Prevalence of mental health conditions among people living with HIV during the COVID‐19 pandemic: A rapid systematic review and meta‐analysis

Lee, Kai Wei; Ang, Chin-Siang; Lim, Sin How; Siau, Ching Sin; Ong, Derek Lai Teik; Ching, Siew Mooi; Ooi, Pei Boon

doi:10.1111/hiv.13299

Cited by 23 publications

(21 citation statements)

References 65 publications

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“…Therefore, it is reasonable that analysis of EFV-induced neuropsychiatric adverse events in previous studies was limited by the follow-up durations. As for the prevalence of depression and anxiety, we found higher results (15.6% and 14.615.3`% respectively) compared to that in previous study in 2017 2015 (12.939.6% and 12.849.7% [ 19 ] respectively) in China using HADS, however, our results werelower to contemporaneous reports in 2020 (16.9% and 23.0%) according to a meta-analysis [ 33 ]. The prevalence of depression and anxiety of this study may have different outcomes from other studies worldwide contemporaneously for different reasons: 1) different scales are used.…”

Section: Discussioncontrasting

confidence: 90%

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Anxiety, depression, and sleep disturbances among people on long-term efavirenz-based treatment for HIV: a cross-sectional study in Beijing, China

Xiao

Liu

et al. 2022

BMC Psychiatry

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Background Efavirenz (EFV)-induced neuropsychiatric toxicity bothers people living with HIV (PLHIV). Neuropsychiatric adverse effects of EFV may differ by length of time on EFV-based antiretroviral treatment (ART). Methods A cross-sectional, single-center study was conducted at Beijing Ditan Hospital in China from June–August 2020 among ART-experienced PLHIV who were on long-term EFV-based ART. 424 eligible virological suppressed participants were enrolled and divided into four groups according to time on EFV-based ART: group A (0.5 ≤ ART < 2 year), B (2 ≤ ART < 4 year), C (4 ≤ ART < 6 year), and D (ART ≥ 6 year). The questionnaires about 12-item Short Form Health Survey (SF-12), Hospital Anxiety and Depression Scale (HADS) and Pittsburgh Sleep Quality Index (PSQI) were administered to assess neuropsychiatric adverse events of EFV among different groups. Results Overall mental component summary scores (MCS) of SF-12 in PLHIV was 50.2, which was lower than general population. Overall prevalence of anxiety, depression and sleep disturbances was 15.6%, 15.3% and 58%, respectively. Prevalence of anxiety, depression and sleep disturbances did not vary significantly between the time-on-ART groups. Anxiety, depression, sleep disturbances had no correlation with time on EFV-based ART or CD4+ T cells counts. Conclusions In ART-experienced PLHIV in China, neuropsychiatric adverse events exist persistently and prevalence do not significantly change with prolonged time on EFV-based ART. The prevalence of sleep disturbances was high, suggesting that clinicians should pay more attention to long-standing psychiatric health to perform early and effective interventions.

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Section: Discussioncontrasting

confidence: 90%

“…Four hundred twenty-four PLHIV were enrolled, the mean age was 34 years (IQR, [30][31][32][33][34][35][36][37][38][39][40], 416 (98.1%) were male, and 398 (94.9%) were Han. The mean body mass index (BMI) was 22.8 kg/m 2 (IQR, 20.8-24.7).…”

Section: Baseline Characteristicsmentioning

confidence: 99%

Anxiety, depression, and sleep disturbances among people on long-term efavirenz-based treatment for HIV: a cross-sectional study in Beijing, China

Xiao

Liu

et al. 2022

BMC Psychiatry

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“…Also it was found that depression is highly prevalent among PLWH by representing racial or sexual minorities (Rendina et al., 2018). Finally, recent years have brought about additional global stress in the form of the coronavirus (COVID‐19) pandemic, which particularly hampered the mental functioning of this vulnerable population (Lee et al., 2021). Thus, in the present study, our aim was to examine the trajectories of depressive symptom changes among PLWH during the critical period of the COVID‐19 pandemic and its covariates in the form of perceived HIV/AIDS stigma and emotional support.…”

Section: Introductionmentioning

confidence: 99%

“…Within this latter group we can include PLWH (May & Fullilove, 2022). In light of the recent report (WHO, 2022), during the COVID‐19 pandemic, PLWH have experienced substantial disruptions in their everyday functioning, including barriers to healthcare due to COVID‐19‐exclusive transformations of hospitals, delays in HIV testing, problems with HIV treatment, or a lack of anonymity due to telemedicine services (Lee et al., 2021). In addition, several studies have found that PLWH as a group suffered particularly strongly from disruptions in their social life during the pandemic, including isolation and related depressive and suicidal thoughts (Sun et al., 2020).…”

