Prevalence of macro- and microvascular complications in patients with type 2 diabetes and kidney disease with or without albuminuria in a single Chinese Diabetes Centre

Wu, Dingting; Xuan, Yanyan; Yu, Rong; Feng, Xiaoqi; Zhu, Yinchao; Jia, Chengfang; Li, Jun; Li, Hong; Li, Lianxi; Dong, Xuehong

doi:10.1177/1479164115610247

Cited by 13 publications

(9 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Few reports described the clinical characteristics of normoalbuminuric DKD with vascular complications. A previous report compared these characteristics with the characteristics of patients with micro-/macroalbuminuria [15]. Tingjun Wang et al [24] also reported that low-grade albuminuria is related to LV hypertrophy and diastolic dysfunction in patients with hypertension; we also find similar relation, but it did not show the joint relationship between albuminuria and eGFR.…”

Section: Features Of Normoalbuminuria With Vascular Complicationssupporting

confidence: 43%

“…Hence, the joint relationship of albuminuria and eGFR with vascular diseases has not been elaborated, and different conclusions have been obtained [13,14]. Wu et al [15] investigated the relationship between DR, neuropathy, and low ankle-brachial index (ABI) in patients with T2D ac-companied by mild to moderate CKD. They found that the prevalence of diabetic retinopathy (DR) was graded according to the decline in the eGFR in patients with albuminuria, while the prevalence of peripheral arterial disease (PAD) gradually increased in patients with normoalbuminuria [15].…”

Section: Introductionmentioning

confidence: 99%

“…Wu et al [15] investigated the relationship between DR, neuropathy, and low ankle-brachial index (ABI) in patients with T2D ac-companied by mild to moderate CKD. They found that the prevalence of diabetic retinopathy (DR) was graded according to the decline in the eGFR in patients with albuminuria, while the prevalence of peripheral arterial disease (PAD) gradually increased in patients with normoalbuminuria [15]. However, further research is required to confirm the results with large sample sizes and analyze the factors influencing complications of diabetes mellitus.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Stronger Association of Albuminuria with the Risk of Vascular Complications than Estimated Glomerular Filtration Rate in Type 2 Diabetes

Hong¹,

Huang²,

Zhang³

et al. 2021

Kidney Blood Press Res

View full text Add to dashboard Cite

Introduction: Albuminuria is a risk factor for macro- and microvascular complications of type 2 diabetes (T2D).With an increasing trend of normoalbuminuria, however, of the 2 predictors – estimated glomerular filtration rate (eGFR) and urine albumin-to-creatinine ratio (UACR) – which one is a better predictor of vascular complications of T2D is not clear. Objective: This study aimed to compare the impacts of albuminuria and eGFR on patients with T2D associated with micro- and macrovascular complications. Methods: This retrospective study recruited 4,715 patients with T2D and grouped them based on the values of UACR (high UACR: ≥30 mg/g, low UACR: <30 mg/g) and eGFR (mL/[min × 1.73 m2]) (G1: eGFR ≥ 90; G2: eGFR = 60–89; G3–5: eGFR < 60) from April 2008 to November 2018. Logistic regression analysis was carried out for risk factors in patients with diabetic retinopathy (DR), diabetic peripheral neuropathy (DPN), peripheral arterial disease (PAD), left ventricular remodeling, diastolic disorders, and carotid atherosclerotic plaque in 6 different groups: low UACR + G1 (control group), low UACR + G2, low UACR + G3–5, high UACR + G1, high UACR + G2, and high UACR + G3–5. Patients were grouped according to the change in the UACR value (UACR-decreased group: ≤−30%, UACR-stable group: −30 to 30%, and UACR-increased group ≥30%), eGFR value (eGFR-decreased group: >3%, and eGFR-stable group: ≤3%) and followed up. Results: Compared with the control group, patients with higher albuminuria and lower eGFR had higher adjusted odds ratio (OR) trends of complications, especially in the high UACR + G3–5 group. The OR of 2.010, 3.444, 1.633, 2.742, and 3.014 were obtained for DR, DPN, PAD, left ventricular remodeling, and diastolic disorders, respectively. No statistically significant difference was found in the risk of complications within each one of 2 phenotypes, regardless of the change in the eGFR. After grouping by eGFR, the regression analysis of the urinary protein level in each stage revealed that a majority of complications had a statistically significant difference, except for DR and PAD in the high UACR + G3–5 group. DR in the follow-up study had a higher risk in the UACR-stable/increased group than the UACR-decreased group (UACR stable: OR = 2.568; 95% confidence interval (CI): 1.128–5.849; p = 0.025; UACR increased: OR = 2.489; 95% CI: 1.140–5.433; p = 0.022). Conclusion: UACR is a more predictive risk factor for diabetic complications compared with a reduced eGFR.

