Prevalence of Liver Disease in Patients with Streptococcus bovis Bacteraemia

Gonzlez-Quintela, A.; Martínez-Rey, Carmen; Castroagudı́n, J.F.; Rajo-Iglesias, M.C.; Domínguez-Santalla, Maria-Jesus

doi:10.1053/jinf.2001.0799

Cited by 64 publications

(48 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As noted before, endocarditis caused by S agalactiae followed a complicated course characterized by large vegetations, rapid destruction of cardiac valves and heart failure [15,16]. In addition, chronic liver disease has been recognized as a predisposing factor for S bovis bacteremia which may explain the increased frequency of endocarditis caused by these microorganisms in our series [17].…”

Section: Introductionsupporting

confidence: 60%

Infectious endocarditis in patients with cirrhosis of the liver: a model of infection in the frail patient

Guerrero

González-López

Górgolas

2010

Eur J Clin Microbiol Infect Dis

View full text Add to dashboard Cite

Abstract:To know whether cirrhosis is a predisposing cause of IE and to determine the microbiology, prognosis and the role of cardiac surgery on mortality. Review of cases of infectious endocarditis in a university-affiliated hospital during 10 years. Thirty-one(9.8%) patients among 316 cases of infectious endocarditis had hepatic cirrhosis. Valve disorders were present in 62.2% of cirrhotic patients and infection occurred on aortic(48%) and mitral valves(45%).Endocarditis was hospital-acquired in 14(45%) and 11(17.7%) of cirrhotic and controls respectively(OR 3.82;95%CI:1.46-9.99;p 0.005).Staphylococcus aureus was the most common causative microorganism but βeta-hemolytic streptococci were most frequently isolated in cirrhotic patients (OR 8.75; 95% CI: 1.7-45.2;p 0.001).Renal failure was more frequent in patients with cirrhosis (OR 8.23; p 0.001).Cirrhotic patients had a higher mortality(51% vs 17.7%; OR 4.95;95%CI:1.89-12.91;p 0.001) associated with the severity of liver disease. Valve replacement was performed less frequently in cirrhotic patients(56.2% vs 92%) and the operative mortality was extremely high in patients with stages B and C. Hepatic cirrhosis is a frequent comorbid condition in patients with endocarditis. Due to the presence severe hepatic dysfunction, cardiac surgery is not undertaken even when indicated and mortality is high in stages B and C. Endocarditis is a serious hazard for hospitalized cirrhotic patients.Response to Reviewers: Dear Dr. Van Belkum:Thank you very much for the opportunity of revising the above mentioned manuscript. In doing the revision, I have taken into account all the suggestions of the reviewer.Firstly, let me tell you why we chose to perform a case-control study instead of a case-cohort comparison. A case-control study is a simple and very useful investigative tool to identify factors that may contribute to the understanding of many medical conditions. In this case, we compared patients with cirrhosis of the liver and endocarditis with subjects with endocarditis but without such underlying disease. In short, we looked back to see if there were characteristics of these patients that differ from those who did not have cirrhosis. The main reasons of our choice were: 1. Simplicity. 2. Accuracy. Because patients were seen over a relatively long period -10 years-we tried to bring nearer cases and controls to avoid biases associated with changes in diagnostic techniques (use of TEE, blood cultures), antibiotic usage or surgical team over the time. For this reason we selected two controls for each case: the previous and the consecutive to the index case.Reviewer:1. Our patients with cirrhosis of the liver were not on any type of chronic antimicrobial therapy with fluoroquinolones or other agents such as those that are administered for the prevention of primary bacterial peritonitis. We have included a short comment on this in the last paragraph of page 7. This is an interesting comment because such intervention may eventually favour enterococcal infections. Our cases, enter...

show abstract

Section: Introductionsupporting

confidence: 60%

Infectious endocarditis in patients with cirrhosis of the liver: a model of infection in the frail patient

Guerrero

González-López

Górgolas

2010

Eur J Clin Microbiol Infect Dis

View full text Add to dashboard Cite

show abstract

“…However, S. gallolyticus subsp. pasteurianus can cause septicemia and is often associated with, e.g., chronic liver disease or cirrhosis, especially in immunocompromised patients (33,34). Besides human infections, to date there have been only two reported cases of septicemia due to S. gallolyticus subsp.…”

