Prevalence of methicillin-resistant Staphylococcus aureus and Acinetobacter baumannii in a long-term acute care facility

Furuno, Jon P.; Hebden, Joan N.; Standiford, Harold C.; Perencevich, Eli N.; Miller, Ram R.; Moore, Anita C.; Strauss, Sandra M.; Harris, Anthony D.

doi:10.1016/j.ajic.2008.01.003

Cited by 83 publications

(72 citation statements)

References 12 publications

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“…The article demonstrated that Acinetobacter baumannii is widespread including hospitals, long-term acute-care and nursing homes, and that the transfer of multidrugresistant strains among health care facilities is bidirectional. These data confirm previous report (Gould CV & Al, 2006;Saeed S & Al, 2006;Stephens C & Al, 2007;Furuno JP & Al, 2008) …”

Section: Others Organismssupporting

confidence: 83%

Antibiotic Resistance in Nursing Homes

Ricci¹,

Barrionuevo²,

Cosso³

et al. 2012

Antibiotic Resistant Bacteria - A Continuous Challenge in the New Millennium

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Section: Others Organismssupporting

confidence: 83%

Antibiotic Resistance in Nursing Homes

Ricci¹,

Barrionuevo²,

Cosso³

et al. 2012

Antibiotic Resistant Bacteria - A Continuous Challenge in the New Millennium

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“…Traditionally, infections caused by Acinetobacter species were restricted to the intensive care unit (ICU) setting and to military personnel who have experienced combat-related injuries (6). More recently, these pathogens have spread to other locations in the hospital and to nonhospital populations and health care settings (1,6,7). Infections caused by A. baumannii are associated with devastating outcomes in terms of morbidity and mortality and contribute to high hospital costs.…”

mentioning

confidence: 99%

“…A cinetobacter, a Gram-negative coccobacillus, has become a frequent pathogen in hospitals and other health care settings (1,2). Found naturally in soil, these bacteria remain stable even under extreme conditions of temperature, humidity, and pH and in the presence of commonly used detergents, such as highly concentrated alcohol preparations, and other antiseptics that normally inhibit the growth of other bacteria (3).…”

mentioning

confidence: 99%

Epidemiology of Bloodstream Infections Caused by Acinetobacter baumannii and Impact of Drug Resistance to both Carbapenems and Ampicillin-Sulbactam on Clinical Outcomes

Chopra

Marchaim

Awali

et al. 2013

Antimicrob Agents Chemother

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In-hospital mortality rates for BSI caused by CASR A. baumannii were significantly higher than those for non-CASR A. baumannii-induced BSI (43% versus 20%; OR ‫؍‬ 3.0, 95% CI ‫؍‬ 1.60 to 5.23, P value < 0.001). However, after adjusting for potential confounders, the association between BSI caused by CASR A. baumannii and increased risk of in-hospital mortality was not significant (OR ‫؍‬ 1.15, 95% CI ‫؍‬ 0.51 to 2.63, P value ‫؍‬ 0.74). This study demonstrated that CASR A. baumannii had a distinct epidemiology compared to more susceptible A. baumannii strains; however, clinical outcomes were similar for the two groups. Admission with a rapidly fatal condition was an independent predictor for both CASR A. baumannii and in-hospital mortality.

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“…ethicillin-resistant Staphylococcus aureus (MRSA) prevalence in nursing homes often exceeds that in acute care settings, including intensive care units (2)(3)(4)39). The MRSA burden may be high because nursing home residents have multiple comorbidities, chronic wounds, frequent exposure to antibiotics, and require health care worker contact to perform activities of daily living (ADL) (2,5,6).…”

mentioning

confidence: 99%

Chlorhexidine and Mupirocin Susceptibilities of Methicillin-Resistant Staphylococcus aureus from Colonized Nursing Home Residents

McDanel

Murphy

Diekema

et al. 2013

Antimicrob Agents Chemother

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f Chlorhexidine and mupirocin are used in health care facilities to eradicate methicillin-resistant Staphylococcus aureus (MRSA) carriage. The objective of this study was to assess the frequency of chlorhexidine and mupirocin resistance in isolates from nares carriers in multiple nursing homes and to examine characteristics associated with resistance. Nasal swab samples were collected from approximately 100 new admissions and 100 current residents in 26 nursing homes in Orange County, CA, from October 2008 to May 2011. MRSA isolates were tested for susceptibility by using broth microdilution, disk diffusion, and Etest; for genetic relatedness using pulsed-field gel electrophoresis; and for qac gene carriage by PCR. Characteristics of the nursing homes and their residents were collected from the Medicare Minimum Data Set and Long-Term Care Focus. A total of 829 MRSA isolates were obtained from swabbing 3,806 residents in 26 nursing homes. All isolates had a chlorhexidine MIC of <4 g/ml. Five (0.6%) isolates harbored the qacA and/or qacB gene loci. Mupirocin resistance was identified in 101 (12%) isolates, with 78 (9%) isolates exhibiting high-level mupirocin resistance (HLMR). HLMR rates per facility ranged from 0 to 31%. None of the isolates with HLMR displayed qacA or qacB, while two isolates carried qacA and exhibited low-level mupirocin resistance. Detection of HLMR was associated with having a multidrug-resistant MRSA isolate (odds ratio [OR], 2.69; P ‫؍‬ 0.004), a history of MRSA (OR, 2.34; P < 0.001), and dependency in activities of daily living (OR, 1.25; P ‫؍‬ 0.004). In some facilities, HLMR was found in nearly one-third of MRSA isolates. These findings may have implications for the increasingly widespread practice of MRSA decolonization using intranasal mupirocin.

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Prevalence of methicillin-resistant Staphylococcus aureus and Acinetobacter baumannii in a long-term acute care facility

Abstract: Background-Patients in long-term acute care (LTAC) facilities often have many known risk factors for acquisition of antibiotic-resistant bacteria. However, the prevalence of resistance in these facilities has not been well described.

Cited by 83 publications

References 12 publications

Antibiotic Resistance in Nursing Homes

Antibiotic Resistance in Nursing Homes

Epidemiology of Bloodstream Infections Caused by Acinetobacter baumannii and Impact of Drug Resistance to both Carbapenems and Ampicillin-Sulbactam on Clinical Outcomes

Chlorhexidine and Mupirocin Susceptibilities of Methicillin-Resistant Staphylococcus aureus from Colonized Nursing Home Residents

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