Prevalence of metabolic syndrome and factor analysis of cardiovascular risk clustering among adolescents in Ho Chi Minh City, Vietnam

Tang, Hong; Trang, Nguyen H.H.D.; Dibley, Michael J.

doi:10.1016/j.ypmed.2012.09.002

Cited by 18 publications

(13 citation statements)

References 21 publications

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“…Similar factor analyses conducted in studies with adults found between 2 and 3 representative factors (reviewed by Meigs) [26], which were generally characterized as metabolic, obesity, and blood pressure factors. In our study, the variables that characterized the metabolic factor were stratified into 3 different components: cholesterol/LDL, glucose metabolism, and HDL/TG, a result similar to those of other studies of adolescents [12,27]. …”

Section: Discussionsupporting

confidence: 68%

Clustered Cardiovascular Risk Factors Are Associated with Inflammatory Markers in Adolescents

Silva

Cândido

Pala³

et al. 2017

Ann Nutr Metab

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Background: Clusters of cardiovascular risk (CVR) factors are associated with an increased risk of developing cardiovascular diseases (CVDs). This cross-sectional study assessed the associations between classic CVR factor clusters and inflammatory markers in Brazilian adolescents. Methods: Measurements included anthropometric, clinical and biochemical parameters and selected inflammatory markers in 487 adolescents (236 boys/251 girls; 12.06 ± 1.41 years). Results: After stratifying the population by gender and adjusting for potential confounding variables, principal component analysis was performed and it produced 5 independent components in both genders: adiposity, glucose metabolism, blood pressure, high-density lipoprotein (HDL)/triacylglycerols (TG), and cholesterol/low-density lipoprotein. Glucose metabolism was inversely associated with interleukin-1β (IL-1β) in both genders (r = -0.026; r = -0.021); blood pressure was inversely associated with tumor necrosis factor alpha (TNF-α) in girls (r = -0.046); HDL/TG was positively associated with interleukin-6 in girls (r = 0.012), with IL-1β (r = 0.010) TNF-α (r = 0.045) in boys, and inversely associated with adiponectin in both genders (r = -0.015; r = -0.013). Conclusion: The results suggest that lipid metabolism alterations, as potential early events in the development of CVDs, have a strong link to the inflammatory process, in contrast to other clusters of risk factors.

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Section: Discussionsupporting

confidence: 68%

Clustered Cardiovascular Risk Factors Are Associated with Inflammatory Markers in Adolescents

Silva

Cândido

Pala³

et al. 2017

Ann Nutr Metab

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“…Once more, the clustering phenotype involving these three factors (obesity, dyslipidemia, and high blood pressure) was observed, as well as in the study by Hong and cols. (6). Similarly, we observed higher-than-expected prevalence for the phenotype involving excess weight, central obesity, dyslipidemia, and high blood pressure, which points out to a non-causal coexistence of these risk factors, as suggested by previous studies (6,7).…”

Section: Discussionsupporting

confidence: 89%

“…Previous studies demonstrated that clustering of cardiometabolic risk factors may occur in children, as well as in adolescents (6,7,9). It is important to emphasize the association between excess weight and the presence of clusters of cardiometabolic risk factors.…”

Section: Resultsmentioning

confidence: 97%

“…Although isolated risk factors have a specific impact on health, they are more frequently clustered in individuals (5). The clustering pattern of these risk factors have been investigated, including in adolescents (6)(7)(8)(9)(10), and this kind of analysis may subsidize the identification of risk factor clustering phenotypes in given populations (5,11), making clinical management easier by the use of specific preventive or therapeutic approaches.…”

Section: Introductionmentioning

confidence: 99%

“…Although the last decades showed an increase in the number of studies on the prevalence of cardiometabolic risk factors (6)(7)(8)(9)(10), little is known about the simultaneous occurrence of these factors, or about their clustering pattern, especially in females. Therefore, the investigation of these aspects in female adolescents, specially in low-income populations that are seek attention at the Sistema Único de Saúde (SUS), may contribute to spe-cific preventive and/or therapeutic strategies.…”

Section: Introductionmentioning

confidence: 99%

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Clustering of risk factors for cardiometabolic diseases in low-income, female adolescents

Melo

Azevedo

Silva

et al. 2016

Arch. Endocrinol. Metab.

