Prevalence of maternal measles antibody and its associated factors among infants in Coastal Karnataka, India

Sathiyanarayanan, S; Kumar, Pawan; Rao, Chythra R; Kumar, Arun; Kamath, Asha; Kamath, Veena G

doi:10.4103/ijcm.ijcm_259_19

Cited by 2 publications

(1 citation statement)

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“…This is not the first study highlighting the problem of infants remaining unprotected from measles, prior to the age of vaccination. Besides our own studies highlighted above [ 21 , 22 ], a study in 250 infants showed that only 25 (10%) had IgG antibodies just prior to vaccination [ 28 ]. Similarly, another cross-sectional study of 120 infants showed that 85% lacked antibodies prior to vaccination at the age of 9–10 months [ 29 ].…”

Section: Discussionmentioning

confidence: 87%

Maternally transmitted anti-measles antibodies, and susceptibility to disease among infants in Chandigarh, India: A prospective birth cohort study

Mathew,

Wagner,

Ratho

et al. 2023

PLoS ONE

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Prior to the age of measles vaccination, infants are believed to be protected against measles by passively transferred maternal antibodies. However, the quantity and quality of such protection have not been well established in the Indian setting. We undertook this study to characterize the transfer and decline in maternal anti-measles antibodies among infants, and determine their susceptibility to measles. In this population-based, birth-cohort study, we enrolled pregnant women and their newborn infants, from a catchment area of 30 Anganwadis in Chandigarh, India. We collected maternal blood at delivery, and infant blood samples at birth, and 3, 6, and 9 months of age. Anti-measles IgG antibodies were measured using quantitative ELISA. We assessed antibody decline using log-linear models. In total, 428 mother-infant dyads were enrolled, and data from 413 dyads were analyzed. At birth, 91.5% (95% CI: 88.8, 94.2) of infants had protective antibody levels, which declined to 26.3% (95% CI: 21.0%, 31.9) at 3 months, 3.4% (95% CI: 0.9, 5.9) at 6 months, and 2.1% (95% CI: 0.1, 4.1) at 9 months. Younger mothers transferred lower levels of antibodies to their infants. We concluded that the majority of infants are susceptible to measles as early as three months of age, much earlier than their eligibility to receive measles vaccination.

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Section: Discussionmentioning

confidence: 87%