show abstract

Section: Features Of Normoalbuminuria With Vascular Complicationssupporting

confidence: 43%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Stronger Association of Albuminuria with the Risk of Vascular Complications than Estimated Glomerular Filtration Rate in Type 2 Diabetes

Hong¹,

Huang²,

Zhang³

et al. 2021

Kidney Blood Press Res

View full text Add to dashboard Cite

show abstract

“…Renal complications such as clinical nephropathy and chronic kidney disease (CKD) also contribute to the clinical burden in patients with T2D. These complications are affected by disease duration and patient age, with prevalence reported between 1%-25% in EMG [115,116], and 5%-20% in EST markets [116,117]. Variations in those numbers have been observed, mostly due to differences in diagnostic practices as well as diseases durations.…”

Section: Epidemiology: Complicationsmentioning

confidence: 99%

“…Due to heterogeneity in patient populations and diagnostic practices, no clear trends were observed between EMG and EST markets with respect to CKD or nephropathy epidemiology. Prevalence of nephropathy is known to be influenced by the other co-morbidities such as obesity and hypertension [116,117], the latter being a common and major contributing factor to the development of renal disease in T2D patients [119,120]. Crosssectional studies from EST and EMG markets which look into the characteristics of CKD patients show similarities in terms of severity distribution, with 60-90% of CKD patients being classed as stage 1 or 2 [121,122].…”

Section: Epidemiology: Complicationsmentioning

confidence: 99%

Burden of disease and costs associated with type 2 diabetes in emerging and established markets: systematic review analyses

Alzaid¹,

Guevara²,

Beillat

et al. 2020

Expert Review of Pharmacoeconomics & Outcomes Research

View full text Add to dashboard Cite

Objectives: To estimate the clinical and economic burden of type 2 diabetes (T2D) in established (EST) and emerging markets (EMG). Methods: Three systematic literature reviews were conducted in MEDLINE and Embase to capture all relevant publications reporting 1) the epidemiology of T2D and complications in T2D and 2) the economic burden of T2D and associated complications. Results: In total, 294 studies were included in this analysis. Evidence indicates a high and increasing overall prevalence of T2D globally, ranging up to 23% in EMG markets and 14% in EST markets. Undiagnosed cases were higher in EMG versus EST markets (up to 67% vs 38%), potentially due to a lack of education and disease awareness in certain regions, that could lead to important clinical and economic consequences. Poor glycemic control was associated with the development of several complications (e.g. retinopathy, cardiovascular diseases and nephropathy) that increase the risk of morbidity and mortality. Direct costs were up to 9-fold higher in patients with vs without T2D-related complications. Conclusions: The burden of T2D, related complications and inherent costs are higher in emerging versus established market countries. This review explores potential strategies to reduce costs and enhance outcomes of T2D treatment in developing countries.

show abstract

Diabetic Chronic Kidney Disease in Type 2 Diabetes Mellitus (Albuminuric/Non-albuminuric)

Roumeliotis

Mallamaci

Zoccali

2023

Updates in Hypertension and Cardiovascular Protection

View full text Add to dashboard Cite

Prevalence of macro- and microvascular complications in patients with type 2 diabetes and kidney disease with or without albuminuria in a single Chinese Diabetes Centre

Cited by 13 publications

References 37 publications

Stronger Association of Albuminuria with the Risk of Vascular Complications than Estimated Glomerular Filtration Rate in Type 2 Diabetes

Stronger Association of Albuminuria with the Risk of Vascular Complications than Estimated Glomerular Filtration Rate in Type 2 Diabetes

Burden of disease and costs associated with type 2 diabetes in emerging and established markets: systematic review analyses

Diabetic Chronic Kidney Disease in Type 2 Diabetes Mellitus (Albuminuric/Non-albuminuric)

Contact Info

Product

Resources

About