Prevalence of methylenetetrahydrofolate reductase C677T and A1298C polymorphisms in Egyptian patients with type 2 diabetes mellitus

AbdRaboh, Naglaa Raafat; Badr, Soheir; Ali, Samia Taher

doi:10.1016/j.ejmhg.2012.09.002

Cited by 17 publications

(30 citation statements)

References 41 publications

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“…Similarly, previous studies have found no significant associations between lipid/glucose metabolic indexes with MTHFR 1298 genotypes among T2DM patients [24,25]. Another study also has reported that BMI, hypertension, family history, HbA1c, total cholesterol, and fasting blood glucose of the diabetic patients segregated according to the MTHFR 1298 genotypes genotypes were similar except triglyceride levels [36].…”

Section: Association Of Mthfr 1298 Genotypes Versus Clinical and Biocmentioning

confidence: 50%

“…A previous study conducted in the Tunisian population has reported that the MTHFR A1298C was significantly associated with type 2 diabetes [23]. Another study suggested that MTHFR A1298C polymorphism is a risk factor for T2DM in Egyptian population [24], while other studies did not find any association with diabetes in Taiwanese and Moroccan population [25,26].…”

Section: Mthfr A1298c Gene Polymorphism and T2dmmentioning

confidence: 94%

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Association of MTHFR A1298c Gene Variant, Dna Damage, and Total Antioxidant Status With the Risk of Type 2 Diabetes Mellitus and Its Complications

Nithya

Isabel

Angeline

et al. 2018

Asian J Pharm Clin Res

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Objectives:We have examined the association of methylenetetrahydrofolate reductase (MTHFR) gene A1298C variant, DNA damage, and total antioxidant status (TAS) in patients with type 2 diabetes mellitus (T2DM) with and without complications and in healthy controls.Methods: A total of 300 subjects including 100 patients with complications, 100 patients without complications, and 100 controls were included. TAS was assessed by ferric reducing ability of plasma assay. DNA damage was analyzed in lymphocytes using the comet assay. Polymerase chain reactionrestriction fragment length polymorphism analysis was performed to study the MTHFR A1298C gene polymorphism among the study subjects. Results:The results revealed that the MTHFR 1298 AC+CC genotypes were associated with increased risk (2 fold) for diabetes and its complications. When the effect of DNA damage was analyzed, significant differences between individuals with mutant and normal genotype among the diabetic patients (with and without complications) was observed (p≤0.001). In contrary, no significant difference was found between TAS and 1298 genotypes (AA versus AC+CC) in type 2 diabetic patients (with and without complications), p=0.338. We also found a significant difference between the genotypes of the MTHFR A1298C and DNA damage, TAS in T2DM patients (with and without complications) when compared to controls, p<0.001. Conclusions:Our findings suggest that the MTHFR A1298C gene polymorphism is considered as a risk factor for the development of diabetes and its complications among south Indians. Therefore, increased DNA damage and decreased TAS along with the occurrence of a mutant genotype in an individual with diabetes may be at an increased risk for the development of chronic complications.

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Section: Association Of Mthfr 1298 Genotypes Versus Clinical and Biocmentioning

confidence: 50%

Section: Mthfr A1298c Gene Polymorphism and T2dmmentioning

confidence: 94%

Association of MTHFR A1298c Gene Variant, Dna Damage, and Total Antioxidant Status With the Risk of Type 2 Diabetes Mellitus and Its Complications

Nithya

Isabel

Angeline

et al. 2018

Asian J Pharm Clin Res

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“…One study [24] investigated T2DM risk from both cross-sectional and longitudinal perspectives. Finally, this meta-analysis consisted of 56 cross-sectional studies [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][26][27][28][29][30][31][32][33][34][35][36][37][38][39]41,[43][44][45][48][49][50][51][52][53][55][56][57][58][59][60][63][64]…”

Section: Eligible Studiesmentioning

confidence: 99%

“…From two to 49 SNPs were analysed. Approximately half of included studies (28 studies) [8,9,[11][12][13]15,16,18,21,23,26,29,39,45,48,50,52,[54][55][56][57][58][61][62][63][64][65][66] used less than three SNPs. Twenty-three studies [5,11,15,17,19,20,22,24,27,30,33,37,40,42,46 Figure 1 shows the relationship between the ΔRA total and the crude OR in log scale for T2DM.…”

Section: Eligible Studiesmentioning

confidence: 99%

Meta‐analytic research on the relationship between cumulative risk alleles and risk of type 2 diabetes mellitus

Kodama

Fujihara

Ishiguro

et al. 2015

Diabetes Metabolism Res

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“…In contrast to the 677CC wild genotype, the 677TT homozygous and 677CT heterozygous genotypes cause a decreased level of enzymatic activity by around 70% and 40%, respectively. The distribution of this polymorphism among ethnic groups is about 54.5% [9]. The objective of this study was to evaluate whether methylene tetrahydrofolate reductase (MTHFR) C677T gene polymorphism was a risk factor for the development of diabetic nephropathy in addition to other chronic complications in type II diabetes mellitus patients.…”

Section: Introductionmentioning

confidence: 99%

Methylene Tetrahydrofolate Reductase Gene Polymorphism C677T & Risk of Type two Diabetes Mellitus in Beni-Suef Governorate

Elessawi

Demellawy

Farhan

et al. 2020

Arab Journal of Nuclear Sciences and Applications

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Methylene Tetrahydrofolate Reductase (MTHFR) is known to be a regulatory enzyme of homocysteine metabolism. In many ethnic groups point mutations in MTHFR gene are implicated in the pathogenesis of diabetic nephropathy (DN) and other complications of type II diabetes mellitus (T2DM). The aim of this study was to assess if MTHFR C677T gene polymorphism was one of the risk factors for the development of diabetic nephropathy as well as other complications in type 2 diabetes mellitus patients. The MTHFR C6777T polymorphisms were detected in 50 persons by PCR-RFLP. Subjects were divided into 2 groups; 30 patients with type II DM and 20 persons who were non-diabetic healthy controls. The presence of MTHFR 677T allele did not increase the risk of complications in T2DM patients. The presence of mutant genotypes CT and TT did not increase the risk of nephropathy or other complications in the subjects having a C677T mutation. Methylene Tetrahydrofolate Reductase (MTHFR) C677T gene mutation was neither associated with an increased risk of diabetic nephropathy nor other complications of type II diabetes mellitus.

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Prevalence of methylenetetrahydrofolate reductase C677T and A1298C polymorphisms in Egyptian patients with type 2 diabetes mellitus

Cited by 17 publications

References 41 publications

Association of MTHFR A1298c Gene Variant, Dna Damage, and Total Antioxidant Status With the Risk of Type 2 Diabetes Mellitus and Its Complications

Association of MTHFR A1298c Gene Variant, Dna Damage, and Total Antioxidant Status With the Risk of Type 2 Diabetes Mellitus and Its Complications

Meta‐analytic research on the relationship between cumulative risk alleles and risk of type 2 diabetes mellitus

Methylene Tetrahydrofolate Reductase Gene Polymorphism C677T & Risk of Type two Diabetes Mellitus in Beni-Suef Governorate

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