Prevalence of Metabolic Syndrome in Treatment Naïve Rheumatoid Arthritis and Correlation With Disease Parameters

Pandey, Purneshwar Kumar

doi:10.5606/archrheumatol.2017.5949

Cited by 13 publications

(10 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This association has been previously reported. 26 We didn`t find any significant association between age, duration of disease, disease activity score with MS in RA as has been reported by previous studies. 15,19,26 However, disease activity score has not been associated with MS in RA in many studies.…”

Section: Discussionmentioning

confidence: 39%

“…26 We didn`t find any significant association between age, duration of disease, disease activity score with MS in RA as has been reported by previous studies. 15,19,26 However, disease activity score has not been associated with MS in RA in many studies. 16,27 This can be explained by the fact that DAS, CRP is a single point measure of disease activity and it can vary with time depending upon the dose of quick relief medications like NSAID`s and steroids.…”

Section: Discussionmentioning

confidence: 39%

“…In India, also higher prevalence of MS has been reported from Silchar (39.28% in RA and 20 % in controls) and Chandigarh (31.57%in RA and 14.9%). 19,[21][22][23][24][25][26][27] When exploring the clinical and biochemical parameters in present study, RA patients had lower HDL, higher systolic BP and higher diastolic BP compared with healthy controls, a difference that was statistically significant. These results are in accordance with observations made by Rostom et al and Pandey et al 16,26 We did not find any significant correlation of body mass index (BMI), waist circumference and sugar between two groups.…”

Section: Discussionmentioning

confidence: 90%

See 2 more Smart Citations

Prevalence and predictors of metabolic syndrome in rheumatoid arthritis

et al. 2017

View full text Add to dashboard Cite

Background: Rheumatoid arthritis (RA) is associated with increased cardiovascular morbidity and mortality secondary to accelerated atherosclerosis. There is a strong association of metabolic syndrome (MS) with atherosclerosis. The objective of this study was to assess the prevalence of MS in RA and to identify the predictors of MS in RA. Methods: The study included 100 patients of RA (83 females,17 males; median age 42.5(17) years diagnosed according to 2010 American College of Rheumatology-European League Against Rheumatism classification criteria who were on treatment and 110 age and sex-matched apparently healthy controls (26 males, 84 females; median age 45 (20) years). The frequency of MS was assessed using joint consensus 2009 criteria. Patients were also assessed in terms of disease activity, using disease activity score 28 CRP. Logistic regression was used to identify predictors of MS in RA.Results: Metabolic syndrome was found in 45% of RA group and 22.7% of control group according to joint consensus 2009 criteria (p<0.005). RA group was significantly more likely to have low high-density lipoprotein (65%), elevated blood pressure (60%) levels and abnormal sugar (28%). In RA group, CRP (odds ratio: 1.101, confidence interval: 1.032-1.174 (p=0.004) {adjusted for age, DAS 28 score & Anti-CCP} remained independent predictor for presence of MS in RA.Conclusions: The frequency of MS was higher in RA group compared to control group. High CRP remained independent predictor associated with presence of MS. There was no association of high disease activity with MS in our RA patients. These findings suggest that the treating physician should screen RA patients early for presence of MS.

show abstract

Section: Discussionmentioning

confidence: 39%

Section: Discussionmentioning

confidence: 39%

Section: Discussionmentioning

confidence: 90%

See 1 more Smart Citation

Prevalence and predictors of metabolic syndrome in rheumatoid arthritis

et al. 2017

View full text Add to dashboard Cite

show abstract

“…The potential risk factors of MetS were analyzed by multivariate logistic regression model. All covariates in the present study were chosen referring to the previous studies 20‐24 …”

