Prevalence of Low Bone Mass in Patients with Hemophilia and Its Related Ractors in Southern Iran

Bordbar, Mohammadreza; Olyaeinezhad, Sara; Saki, Forough; Haghpanah, Sezaneh

doi:10.5812/compreped.97291

Cited by 3 publications

(1 citation statement)

References 32 publications

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“…(2019) and Bordbar et al (2020) discovered that patients with low BMD had significantly higher incidences of HCV and HBV.…”

Section: Discussionmentioning

confidence: 99%

Association Between Low Bone Mineral Density in Hemophilia Patients and Musculoskeletal Function Impairments

2024

J Angiotherapy

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Background: Hemophilia A (HA) and B (HB) are inherited bleeding disorders due to the partial or total deficiency of coagulation factor (F) VIII or FIX, respectively. It is associated with low bone mineral density (BMD). Method: The current study was conducted on sixty-eight Iraqi patients with hemophilia to assess BMD using a DEXA scan enrolled from the National Center of Hematology / Mustansiriyah University from July 2020 to September 2021. Various medical history characteristics were recorded as (age, type of hemophilia, severity, number and site of bleeding, smoking, and alcohol intake) as well as Functional Independence Score in Haemophilia (FISH) was used to assess musculoskeletal functions and Hepatitis C virus (HCV)/Human immunodeficiency virus (HIV) seropositivity were recorded. Results: The results found that only 39.7% of patients have positive DEXA scans characterized by low BMD (abbreviated as DX+) and 60.3 % with normal BMD (abbreviated as DX0). The average Functional Independence (FISH) score in DX+ patients is significantly lower than those in the DX0 group, and about 33.3% of patients in the DX+ group have limitation of movement (LOM), which is significantly higher than of patients in DX0 group and 70.4% of patients in DX+ group are presented with seropositive viral infection, which is significantly higher than 39% of patients in DX0 group. Conclusion: It can be concluded that hemophilic patients with seropositive viral infection and severe LOM may be at higher risk of developing low BMD.

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“…(2019) and Bordbar et al (2020) discovered that patients with low BMD had significantly higher incidences of HCV and HBV.…”

Section: Discussionmentioning

confidence: 99%

Association Between Low Bone Mineral Density in Hemophilia Patients and Musculoskeletal Function Impairments

2024

J Angiotherapy

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Bone and joint health in children with severe hemophilia A: A single-center, prospective case-control study from North India

Khan,

Zaka-ur-Rab,

Siddiqi

2024

Pediatric Hematology Oncology Journal

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Skeletal complications in patients with hemophilia: a single-center experience

Bordbar,

Beigipour,

Tahami

et al. 2023

J Orthop Surg Res

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Background Arthropathy is a common complication in patients with hemophilia. We examined the prevalence of this skeletal complication in patients with hemophilia who were registered at a Comprehensive Hemophilia Center in Shiraz, Southern Iran. Materials and Methods In this cross-sectional study, an orthopedic specialist visited 448 patients and conducted screenings for skeletal complications. The assessment included evaluating the type of hemophilia, disease severity, treatment modality, the presence of inhibitors, and the identification of skeletal complications. Results Ninety patients with hemophilia A, with a mean age (SD) of 31.6 (14.4) years, and 10 patients with hemophilia B, with a mean age of 30.5 (20.6) years, were assessed. The most frequently affected joints were the knee and ankle joints. In the univariate analysis, patients with severe disease were more likely to exhibit synovitis, a target joint, and bone disease compared to patients with non-severe disease. Additionally, a history of treated or active hepatitis and an annual bleeding rate showed significant associations with the target joint. In the multivariable logistic regression analysis, disease severity (OR 14.43, 95% CI 1.6–129.6) and a higher age at diagnosis (OR 1.06, 95% CI 1.00–1.13) increased the likelihood of developing osteoporosis. A history of hepatitis (OR 3.67, 95% CI 1.28–10.48) was identified as an independent risk factor for the target joint. Conclusion Skeletal complications are a common occurrence in hemophilia. Regular consultations with orthopedic specialists, focusing on bleeding control and hepatitis prevention, are essential for reducing the impact of this debilitating complication.

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Prevalence of Low Bone Mass in Patients with Hemophilia and Its Related Ractors in Southern Iran

Cited by 3 publications

References 32 publications

Association Between Low Bone Mineral Density in Hemophilia Patients and Musculoskeletal Function Impairments

Association Between Low Bone Mineral Density in Hemophilia Patients and Musculoskeletal Function Impairments

Bone and joint health in children with severe hemophilia A: A single-center, prospective case-control study from North India

Skeletal complications in patients with hemophilia: a single-center experience

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