Prevalence of lung cancer in chronic obstructive pulmonary disease: A systematic review and meta-analysis

Zhao, Guangbo; Li, Xuanlin; Lei, Siyuan; Zhao, Hao; Zhang, Hailong; Li, Jiansheng

doi:10.3389/fonc.2022.947981

Cited by 12 publications

(13 citation statements)

References 76 publications

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“…This suggested ongoing in ammation in the pulmonary tissue of COPD sufferers, which could heighten the risk of lung cancer two to sevenfold, independent of smoking history [4,21]. Smokers with impaired lung function face about a vefold increase in lung cancer incidence compared to those with preserved pulmonary performance [22]. Understanding these mechanisms is crucial as lung cancer remains a signi cant cause of illness and death among COPD patients.…”

Section: Discussionmentioning

confidence: 99%

Elucidating the Prognostic Biomarkers and Immune Correlations in the Co- occurrence of Chronic Obstructive Pulmonary Disease and Lung Squamous Cell Carcinoma

Hui,

Qi,

Ping

et al. 2024

Preprint

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Background: Chronic obstructive pulmonary disease (COPD) elevated the risk of lung squamous cell carcinoma (LUSC), but the underlying molecular links and their effects on disease progression were unclear. Methods: This study performed a comprehensive analysis of microarray and RNA-Seq data from six independent cohorts to identify key differentially expressed genes (DEGs) between COPD and LUSC patients. It conducted survival analysis using the TCGA-LUSC dataset and constructed a risk prediction model for the identified DEGs through LASSO regression, accounting for smoking history in LUSC-TCGA patients. The immune correlations and tumor immunophenotype profiling of the risk model were further analyzed. Results: Distinct gene expression profiles were identified in patients with both COPD and LUSC compared to those with either condition alone, with seven genes showing significant dysregulation. This suggested a unique molecular signature for combined disease pathology. PTPN3 and ADH1C were pinpointed as potential prognostic biomarkers using a LASSO model. These genes also demonstrated negative correlations with various immune cells and positive correlations with tumor-promoting processes. Conclusion: This study reveals the molecular connection between COPD and LUSC, pinpointing biomarkers for disease evolution and therapeutic response, and emphasizes the intricate treatment dynamics due to COPD's genetic and immune influences on LUSC prognosis

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Section: Discussionmentioning

confidence: 99%

Elucidating the Prognostic Biomarkers and Immune Correlations in the Co- occurrence of Chronic Obstructive Pulmonary Disease and Lung Squamous Cell Carcinoma

Hui,

Qi,

Ping

et al. 2024

Preprint

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“…The incidence of AE-IPF was similar among ve studies in Japan [21][22][23][24][25] , but the study involved fewer regions and could not identify regional differences through subgroup analysis. This may be related to different levels of economic development, population aging, and medical conditions in different regions [31] .…”

Section: Discussionmentioning

confidence: 99%

The incidence of acute exacerbation of idiopathic pulmonary fibrosis: A systematic review and meta-analysis

wang,

Ji,

et al. 2024

Preprint

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Background: Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease with a high incidence of acute exacerbation and an increasing mortality rate. Currently, treatment methods and effects are limited. Therefore, we conducted a meta-analysis of the incidence of acute exacerbation in patients with IPF, hoping to provide reference for the prevention and management of IPF. Methods: We systematically searched the PubMed, Embase, Cochrane Library and Web of Science databases. From the creation of the database to the cohort study on April 3, 2023, we collected studies on the incidence of acute exacerbation of IPF patients, and used Stata software (version 16.0) for meta analysis. We used the Newcastle Ottawa Quality Assessment Scale (NOS) to assess the risk of bias for each study. We calculated the incidence of acute exacerbation in IPF patients and analyzed the risk and prognostic factors for acute exacerbation in IPF patients. Results: A total of ten cohort studys on the incidence of AE-IPF were included, including 11855 IPF patients. The results showed that the incidence of acute exacerbation within one year was 9%; the incidence of acute exacerbation within 2 years is 13%; the incidence of acute exacerbation within 3 years is 19%; the incidence of acute exacerbation within 4 years is 11%. In addition, one study reported an acute exacerbation rate of 1.9% within 30 days. The incidence of acute exacerbation within ten years reported in one study was 9.8%. One study included a retrospective cohort study and a prospective cohort study. In this study, the prospective cohort study showed that the incidence of acute exacerbation within 3 years was 18.6%, similar to the results of the retrospective cohort study meta-analysis. Conclusions: Our system evaluation and meta-analysis results show that the incidence of AE-IPF is relatively high. Therefore, sufficient attention should be paid to the research results, including the management and prevention of the disease, in order to reduce the risk of AE. Systematic review registration: PROSPERO, identifier CRD42022341323.

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“…The prevalence of lung cancer in COPD patients is reported to be more than 5%; it is reported to be 1.5 times higher in people who smoke or have smoked before. Also, this rate is higher in men than in women [ 19 ]. Three of the important risk factors for this disease are smoking, household air pollution exposure, and ambient particles.…”

Section: Discussionmentioning

confidence: 99%

The study of trends in mortality of respiratory system cancers in Babol, North of Iran (2013-2021)

Hosseini-Berneti,

Karami,

Bayani

et al. 2023

Multidis Res Med

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Background: In Iran, cancers are known as the second leading cause of death, among which respiratory system cancers are particularly important because lung cancer is the second most common cause of death in this country. This study aimed to estimate the crude and age-standardized mortality and its trends during 9 years in the northern city of Iran, Babol.Methods: In this cross-sectional study, all the recorded deaths due to respiratory system cancers in Babol during the years 2013-2021 on the Classification of Causes of Deaths and Death Registration System of Babol University of Medical Sciences were taken into consideration, and the population estimate was based on the latest census. Finally, the crude and age-standardized rates of mortality and trends of cancer incidents were calculated.Results: In general, 393 deaths with an overall mean age of 67.8±3.9 years have happened due to respiratory system cancers. The crude and standardized rates of respiratory system cancers increased from 6.5 and 5.5 per hundred thousand people in 2013 to 9.1 and 7.8 per hundred thousand people in 2021, respectively. With each decade in age, their trends increased significantly in men (p=0.024) and remained constant in women (p=0.262). In examining the trend of respiratory system cancers, we found an increasing trend for lung cancer and a constant trend for larynx and oropharynx cancers. There was also a decreasing trend for hypopharyngeal cancer.Conclusions: The age-standardized rate and trend of respiratory system cancers are increasing. Therefore, it is important to prevent their prevalence by reducing the risk factors and increasing the general awareness of risks and timely diagnosis.

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Prevalence of lung cancer in chronic obstructive pulmonary disease: A systematic review and meta-analysis

Cited by 12 publications

References 76 publications

Elucidating the Prognostic Biomarkers and Immune Correlations in the Co- occurrence of Chronic Obstructive Pulmonary Disease and Lung Squamous Cell Carcinoma

Elucidating the Prognostic Biomarkers and Immune Correlations in the Co- occurrence of Chronic Obstructive Pulmonary Disease and Lung Squamous Cell Carcinoma

The incidence of acute exacerbation of idiopathic pulmonary fibrosis: A systematic review and meta-analysis

The study of trends in mortality of respiratory system cancers in Babol, North of Iran (2013-2021)

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