Prevalence of malaria parasitaemia in transfused donor blood in Benin City, Nigeria

Ibhanesebhor, Samuel; Otobo, Emamuzo; Ladipo, O. A.

doi:10.1080/02724936.1996.11747810

Cited by 26 publications

(22 citation statements)

References 6 publications

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“…She was born at term by normal vaginal delivery with a birth weight of 3100 g. Because of her severe anemia (data not available) she received a blood transfusion 1 day before her recruitment into the study. Since donor blood is not screened for malaria in Tanzania, we had to exclude the baby from our study (Ibhanesebhor et al 1996). She was eventually treated with chloroquine and survived.…”

Section: Resultsmentioning

confidence: 99%

Detection of congenital malaria by polymerase-chain-reaction methodology in Dar es Salaam, Tanzania

Adachi¹,

Manji

Ichimi

et al. 2000

Parasitol Res

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The examination of congenital malaria was performed by Giemsa staining and polymerase-chain-reaction (PCR) methodology. We randomly selected 298 neonates who had been admitted to Muhimbili Medical Center (MMC) at Dar es Salaam, Tanzania. One baby among all the enrolled neonates was recognized as having a congenital malaria infection, which gave a prevalence of 0.33%. The present result was 5-fold the clinically recognized prevalence of congenital infection with malaria in the ward. The PCR method identified two cases, one of which was negative as determined by the Giemsa-staining method. Therefore, the PCR method was useful for the detection of scant amounts of malarial parasites in numerous blood samples. The screening of malaria by a sensitive PCR method contributes to reduce the mortality of asymptotic neonates in particular.

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Section: Resultsmentioning

confidence: 99%

Detection of congenital malaria by polymerase-chain-reaction methodology in Dar es Salaam, Tanzania

Adachi¹,

Manji

Ichimi

et al. 2000

Parasitol Res

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“…Other similar studies in Nigeria with high malaria prevalence among blood donors abound (Ibhanesebho et al, 1996;Okocha et al, 2005;Uneke et al, 2006). In Onitsha, climate and vegetation are consistent with tropical rainforest.…”

Section: Discussionmentioning

confidence: 99%

“…Parasitological analysis was confirmed by independent experienced microscopists who were unaware of each result according to the World Health Organisation recommended procedures. The ABO/Rhesus phenotypes were performed for all subjects using the slide method (Ibhanesebho et al, 1996), with commercially available reagents (Murex. Inc. Dartford.…”

Section: Study Population Techniques and Analysismentioning

confidence: 99%

Malaria Infection Among Blood Donors in Onitsha Urban, Southeast Nigeria

Ekwunife¹,

Ozumba²,

Eneanya³

et al. 2011

Sierra Leone j. biomed. res.

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Blood safety is a major issue of global concern in transfusion medicine especially in developing countries, where national blood transfusion policies and services as well as financial resources are lacking or inadequate. Transfusion-transmitted malaria is a potential health hazard but is often neglected in many malarious areas. Malaria infection among blood donors in Onitsha urban, Southeast Nigeria was studied between August and October 2008. Venous blood of donors was screened for malaria parasites using Giemsa-stained thick and thin blood films. The ABO and Rhesus phenotypes were classified using a haemaglutination standard test and demographic data of donors documented. Of the 410 blood donors analysed, 304 (74.1%) were infected. Plasmodium falciparium was identified in all positive cases and mixed infection with P. malariae was seen in 5(1.6%) cases. Infection significantly varied with age and not with sex and occupation (p<0.05). People with blood group O + showed significantly higher rate of infection (p<0.05). Since there is scarcity of voluntary donors in Nigeria, donor deferral done in non-malarial endemic regions cannot be practiced in Nigeria. The high prevalence of asymptomatic malaria in this area, suggests the need for careful screening of blood samples for malaria parasites. Positive samples should be indicated on the blood packs and transfusion of malaria positive blood requires the administration of curative dose of antimalarials to the patient. Commercial donors should be freely given mosquito treated bed nets and be encouraged to sleep under them.

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“…In Sub-Saharan Africa, where blood donors are usually not screened for malarial parasites, this study shows that the platelet count can play a useful role in screening out blood donors with asymptomatic malaria as a blood donor with a platelet count ! 150,000/ l is more likely to have malarial infection compared to one with a count 6 150,000/ l. Although the current standard practice is to administer curative regimens of antimalarial drugs to all recipients of blood transfusions, the use of platelet counts can increase the chances of administering Plasmodium-free blood particularly to nonimmune patients among whom cases of transfusion malaria have been reported [21] .…”

Section: Discussionmentioning

confidence: 99%

Impact of Asymptomatic Malaria on Some Hematological Parameters in the Iwo Community in Southwestern Nigeria

Igbeneghu

Odaibo²,

Olaleye³

2011

Med Princ Pract

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Objective: To determine the prevalence of asymptomatic malaria among prospective blood donors and its effect on some hematological parameters. Subjects and Methods: Six hundred sixty-eight seemingly healthy individuals (501 men and 167 women) ≧16 years of age and without clinical symptoms in Iwo, Southwestern Nigeria, were screened for this study. A sample of 5 ml of blood was drawn from each participant for examination of malaria parasites and a full blood count. Thick and thin Giemsa-stained blood smears were prepared for malaria parasite identification and quantification. Estimations of hematocrit, hemoglobin concentration, and platelet and leukocyte counts were made using an automated Coulter counter (STKS model). Results: Out of the 668 participants examined, 141 (21.1%) were positive for malarial parasitemia. The parasite rate was significantly higher in men (25.5%) than in women (7.8%) (χ² = 23.29, p < 0.001) and it was significantly associated with age (χ² = 33.69, p < 0.001). Parasitemic participants had significantly lower mean values of hematocrit, hemoglobin concentration, and total leukocyte and platelet counts compared to aparasitemic individuals (t = 3.5, p < 0.001; t = 2.0, p = 0.04; t = 4.4, p < 0.001, and t = 5.3, p < 0.001, respectively). A low platelet count (<150 × 10⁹/l) was significantly associated with malarial infection (OR 4.0; 95% CI 2.6–6.1). A person with a platelet count <150 × 10⁹/l was 4 times more likely to have asymptomatic malarial infection than one with a count ≧150 × 10⁹/l. Conclusion: Asymptomatic malaria is prevalent among blood donors in the study area and is associated with thrombocytopenia.

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Prevalence of malaria parasitaemia in transfused donor blood in Benin City, Nigeria

Cited by 26 publications

References 6 publications

Detection of congenital malaria by polymerase-chain-reaction methodology in Dar es Salaam, Tanzania

Detection of congenital malaria by polymerase-chain-reaction methodology in Dar es Salaam, Tanzania

Malaria Infection Among Blood Donors in Onitsha Urban, Southeast Nigeria

Impact of Asymptomatic Malaria on Some Hematological Parameters in the Iwo Community in Southwestern Nigeria

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