Background: Colorectal cancer (CRC) as the most frequent malignant disease of the gastrointestinal tract, shows around 9.5% of all incident cancer internationally. However, different countries report dissimilar rates in incidence, but the rates change with time. Objectives: The aim of this study was to provide information associated with the CRC rate of incidence in Isfahan Province, Iran. Methods: This investigation was accompanied by Isfahan Kidney Transplantation Research Center. Data were collected from the Isfahan Cancer Registry. Period prevalence (PP) and incidence rate (Irs) were considered and reported per 100,000 persons. Results: In all, there were 2623 patients with CRC comprised of 2112 alive and 511 deceased reported individuals. For the total population, the PP was calculated as 52.6 and Irs significantly increased (P < 0.01) from 10.3 to 15.1 per 100,000 people. The mean (SD, range) age of the patients was 62.0 (14.4, 3-98) years. The total PP was corresponded to a value of 22.6 for females and 30.1 for males. Conclusions: There was a 47% increase in the rate of incidence over the investigated period. The PP was 6.8% higher in males than in females. In relation to the age, cancers occurred in 82% after 50 years old of life. Therefore, for allocation of health-care resources and attention toward strategic-based decisions, further studies in this direction seem to be advantageous.