Prevalence of Metabolic Syndrome and Its Parameters and Their Correlations With Psoriasis Duration, Severity, and Sleep Quality In Psoriasis Patients: A Cross-Sectional Study

Abstract

Background: Psoriasis is an inflammatory skin disease that may lead to comorbidities, including metabolic syndrome (MS).
 Objective: We determined the prevalence of MS and its correlation with psoriasis duration, severity, and sleep quality in psoriasis patients.
 Methods: A total of 112 subjects with chronic plaque psoriasis were studied. Demographics, MS parameters, disease duration, severity, and sleep quality were examined. The Psoriasis Area and Severity Index (PASI)and the Pittsburgh Sleep Quality Index (PSQI) were used to assess psoriasis severity and sleep quality, respectively. Presence of MS and its correlations with psoriasis duration, severity and sleep quality were investigated.
 Results: Of 112 patients, 76 (67.8%) were diagnosed with MS. Of all patients, 74.1% had a high PASI, and 84.8% had a high PSQI. The mean values of psoriasis duration, body mass index, waist circumference, fasting glucose, HOMA-IR, triglyceride levels, blood pressure, PSQI, sleep latency, and daytime sleep dysfunction were significantly higher in the MS group than non-MS group, whereas the mean HDL level was lower. The prevalences of MS, high fasting glucose, and low HDL were significantly higher among female, but not male, patients with severe psoriasis (PASI >10) than those without severe psoriasis. Disease duration, high body mass index, waist circumference, blood pressure, fasting glucose, HOMA-IR, triglyceride levels, low HDL, and poor sleep quality were significantly correlated with the presence of MS. However, only waist circumference, fasting glucose, blood pressure, and low HDL were predictive of the development of MS.
 Conclusions: MS is common among psoriasis patients, and especially in females with advanced psoriasis, high fasting glucose, and low HDL levels. Besides diagnostic criteria of MS, a long duration of psoriasis, poor sleep quality and high-HOMA-IR correlate with the development of MS. High fasting glucose and low HDL levels may facilitate MS development in association with psoriasis severity in females.
 

Association of female sex with increased risk of sleep disturbance in adult patients with moderate to severe psoriasis: a Chinese cross-sectional study

“…The results endorse and extend the findings of prior research showing a high prevalence of SD in patients with psoriasis. Recently, Tas and Kabeloglu 11 and Sahin et al . 12 separately found that the percentage of SD (PSQI score of >6) was 84.8% and 59.0%, which was higher than the 47.9% observed in the present study.…”

“…[7][8] Limited research has shown that psoriatic arthritis, the Psoriasis Area and Severity Index (PASI), depression, age, female sex, and the duration of psoriasis are associated with sleep in patients with psoriasis. [9][10][11][12][13] However, no study has examined the prevalence of SD and the factors affecting SD in Chinese patients with psoriasis.…”

Analysis of clinical features of patients with psoriasis and metabolic syndrome in Xinjiang

“…Different conclusions have been reached about the age, age at onset, and disease course of patients with psoriasis complicated by MS. Studies have shown that patients with MS are older, have an older age at onset, and have a longer disease course than patients without MS. 22 However, Chularojanamontri et al . 23 and Salunke et al .…”

Potential effects of shift work on skin autoimmune diseases

“…So far, studies on lifestyle interventions that affect sleep and investigate respective effects on disease activity are lacking ( 299 ). Impairment of sleep in patients with psoriasis, psoriatic arthritis and axial SpA increases the risk for psychiatric diseases, which themselves might impair sleep, resulting in a vicious circle ( 300 – 302 ). Moreover, patients with psoriasis and sleep disturbances have a higher risk of stroke and ischemic heart disease compared to psoriatic patients without sleep disturbances ( 303 ).…”