Prevalence of Metabolic Syndrome in Pakistan

Basit, Abdul; Shera, A. Samad

doi:10.1089/met.2008.0005

Cited by 74 publications

(59 citation statements)

References 17 publications

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“…The association of age with the disease is highly significant as the P value is < 0.01. The mean value of age in the cases is 47.66 ± 1.2 and this is congruent with a previous local study in which the mean age was 45 ± 15 (22). There is no significant difference in the mean weight of the cases and controls (p-value 0.09).…”

Section: Discussionsupporting

confidence: 90%

The Pro115Gln Missense Mutation of Peroxisome Proliferator Activated Receptor γ (PPARγ) Gene in Diabetes in the Pakistani Population

Sarwar

Naveed²

2016

Avicenna J Clin Microbiol Infect

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Background: Diabetes is an alarmingly increasing public health concern. According to a World Health Organization (WHO) report, diabetes is highly prevalent in almost all regions of Pakistan, with an overall prevalence of 22.04% in urban and 17.15% in rural areas. In addition to lifestyle factors, genetics plays an important part in the progression to diabetes, of which peroxisome proliferator activated receptors (PPARs), a super-family of transcriptional regulators, are considered to be very critical. Objectives:The aim of the current study was to investigate the prevalence of a missense mutation Pro115Gln in the PPARγ; gene in Pakistan and search for its effects on certain serum biochemical parameters. Materials and Methods: A total of 1015 subjects (490 diabetics and 525 healthy controls) were genotyped by PCR-RFLP and serum profiling was performed. Results: We could not detect the mutation in the study subjects, but the anthropometric and biochemical parameters were significantly different between the cases and controls. Conclusions: In conclusion, as this mutation is present in a highly conserved region and any change in this region would adversely affect the protein structure and function, so the prevalence of this mutation is very low.

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Section: Discussionsupporting

confidence: 90%

The Pro115Gln Missense Mutation of Peroxisome Proliferator Activated Receptor γ (PPARγ) Gene in Diabetes in the Pakistani Population

Sarwar

Naveed²

2016

Avicenna J Clin Microbiol Infect

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“…The same type of finding was observed by the researcher of our neighboring countries. 5,12 -This similarity might be due to sharing similar type of lifestyle and socioeconomic status. The study on the population of native Alaska showed the prevalence of metabolic syndrome to be 23.70%).…”

Section: Resultsmentioning

confidence: 99%

Prevalence of Metabolic Syndrome in Ischemic Heart Disease Patients

Sultana

Kabir²,

Hossain

et al. 2015

J Dhaka Med Coll

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“…In our study, low HDL-C level (83.23%) was the most common abnormality causing dyslipidemia. Basit and Shera reported low HDL-C levels in 68-81% of the Pakistani population [29]. The predominance of atherogenic dyslipidemia, glucose intolerance, thrombotic tendency, subclinical inflammation, and endothelial dysfunction among Asians in comparison to Caucasians has been reported [24].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of the metabolic syndrome in rural India—a disparity in definitions

Kempegowda

Marcus²,

P³

et al. 2011

Int J Diabetes Dev Ctries

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Although the metabolic syndrome is a known predictor of coronary heart disease and type-2 diabetes mellitus, it has no agreed definition. The concordance of its various definitions has been studied for a limited number of populations and there are few studies on the rural populations in India. The present study was done to determine the prevalence of metabolic syndrome in a rural population of South India and to evaluate the concordance of the modified National Cholesterol Education Programme-Adult Treatment Panel III definition and International Diabetes Federation definition for the diagnosis of Metabolic Syndrome. Anthropometric and biochemical parameters (fasting blood glucose and lipid profile) and blood pressure were measured using standard procedures. The prevalence of metabolic syndrome was calculated using the two sets of criteria and compared for their concordance. Descriptive statistics was used to analyze age and risk factors of metabolic syndrome. The chi-square test was applied to compare the prevalence of metabolic syndrome obtained from the two criteria (significant if p<0.05). An inter-rater reliability analysis using the kappa statistic was performed to determine consistency between the two sets of criteria in diagnosing the metabolic syndrome. The modified National Cholesterol Education Programme-Adult Treatment Panel III definition and International Diabetes Federation definition for metabolic syndrome identified overall age-adjusted prevalence of 17.8% and 20.5% respectively, which were not significantly different. Kappa statistics revealed only moderate agreement of 0.44 between the two sets of criteria. The impact of economic development and preponderance of genetic factors is increasing the prevalence of metabolic syndrome in rural India. It is important to determine which definition of the metabolic syndrome best predicts coronary heart disease and type 2 diabetes in this population in order to formulate effective public health policy.

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Prevalence of Metabolic Syndrome in Pakistan

Cited by 74 publications

References 17 publications

The Pro115Gln Missense Mutation of Peroxisome Proliferator Activated Receptor γ (PPARγ) Gene in Diabetes in the Pakistani Population

The Pro115Gln Missense Mutation of Peroxisome Proliferator Activated Receptor γ (PPARγ) Gene in Diabetes in the Pakistani Population

Prevalence of Metabolic Syndrome in Ischemic Heart Disease Patients

Prevalence of the metabolic syndrome in rural India—a disparity in definitions

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