Prevalence of Maternal and Neonatal Infections in a Developing Country: Possible Low‐Cost Preventive Measures

Urrutia, Juan J.; Sosa, Roberto; Kennell, John H.; Klaus, Marshall H.

doi:10.1002/9780470720608.ch11

Cited by 6 publications

(3 citation statements)

References 10 publications

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“…Toxoplasma gondii IgG seroprevalence was higher than most estimates previously reported in Guatemala, though T . gondii IgM seroprevalence was similar to that found in a previous study by Urrutia et al [ 29 , 33 ]. Sinibaldi and de Ramirez reported that T .…”

Section: Discussionsupporting

confidence: 91%

“…More than two-thirds of the women in our cohort were seropositive for T. gondii IgG, indicating a previous infection. Toxoplasma gondii IgG seroprevalence was higher than most estimates previously reported in Guatemala, though T. gondii IgM seroprevalence was similar to that found in a previous study by Urrutia et al [29,33]. Sinibaldi and de Ramirez reported that T. gondii seropositivity increased with age in their cohort and women between 24 to 26 years of age were at higher risk of contracting a primary T. gondii infection compared to the other participants in the study, important considerations given that the mean age of our cohort was 24.5 years.…”

Section: Discussionsupporting

confidence: 88%

“…Nonetheless, it should be noted that Guatemala and other countries in Central America are often not captured in systematic reviews of TORCH pathogens, as many countries do not have population-level estimates or studies of non-HIV TORCH incidence and prevalence [ 22 , 23 , 28 ]. Most studies of TORCH pathogens in humans in Guatemala are several decades old; we were unable to find recently published studies investigating TORCH in pregnant women in Guatemala [ 29 – 33 ]. Data on HIV, syphilis, and rubella in Guatemala are more recent [ 34 – 36 ].…”

Section: Introductionmentioning

confidence: 99%

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Seroprevalence of high incidence congenital infections among pregnant women in Coatepeque, Guatemala and surrounding areas, 2017–2018

et al. 2023

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Maternal infections during pregnancy can potentially cause birth defects and severe adverse effects in infants. From 2017 to 2018, we investigated the seroprevalence of five antibodies among 436 mother-infant pairs enrolled in a pregnancy cohort study in Coatepeque, Guatemala. Upon enrollment (< 20 weeks gestational age) and shortly after delivery, we measured the prevalence of IgG and IgM antibodies against Toxoplasma gondii (T. gondii), rubella, and cytomegalovirus (CMV) in mothers and newborns and used rapid tests to detect HIV and syphilis (Treponema pallidum) in mothers. The mean cohort age was 24.5 years. Maternal T. gondii IgM and IgG seropositivity was 1.9% and 69.7%, respectively. No women were positive for HIV, syphilis, or rubella IgM. Maternal rubella IgG seropositivity was 80.8% and significantly increased with age. Maternal CMV IgM and IgG seropositivity were 2.3% and 99.5%, respectively. Of the 323 women tested at both timepoints, IgM reactivation occurred in one woman for T. gondii infection and in eight for CMV. No newborn was seropositive for CMV IgM or rubella IgM. One newborn was seropositive for T. gondii IgM. Congenital T. gondii and CMV infections are important public health issues for pregnant women, newborns, and healthcare providers in Coatepeque and Guatemala.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 88%