Section: Discussionmentioning

confidence: 99%

Development and Application of a Multilocus Sequence Typing Scheme for Streptococcus gallolyticus subsp. gallolyticus

et al. 2014

View full text Add to dashboard Cite

Streptococcus gallolyticus subsp. gallolyticus (formerly known as S. bovis biotype I) is a commensal of the gastrointestinal tract in animals and in up to 15% of healthy humans. Furthermore, it is a facultative pathogen that can cause infectious endocarditis, mastitis, and septicemia. The number of infections is increasing, but the transmission routes and zoonotic potential remain unknown. To assess the zoonotic potential and characterize the epidemiological structure of S. gallolyticus subsp. gallolyticus, we established a multilocus sequence typing (MLST) scheme. We amplified and sequenced internal fragments of seven housekeeping genes. The resulting sequences were analyzed with BioNumerics software 6.6 by using the unweighted-pair group method using average linkages algorithm. A total of 101 S. gallolyticus subsp. gallolyticus strains isolated from animals, humans, and environmental samples were analyzed and divided into 50 sequence types. Our first results highlight the importance of this MLST scheme for investigating the epidemiology, transmission patterns, and infection chains of S. gallolyticus subsp. gallolyticus.

show abstract

“…Studies have also linked spontaneous bacterial peritonitis caused by S. bovis, especially biotype II, with chronic liver disease (7)(8)(9)(10). One limitation of our study is the lack of biotyping data for the various S. bovis strains.…”

Section: Discussionmentioning

confidence: 99%

“…S. bovis I classically causes infective endocarditis and primary bacteremia, and its link with colorectal carcinoma is well established (4)(5)(6)(7). S. bovis II is associated with chronic liver disease, and cases of spontaneous bacterial peritonitis have also been reported (7)(8)(9)(10). However, data about PD peritonitis caused by S. bovis are lacking, and the association of this organism with colorectal malignancy and other medical diseases remains undefined.…”

mentioning

confidence: 99%

Streptococcus Bovis Peritonitis Complicating Peritoneal Dialysis—A Review of 10 Years’ Experience

Yap

Yip

et al. 2012

Perit Dial Int

View full text Add to dashboard Cite

♦ Objective: An association of Streptococcus bovis bacteremia with carcinoma of colon has been reported, but data regarding peritoneal dialysis (PD) peritonitis caused by S. bovis is scarce. In this study, we examined the clinical characteristics, associations, and outcomes of this disease entity. ♦ Methods: The case records of patients with S. bovis PD peritonitis presenting to 2 renal centers between January 2000 and September 2010 were reviewed. Clinical features and outcomes were identified and analyzed. ♦ Results: Of cultures from 23 episodes of S. bovis peritonitis in 20 patients (1.28% of all peritonitis episodes at our center), 19 (82.6%) showed S. bovis alone, and 4 (17.4%) showed mixed growth. In 7 episodes, the S. bovis was moderately resistant to penicillin G. Rates of resistance to clindamycin and erythromycin were 43.5% and 47.8% respectively. In 18 episodes (78.3%), a primary response was achieved with a first-generation cephalosporin and an aminoglycoside. In 4 episodes, a secondary response was achieved after a switch from cephalosporin to vancomycin, and in 1 episode with mixed growth, the Tenckhoff catheter had to be removed. Repeat peritonitis occurred in 3 patients at a mean of 50.0 months (range: 24.2 -83.1 months). Of the 20 patients of S. bovis peritonitis, 10 (50%) underwent either a barium enema or a colonoscopy. One patient had history of colonic carcinoma 2 years before the peritonitis, and a subsequent work-up revealed no recurrence. Three patients had diverticulosis, and one had a concomitant sigmoid polyp. Findings in the other 6 patients were normal. No colorectal malignancy had developed in the remaining 10 patients after a mean follow-up of 76.6 months (range: 0.8 -125.1 months). ♦ Conclusions: Outcomes in S. bovis PD peritonitis were favorable, and an association with colorectal cancer was not found in our patients. Routine colonoscopy in these patients remains controversial and should be individualized.

show abstract

Prevalence of Liver Disease in Patients with Streptococcus bovis Bacteraemia

Cited by 64 publications

References 28 publications

Infectious endocarditis in patients with cirrhosis of the liver: a model of infection in the frail patient

Infectious endocarditis in patients with cirrhosis of the liver: a model of infection in the frail patient

Development and Application of a Multilocus Sequence Typing Scheme for Streptococcus gallolyticus subsp. gallolyticus

Streptococcus Bovis Peritonitis Complicating Peritoneal Dialysis—A Review of 10 Years’ Experience

Contact Info

Product

Resources

About