Section: Methodsmentioning

confidence: 99%

Prevalence of metabolic syndrome in patients with rheumatoid arthritis in eastern China—A hospital based study

et al. 2021

View full text Add to dashboard Cite

Objective The purpose of this hospital clinic based study was to evaluate the potential risk factors associated with the prevalence of MetS in RA population. Methods From January 2015 to October 2018, 717 patients with RA and 717 healthy controls who were treated or performed physical examination in Tianjin First Central Hospital were enrolled in this study. The basic disease diagnoses were recorded. A questionnaire was performed on all participants to assess the demographic details of the RA cohort. Moreover, laboratory indicators related to glucose and lipid metabolism in patients with RA were also detected. The potential risk factors for MetS were also analyzed. Results The prevalence of MetS were 31.2% and 34.2% in case and control groups, respectively (P = .22). There were lower levels of HDL‐C, obesity, TG, LDL‐C and TC in case group than control group (all P < .05). The hypertension levels in healthy controls was decreased in compared with patients with RA (P < .05). Nevertheless, in patients with RA, complement 3 (OR: 1.02; 95% CI: 1.01‐1.03, P = .007) and less glucocorticoids use (OR: 0.63, 95% CI: 0.39‐0.99, P = .046) were associated with MetS. Conclusion The prevalence of MetS was not associated with RA. Complement 3 may be associated with the higher prevalence of MetS in patients with RA. Glucocorticoids treatment may be associated with MetS.

show abstract

“…Previous studies have documented distinct genetic susceptibility loci and suggest the presence of a considerable burden of clinical sequelae such as renal dysfunction and osteoporosis in RA patients from northeast India. [ 12 , 13 , 14 ] However, there is a paucity of studies investigating CVD risk or the magnitude of MetS and its determinants in RA patients from the region. With this background, the current study aimed to study the magnitude of MetS and its determinants in RA patients from northeast India.…”

Section: Introductionmentioning

confidence: 99%

Metabolic syndrome and atherogenic indices in rheumatoid arthritis and their relationship with disease activity: A hospital-based study from northeast India

Bhattacharya

Barman

Jamil

et al. 2020

Journal of Translational Internal Medicine

View full text Add to dashboard Cite

Background and ObjectiveMetabolic syndrome (MetS), a constellation of metabolic abnormalities including hypertension, obesity, glucose intolerance, and dyslipidemia, is highly prevalent in patients with rheumatoid arthritis (RA). Our aim was to assess the magnitude of MetS and its determinants in RA patients and to evaluate different atherogenic indices that are reflective of the risk for future cardiovascular disease.Patients and MethodsThe study was conducted on 104 RA patients and 103 age- and sex-matched healthy controls. The frequency of MetS was assessed using the guidelines recommended for Asian Indians.ResultsA total of 104 RA patients participated with majority being females (85.6%), with a mean age of 43.82 ± 13.32 years. The frequency of MetS in patients with RA (36.5%) was significantly higher than in controls (15.5%). The atherogenic indices were found to be significantly higher in RA patients than controls (P < 0.01). On logistic regression, disease activity score (DAS28) scale for 28 joints and disease duration remained significant independent predictors of the presence of MetS in RA patients (P < 0.01 and 0.05, respectively).ConclusionsRA is a kind of chronic disease of long course, and MetS and atherogenic indices are often concomitant in these patients. The study showed that the frequency of MetS was higher in patients with RA than in controls, and that DAS28 and disease duration remained significant independent predictors of the presence of MetS in RA patients.

show abstract

Prevalence of Metabolic Syndrome in Treatment Naïve Rheumatoid Arthritis and Correlation With Disease Parameters

Cited by 13 publications

References 25 publications

Prevalence and predictors of metabolic syndrome in rheumatoid arthritis

Prevalence and predictors of metabolic syndrome in rheumatoid arthritis

Prevalence of metabolic syndrome in patients with rheumatoid arthritis in eastern China—A hospital based study

Metabolic syndrome and atherogenic indices in rheumatoid arthritis and their relationship with disease activity: A hospital-based study from northeast India

Contact Info

Product

Resources

About