Section: Introductionmentioning

confidence: 99%

“…Nevertheless, the majority of studies on social support among PLWH are also limited by various shortcomings, such as dominance of cross-sectional assessment and lack of differentiating between social support characteristics (Qiao et al, 2014). Also, the available research on depression and stigma conducted among PLWH during the COVID-19 pandemic provides only cross-sectional data (see review: Lee et al, 2021). Thus, to the best of our knowledge, RZESZUTEK AND GRUSZCZYŃSKA our longitudinal study is the first to examine trajectories of change in depression symptoms among PLWH during universal, socially shared and chronic stress, which could act as both a trigger and an amplifier for worsening of emotional functioning (Ross, 2017).…”

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Depression during the COVID‐19 pandemic among people living with HIV: Are low HIV/AIDS stigma and high perceived emotional support protective resources?

Rzeszutek

Gruszczyńska

2023

Stress and Health

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This study has two objectives: first, to examine changes in depressive symptoms among people living with HIV (PLWH) during the COVID‐19 pandemic and, second, to verify the role of HIV/AIDS stigma and perceived emotional support (PES) in the heterogeneity of these changes. The participants were 392 people with a medical diagnosis of HIV who have undergone antiretroviral therapy. Depression was measured at three time points with 6‐month intervals using the Centre for Epidemiological Studies Depression Scale (CES‐D). PES was evaluated with the Berlin Social Support Scales, and HIV/AIDS‐related stigma was assessed with the Berger HIV Stigma Scale. Latent growth class modelling identified four trajectories of depression over the study period: three stable (very high, high, and very low) and one increasing. Both the very high and high stable trajectories had baseline values above the CES‐D cut‐off point for depression, suggesting that 57.6% of the sample was likely to be diagnosed with depression. After controlling for sociodemographic and clinical variables, stigma and PES were found to be significant covariates of the obtained trajectories; however, they did not protect against an increase in depression symptoms. There was no overall increase in depression symptoms among the PLWH participants during the pandemic, but this change in depression symptoms was heterogeneous. We observed the potential development of depression in initially well‐functioning individuals despite their personal resources differing only slightly from those who remained resilient.

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HIV Testing Disruptions and Service Adaptations During the COVID-19 Pandemic: A Systematic Literature Review

Mude,

Mwenyango,

Preston

et al. 2023

AIDS Behav

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Access to treatment and care in safe clinical settings improves people’s lives with HIV. The COVID-19 pandemic disrupted vital HIV programs and services, increasing the risk of adverse health outcomes for people with HIV and HIV transmission rates in the community. This systematic literature review provides a meta-analysis of HIV testing disruptions and a synthesis of HIV/AIDS services adapted during COVID-19. We searched scholarly databases from 01 January 2020 to 30 June 2022 using key terms on HIV testing rates and services during the COVID-19 pandemic. The process of how the included articles were identified, selected, appraised, and synthesised was reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We included 17 articles that reported changes in HIV testing during the COVID-19 pandemic and 22 that reported adaptations in HIV/AIDS services. We found that HIV testing decreased by 37% during the search period because of the COVID-19 pandemic. Service providers adopted novel strategies to support remote service delivery by expanding community antiretroviral therapy dispensing, setting up primary care outreach points, and instituting multi-month dispensing services to sustain client care. Therefore, service providers and policymakers should explore alternative strategies to increase HIV testing rates impacted by COVID-19 and leverage funding to continue providing the identified adapted services.

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Prevalence of mental health conditions among people living with HIV during the COVID‐19 pandemic: A rapid systematic review and meta‐analysis

Cited by 23 publications

References 65 publications

Anxiety, depression, and sleep disturbances among people on long-term efavirenz-based treatment for HIV: a cross-sectional study in Beijing, China

Anxiety, depression, and sleep disturbances among people on long-term efavirenz-based treatment for HIV: a cross-sectional study in Beijing, China

Depression during the COVID‐19 pandemic among people living with HIV: Are low HIV/AIDS stigma and high perceived emotional support protective resources?

HIV Testing Disruptions and Service Adaptations During the COVID-19 Pandemic: A Systematic Literature Review

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