Prevalence of Metabolic Syndrome in Patients with Psoriasis

Abstract

Background. Psoriasis is a chronic inflammatory skin disorder in which proinflammatory cytokines including IL-6 and TNF-α increase both locally and systematically. It is thought that chronic inflammation results in metabolic diseases and proinflammatory cytokines give rise to the development of atherogenesis, peripheral insulin resistance, hypertension, and type 2 diabetes. Our aim was to investigate the prevalence of metabolic syndrome in patients with psoriasis vulgaris. Methods. Study consisted of 115 plaque-type psoriasis patients and 140 healthy individuals. Data including body weight, height, waist circumference, body-mass index, and arterial blood pressure were collected. Fasting blood glucose, triglyceride, and HDL levels were determined. International Diabetes Federation Criteria for Metabolic Syndrome and Insulin Resistance were used for evaluating patients with metabolic syndrome and diabetes. Results. Compared to the control group, metabolic syndrome, diabetes mellitus, and hypertension were found to be higher in psoriasis patients. Metabolic syndrome was increased by 3-folds in psoriasis patients and was more prevalent in women than in men. It was determined that the prevalence of metabolic syndrome was higher in psoriasis patients after the age of 40. Metabolic syndrome was not related to smoking, severity of psoriasis, and duration of disease. Conclusions. Our findings suggest that psoriasis preconditions occurrence of a group of diseases such as diabetes mellitus, hypertension, and metabolic syndrome. For this reason, patients with psoriasis should be treated early and they should be followed with respect to metabolic diseases.

Metabolic syndrome in patients with chronic plaque psoriatic disease: a case-control study from western Uttar Pradesh, India

“…This observation is in agreement with many studies, which have shown a significantly higher prevalence of metabolic syndrome among psoriasis patients compared to controls. 6,10,14 However, this finding may not be comparable with the investigations done in different geographical milieu viz. Bangalore, Kashmir and Mumbai, as they did not use the Asian modification for waist circumference.…”

“…10,14 But this is in contrast to the study by Zindancı I et al from Turkey. 6 Regarding distribution pattern of psoriatic cases, in our study out total 50 cases, 39 had psoriasis vulgaris, 6 had psoriatic erythroderma and 4 patients had palmoplantar psoriasis and one patient had acute generalized pustular psoriasis. Of the 39 cases with psoriasis vulgaris, psoriasis was stable in 35 patients and unstable in 4 patients.…”

“…6 Various studies on psoriasis and metabolic syndrome have shown a large variation in their results. Apart from this, an increasing frequency is imposing a substantial burden on the overall health of psoriasis patients that needs to be appropriately foreseen and addressed.…”

Prevalence of metabolic syndrome in psoriasis vulgaris: a cross sectional study from a tertiary care hospital of South-East Rajasthan

“…This is in accordance with the study by Lakshmi et al and Zindancı et al but in contrast to study by Gisondi et al in which prevalence of MetS was independent of gender. 10,14,7 The possible explanation for higher prevalence of metabolic syndrome in females in our study could be that most of the women in our region are housewives having relatively sedentary lifestyle and limited outdoor activities.…”

Body mass index and psoriasis area and severity index relation in Turkish psoriasis population

“…Obezite ve psoriasis ilişkisi ile ilgili çok sayıda çalışma yapılmıştır. Bazı çalışmalarda obezite, psoriasis şiddeti ile ilişkili bulunurken bazılarında ilişkisiz olarak bulunmuştur [10][11][12][13][14][15][16][17] . Sunduğumuz çalışmada obezite ve psoriasis şiddeti zayıf ilişkili olarak tespit edilmiştir.…”