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Objective: To assess the prevalence and clustering patterns of cardiometabolic risk factors among low-income, female adolescents. Materials and methods: Cross-sectional study involving 196 students of public schools (11-19 years old). The following risk factors were considered in the analysis: excess weight, central obesity, dyslipidemia, high blood pressure, and high fasting glucose. The ratio between observed and expected prevalence and its confidence interval were used to identify clustering of risk factors that exceeded expected prevalence in the population. Results: The most prevalent risk factors were dyslipidemia (70.9%), and central obesity (39.8%), followed by excess weight (29.6%), and high blood pressure (12.8%). A total of 42.9% of adolescents had two or more risk factors, and 24% had three or more. Excess weight, central obesity, and dyslipidemia were common risk factors in the clustering patterns that showed higher-than-expected prevalence. Conclusions: Clustering of risk factors (≥ two factors) among the adolescents showed considerable prevalence, and there was a non-casual coexistence of excess weight, central obesity, and dyslipidemia (mainly low HDL-cholesterol). Arch Endocrinol Metab. 2016;60(3):205-10

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Association of serum lead and mercury level with cardiometabolic risk factors and liver enzymes in a nationally representative sample of adolescents: the CASPIAN-III study

Poursafa

Ataee

Motlagh

et al. 2014

Environ Sci Pollut Res

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This study aims to determine the difference of serum Pb and Hg levels in adolescents with or without metabolic syndrome (MetS) and the association of serum levels of these heavy metals with cardiometabolic risk factors and liver enzymes in Iranian adolescents. The study population consisted of 320 adolescents (160 with MetS and 160 healthy controls). The relationship between serum heavy metals and cardiometabolic risk factors was assessed by linear regression. The odds ratios (OR) of having metabolic syndrome across Pb and Hg quartiles were determined by multiple logistic regression analysis. The mean (SD) of Pb and Hg concentrations were higher in adolescents with MetS than in those without it (0.83 (0.27) and 0.17 (0.01) vs. 0.65 (0.15) and 0.10 (0.08) μg/L, P = 0.01 and 0.0001, respectively). Increase in serum Pb and Hg was associated with increase in some cardiometabolic risk factors. Among boys and girls, diastolic blood pressure (DBP), fasting blood glucose, total cholesterol (TC), triglycerides (TG), and alanine aminotransaminase increased significantly across quartiles of serum Pb. Among girls, SBP, DBP, TC, and TG had a significant increase across Hg quartiles. The corresponding figure among boys was significant for SBP, DBP, and TG. Higher quartiles of Pb increased the risk of having MetS (OR 95 % CI 3.10, 2.25-4.27), the corresponding figure was 2.03, 1.75-3.16, across Hg quartiles. Our study showed significant associations between serum Pb and Hg levels with cardiometabolic risk factors in adolescents. In future surveys, the role of potential confounders should be considered more extensively. The clinical significance of these findings needs to be confirmed in longitudinal studies. By considering the origins of chronic diseases from early life, controlling environmental pollutants should be considered as a health priority for primordial or primary prevention of noncommunicable diseases.

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Prevalence of metabolic syndrome and factor analysis of cardiovascular risk clustering among adolescents in Ho Chi Minh City, Vietnam

Cited by 18 publications

References 21 publications

Clustered Cardiovascular Risk Factors Are Associated with Inflammatory Markers in Adolescents

Clustered Cardiovascular Risk Factors Are Associated with Inflammatory Markers in Adolescents

Clustering of risk factors for cardiometabolic diseases in low-income, female adolescents

Association of serum lead and mercury level with cardiometabolic risk factors and liver enzymes in a nationally representative sample of adolescents: the CASPIAN-III study

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