Prevalence of metabolic syndrome in patients with premature coronary artery disease proven by coronary angiogram

Sundaramoorthy, Varun; Mambatta, Anith Kumar; Chidambaram, Yoganathan; Gopalan, Rajendiran; Menon, Sujaya

doi:10.18203/2320-6012.ijrms20174963

Cited by 3 publications

(2 citation statements)

References 15 publications

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“…To the best of our knowledge, this meta‐analysis is the first comparing risk factors of PCAD in patients and healthy age‐ and sex‐matched individuals in Iran. The aforementioned risk factors are also highly relevant to the metabolic syndrome, a CAD determinant, but only few studies have presented its association with CAD in the young in Iran, as well as elsewhere in the world . In a recent study, we compared PCAD risk factors with late‐onset CAD ones; it was found that smoking and family history of CAD were more common in PCAD patients compared to older CAD patients in Iran, while diabetes mellitus and hypertension were less prevalent .…”

Section: Discussionmentioning

confidence: 99%

Risk factors of premature coronary artery disease in Iran: A systematic review and meta‐analysis

Poorzand

Tsarouhas

Hozhabrossadati

et al. 2019

Eur J Clin Investigation

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Background The aim of this study was to determine the mean age at which coronary artery disease (CAD) hase decreased in recent years in Iran. This systematic review and meta‐analysis compares the prevalence of different risk factors of premature CAD (PCAD) in patients vs healthy individuals. Methods Medline, Web of Science, Embase and Scientific Information Database were searched for studies about PCAD risk factors in Iran until 28 October 2017. Observational studies of Iranians, comparing risk factors between patients with PCAD and age‐ and sex‐matched healthy subjects, were included. Fixed‐effects and random‐effects model were used for pooling data. Odds ratio (OR) with 95% CI and mean difference were used for effect size estimation among studies. Results Twelve studies were eligible for meta‐analysis. Diabetes mellitus (OR: 2.4, 95% CI: 1.9‐3.03; P = 0.0001, I2 = 25.5%; P = 0.2), family history of CAD (OR: 2.09, 95% CI: 1.22‐3.6; P = 0.007, I2 = 86%; P = 0.0001), dyslipidaemia (OR: 2.05, 95% CI: 1.15‐3.64; P = 0.01, I2 = 54%; P = 0.08), smoking (OR: 1.65, 95% CI: 1.11‐2.46; P = 0.01, I2 = 77.2%; P = 0.000) and hypertension (OR: 1.35, 95% CI: 1.21 to‐1.50; P < 0.001, I2 = 31%, P = 0.1) associated with PCAD. Sensitivity analysis demonstrated that patients with PCAD had significantly lower levels of high‐density lipoprotein (HDL) cholesterol and significantly higher levels of triglycerides compared to healthy subjects (MD: −2.56, 95% CI: −3.54 to −1.58, P < 0.001, I2 = 42%, P = 0.01 and MD: 21.17, 95% CI: 14.73‐27.62, P < 0.001, I2 = 80.12%, P < 0.001, respectively). It should be noted that although high levels of heterogeneity in LDL and HDL values among the studies were observed, when dyslipidaemia was studied as a binary variable, no significant heterogeneity among studies was observed. Conclusion Diabetes mellitus, family history of CAD, dyslipidaemia, smoking, and hypertension were significantly and positively associated with CAD in young adults compared to healthy age‐ and sex‐matched population in Iran.

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Section: Discussionmentioning

confidence: 99%

Risk factors of premature coronary artery disease in Iran: A systematic review and meta‐analysis

Poorzand

Tsarouhas

Hozhabrossadati

et al. 2019

Eur J Clin Investigation

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“…Few studies have reported MetS and documented its association with young CAD patients. 7 Comprehending the consequences of MetS on CAD is significant for planning public health policy towards its prevention and management. There are limited data available on the prevalence of MetS in Indian population because of varied extent of urbanization, lifestyle patterns, and socioeconomic/ cultural factors.…”

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confidence: 99%

Prevalence of metabolic syndrome and its different components in patients with acute coronary syndrome

Jain

2019

Int J Adv Med

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Background: Several components of the Metabolic Syndrome (MetS) are risk factor for cardiovascular diseases. So, this study was conducted to evaluate the prevalence of MetS and its components in patients with CAD.Methods: Author included all patients admitted with Acute Coronary Syndrome (ACS), who had CAD confirmed by coronary angiography. They were divided into two groups according to presence or absence of MetS based on International Diabetes Federation criteria. The prevalence of MetS and its individual components was estimated.Results: It was observed that there is a high prevalence of MetS (66%) in patients admitted with ACS. Metabolic syndrome is more prevalent in female patients (82.4%) than in male patients (57.6%) with ACS. Hypertension is the most prevalent (87.9) component of MetS. Diabetes Mellitus (DM) is the 2nd most prevalent (83.3%) component of MetS. About 65.2% patients with MetS had abnormally raised triglyceride levels and 32(48.5%) had abnormally low HDL-cholesterol level. Among the MetS 38(57.6%) had abnormal waist circumference. Among the study group, the most common triad of MetS components was DM + HTN + abnormal TG. There is significant association between MetS and microalbuminuria, with incidence of 22(33.3%) in this study. Similarly, a significant association between DM and microalbuminuria, 23(33.8%) was observed.Conclusions: This study confirms a very high prevalence of MetS in Indian patients with CAD. The prevalence of the risk factors was higher in CAD patients with MetS.

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Prevalence of Metabolic Syndrome and its Clinical and Angiographic Profile in Patients with Naive Acute Coronary Syndrome

Kumar

Surhonne

Reddy

et al. 2022

Journal of Indian College of Cardiology

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Objective: The objective of the study is to evaluate the prevalence of metabolic syndrome (MS) and its clinical and angiographic profile in patients with naive acute coronary syndrome (ACS). Furthermore, this study tried to evaluate the severity of coronary artery disease in patients with and without MS. Methods: This was a single-center, cross-sectional study which prospectively enrolled 500 patients with naive ACS during the period from January 2017 to December 2018 at a tertiary care center in India. They were divided into two groups according to the presence and absence of MS based on revised NCEP ATP III guidelines. The ACS was defined based on the Joint Committee of the American College of Cardiology. After clinical evaluation and investigations, the prevalence of MS in ACS patients was calculated. Results: Prevalence of MS in this study was 46.2% and was more frequent in males (81%) compared to females (19%). Maximum number of patients with MS were between the age group of 40–59 years (55%). Prevalence of diabetes (56.7%), hypertension (58.0%), and smoking (45.88%) were significantly higher in patients with MS (P < 0.001). Most prevalent components of MS were low high-density lipoprotein (HDL) levels, increased blood pressure, fasting blood sugar, and triglyceride levels (P < 0.001). Conclusion: Prevalence of MS was high in patients with ACS and was more often after the age of 40 years and most commonly seen in males. Low HDL levels, increased blood pressure, and blood sugar were most prevalent components in the criteria for MS. Patients with MS tend to have more complex coronary lesions.

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Prevalence of metabolic syndrome in patients with premature coronary artery disease proven by coronary angiogram

Cited by 3 publications

References 15 publications

Risk factors of premature coronary artery disease in Iran: A systematic review and meta‐analysis

Risk factors of premature coronary artery disease in Iran: A systematic review and meta‐analysis

Prevalence of metabolic syndrome and its different components in patients with acute coronary syndrome

Prevalence of Metabolic Syndrome and its Clinical and Angiographic Profile in Patients with Naive Acute Coronary Syndrome

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