Prevalence of low vitamin D levels in patients with Hidradenitis suppurativa in Jordan: A comparative cross-sectional study

Seetan, Khaled; Eldos, Batool; Saraireh, Muthanna; Al-Omari, Rami; Rubbai, Yousef; Jayyusi, Anas; Jubran, Maha Abu

doi:10.1371/journal.pone.0265672

Cited by 15 publications

(15 citation statements)

References 33 publications

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“…Research has demonstrated its critical role in epidermis repair and maintenance through its involvement in cell differentiation, proliferation and immune function 17,18 . Our results are consistent with those of Seetan et al (2022), who discovered that vitamin D is effective in treatment of hyperpigmentation disorders 19 . In contrast to the research which observed negligible effects on wound healing, our research suggested that vitamin D plays more prominent role in this regard 20 …”

Section: Discussionsupporting

confidence: 91%

“…17,18 Our results are consistent with those of Seetan et al (2022), who discovered that vitamin D is effective in treatment of hyperpigmentation disorders. 19 In contrast to the research which observed negligible effects on wound healing, our research suggested that vitamin D plays more prominent role in this regard. 20 The Vitamin D group exhibited the notable decrease in chloasma severity scores, which implied that vitamin D may have therapeutic potential in treatment of pigmentary disorders.…”

Section: Discussionsupporting

confidence: 91%

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Vitamin D and wound healing: Assessing skin barrier function and implications for chloasma treatment

Chen,

Liu,

Zhang

2024

International Wound Journal

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Chloasma, which is distinguished by irregularities in the pigmentation of skin, poses substantial challenge in the field of dermatology. The regulatory influence of vitamin D on the functions of skin cells implies that it may have the capacity to effectively treat chloasma and promote wound healing. To assess the efficacy of vitamin D in chloasma treatment and its impact on the function of skin barrier during the process of wound healing. The research spanned from April 2022 to September 2023, in Shanghai, China, examined 480 individuals who had been diagnosed with chloasma. A double‐blind, placebo‐controlled clinical trial was utilized to evaluate effectiveness of topical vitamin D3 in treatment of chloasma. Concurrently, randomized control trial investigated the effects of ingested vitamin D3 supplements on the process of wound healing. Transepidermal water loss (TEWL), chloasma severity score changes, wound size reduction and skin hydration levels were critical performance indicators. Statistically, the severity scores of chloasma decreased significantly in the vitamin D treatment group at 3 and 6 months compared with the placebo (p < 0.05). The Vitamin D group exhibited superior wound healing outcomes, including more substantial reduction in lesion size and enhanced skin barrier function, as evidenced by increased skin hydration and decreased TEWL (p < 0.05). Vitamin D substantially mitigated the severity of chloasma and has beneficial effect on wound healing and integrity of the skin barrier. Based on the results obtained, vitamin D exhibited promise as a therapeutic intervention in the field of dermatology, specifically in treatment of chloasma and promotion of wound recovery.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 91%

Vitamin D and wound healing: Assessing skin barrier function and implications for chloasma treatment

Chen,

Liu,

Zhang

2024

International Wound Journal

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“…Patients with HS were associated with vitamin D deficiency, which is consistent with the results of other studies 50,51 . A previous study reported that patients with HS are more likely to be vitamin D deficient than patients without HS 50 .…”

Section: Discussionsupporting

confidence: 91%

Epidemiology and comorbidity of hidradenitis suppurativa in Korea for 17 years: A nationwide population‐based cohort study

Lee

Heo

Lee

et al. 2023

The Journal of Dermatology

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Hidradenitis suppurativa (HS) is associated with various metabolic and autoimmune diseases. The epidemiology has been analyzed in various studies worldwide. However, epidemiological data on HS for Asian populations are limited. This study aimed to analyze the change in the prevalence and incidence of HS over 17 years in South Korea using the Korean National Health Insurance Service (NHIS) database. This study also evaluated the comorbidities in patients with HS. Population‐based data from the NHIS database of Korea were obtained between January 2003 and December 2019. Odds ratios were estimated to determine the association between comorbidities and HS during the study period. Hazard ratios for the risk of incident comorbidities in patients with HS were obtained using the multivariable Cox proportional hazard analysis. This study included 45 511 patients with HS and 910 220 controls matched for age, sex, insurance type, and income level. The incidence rate of HS per 1 000 000 person‐years in Korea increased from 11.69 in 2003 to 78.78 in 2019. The annual prevalence per 1 000 000 people also increased from 34.68 in 2003 to 140.10 in 2019, showing a similar trend. Many comorbidities, including atopic, metabolic and end‐organ, autoimmune/inflammatory, and psychiatric diseases were associated with HS at baseline. In many diseases, the risk of incident comorbidities in patients with HS was higher than that in controls. The incidence and prevalence of HS in Korea have increased over the past 17 years. Various comorbidities, including allergic diseases, hypertension, diabetes mellitus, dyslipidemia, myocardial infarction, chronic hepatitis and cirrhosis, chronic kidney disease, inflammatory bowel diseases, rheumatoid arthritis, vitamin D deficiency, and psychiatric diseases, were associated with HS. Physicians need to keep in mind and closely monitor these comorbidities in patients with HS.

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“…Interestingly, patients with HS have been shown to have low vitamin D levels, which seems to be correlated with disease severity [ 39 , 40 , 41 ]. By controlling proliferation and differentiation of epidermis and its structures (hair follicle in particular), vitamin D is able to regulate skin homeostasis [ 42 ].…”

Section: Gut Microbiome In Hsmentioning

confidence: 99%

Microbiome in Hidradenitis Suppurativa—What We Know and Where We Are Heading

Świerczewska

Lewandowski

Surowiecka³

et al. 2022

IJMS

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Recently, interest in the microbiome of cutaneous diseases has increased tremendously. Of particular interest is the gut-brain-skin axis proposed by Stokes and Pillsbury in 1930. The microbiome has been suggested in the pathogenesis of hidradenitis suppurativa, however the link between the commensals and the host is yet to be established. Across all studies, the increased abundance of Porphyromonas, Peptoniphilus, and Prevotella spp., and a loss of skin commensal species, such as Cutibacterium in HS lesions, is a consistent finding. The role of gut and blood microbiome in hidradenitis suppurativa has not been fully elucidated. According to studies, the main link with the intestine is based on the increased risk of developing Crohn’s disease and ulcerative colitis, however, further research is highly needed in this area. Lifestyle, dietary approaches, and probiotics all seem to influence the microbiome, hence being a promising modality as adjuvant therapy. The aim of this review was to present the latest reports in the field of research on skin, blood, and gut microbiome in terms of hidradenitis suppurativa.

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Prevalence of low vitamin D levels in patients with Hidradenitis suppurativa in Jordan: A comparative cross-sectional study

Cited by 15 publications

References 33 publications

Vitamin D and wound healing: Assessing skin barrier function and implications for chloasma treatment

Vitamin D and wound healing: Assessing skin barrier function and implications for chloasma treatment

Epidemiology and comorbidity of hidradenitis suppurativa in Korea for 17 years: A nationwide population‐based cohort study

Microbiome in Hidradenitis Suppurativa—What We Know and Where We Are Heading

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