2.1)]. Considering, the cure rates association with ages, roughly there were similar cure rates occurred the different age groups. Also, there was high cure rate occurred in the JCM (2/3; 66%), with OR = 2.9. and with the CML (7/11; 63.6%; OR = 2.60. Conclusion: In the current study there was an association between leukemia and younger age group, with males. There was an association between high mortality and the 6-10 year age group, with AML. Also, there was no association between ages and cure rate, but a high cure rate occurred with JCM and CML. More comprehensive investigations of relevant factors and predictors are needed with more modern diagnostic methods and investigate correlation factors with the treatment protocols used.

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“…This result was similar to the findings reported in Morocco (10.9%), and Ethiopia (9.3%). 26,28 The current prevalence was low compared to the result reported in Eritrea (25.1%), in India (58%), and Togo (31%). [29][30][31] The possible reasons for this variation might be the variations in sample size, study population, geographical location, and socio-demographic pattern.…”

Section: Discussionmentioning

confidence: 77%

Patterns of Bone Marrow Confirmed Malignant and Non-Malignant Hematological Disorders in Patients with Abnormal Hematological Parameters in Northeast Ethiopia

Ebrahim¹,

Fiseha²,

Debash³

et al. 2022

JBM

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Background Hematological disorders are heterogeneous conditions ranging from malignant to non-malignant disorders. Hematological malignancies comprise a collection of heterogeneous conditions originating from cells of the bone marrow and the lymphatic system. Therefore, this study aimed to determine the pattern of bone marrow confirmed malignant and non-malignant hematological disorders in patients with abnormal hematological parameters. Methods Institutional-based cross-sectional study was conducted in Dessie town from April 2020 to June 2021. A total of 228 study participants who had abnormal hematological parameters and referred for bone marrow examination were included consecutively. About 1.5 mL of bone marrow sample and 3 mL of venous blood sample were collected for bone marrow examination, complete blood count analysis and peripheral blood morphology examination. Wright stain, Sudan black B, and Prussian blue stains were used for staining the bone marrow and peripheral blood smears. The result was expressed in mean and standard deviation and presented in texts and tables. Ratio, frequency, and percentage were used to express the magnitude of malignant and non-malignant hematological disorders. Results The overall prevalence of hematological malignancies among the study participants was 11.4% with 8.8% in male patients. The prevalence of hematological malignancies were 3.5% CML, 2.6% AML, 1.8% CLL and MM, 0.9% ALL and undifferentiated acute leukemia. On the other hand, 57.0% of the study participants had non-malignant hematological disorders. Regarding non-malignant hematological cases, 24.6% were erythroid hyperplasia, 10.5% aplastic anemia, 8.8% concomitant IDA and MBA, 7.0% MBA, 3.5% leukemoid reaction, 1.8% IDA, and 0.9% visceral leishmaniasis. In patients with HM, 66.7% of AML, 100% of CML and CLL, and 75% of MM patients had increased total WBC count, whereas 66.7% of AML, 62.5% of CML, 75% of CLL, and 50% of MM patients had decreased hemoglobin level. On the other hand, 66.7% of AML, and 50% of CML, ALL, and CLL patients had decreased platelet count. Conclusion In this study, 11.4% of the patients had hematological malignant cases, whereas 57% of the patients had non-malignant hematological cases. Therefore, in patients with hematological abnormalities and where conclusive diagnosis could not be made through clinical and other laboratory investigations, bone marrow examination should be done for definitive diagnosis, management and prognosis.

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Prevalence of Leukemia and Associated Factors among Patients with Abnormal Hematological Parameters in Jimma Medical Center, Southwest Ethiopia: A Cross-Sectional Study

Cited by 21 publications

References 24 publications

Therapeutic and evolutionary characteristics of Diabetic ketosis decompensations after a decade at the University Hospital of Cotonou, Benin

Therapeutic and evolutionary characteristics of Diabetic ketosis decompensations after a decade at the University Hospital of Cotonou, Benin

Prevalence of Different Types of Leukemia and Associated Factors among Children with Leukemia in Children’s Cancer Units at Al-Kuwait Hospital, Sana’a City: A Cross-Sectional Study

Patterns of Bone Marrow Confirmed Malignant and Non-Malignant Hematological Disorders in Patients with Abnormal Hematological Parameters in Northeast Ethiopia

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