Prevalence of mcr-1 in commensal Escherichia coli from French livestock, 2007 to 2014

Abstract

Colistin resistance was investigated in 1,696 isolates collected from 2007 to 2014 within the frame of the French livestock antimicrobial resistance surveillance programme. The mcr-1 gene was detected in all commensal Escherichia coli isolates with a minimum inhibitory concentration to colistin above the 2 mg/L cut-off value (n=23). In poultry, mcr-1 prevalence was 5.9% in turkeys and 1.8% in broilers in 2014. In pigs, investigated in 2013, this prevalence did not exceed 0.5%. These findings support that mcr-1 has spread in French livestock.

Prevalence of mcr-1 in the Cecal Contents of Food Animals in the United States

“…This is considerably lower than prevalences recently reported for food animals in Europe (12) and Asia (13). Characteristics of the two isolates are listed in Table 1.…”

Epidemiology of antimicrobial resistance in bloodstream infections

“…82 Plasmid-mediated colistin resistance (via mcr-1 colistin resistance gene) has recently described in E. coli isolates worldwide from mainly livestock and less frequently in human samples. [84][85][86][87][88][89] The implications of this finding may be horrendous since the offending plasmid can easily be transferred between E. coli strains including those with epidemic potential (e.g. ST131) and to K. pneumoniae and P. aeruginosa.…”

Travelers Can Import Colistin-Resistant Enterobacteriaceae, Including Those Possessing the Plasmid-Mediated mcr-1 Gene

“…These strains (especially Escherichia coli) have been isolated worldwide from humans (1,(3)(4)(5)(6)(7)(8)(9)(10), food-producing animals (4,6,(11)(12)(13)(14), the food chain (7,10,(15)(16)(17), and the environment (4,15). However, most of these studies searched for mcr-1 in previously stored extended-spectrum cephalosporinresistant Enterobacteriaceae (ESC-R-Ent) (8,12,13,15,17).…”