Prevalence of microalbuminuria among adults with Type 2 Diabetes mellitus at OOUTH, Sagamu

Abstract

Background: Diabetes mellitus is a serious global epidemic. The menace of this chronic disease is attributable to its chronic complications which threaten both the world economy and life expectancy, especially in Sub- Saharan Africa. Nephropathy is a complication of Diabetes mellitus and a leading cause of End Stage Renal Disease.
 Objectives: To determine the prevalence of microalbuminuria as well as the effects of co-morbidities on the pattern of microalbuminuria among adults with Type 2 Diabetes mellitus.
 Methods: A total of 325 adults with Diabetes mellitus and 100 controls without Diabetes mellitus were studied. The subjects with diabetes were classified into four groups ([i] diabetes only, [ii] diabetes with hypertension, [iii] diabetes with obesity and [iv] diabetes with hypertension and obesity). Urinary protein, microalbuminuria, fasting plasma glucose and Glycated Haemoglobin (HbA1c) were measured using standard methods.
 Results: The overall prevalence of microalbuminuria was 35.1% in the diabetic population compared to 8.0% in the control group. The prevalence of microalbuminuria in the various diabetic subgroups were as follows: 30.3% (diabetes only), 43.1% (diabetes with hypertension), 37.0% (diabetes with obesity) and 44.6% (diabetes with hypertension and obesity). The fasting plasma glucose and HbA1c were statistically significantly higher in the diabetic population than the control group. This indicated that there is a poor glycaemic control in the diabetic population and hence a possible cause of diabetic nephropathy.
 Conclusion: The risk of diabetic nephropathy was significant in the study population. The presence of one or more co-morbidities and poor glycaemic control increased the occurrence of diabetic nephropathy.

Prevalence of Microalbuminuria and Associated Factors Among Type 2 Diabetes Mellitus Patients in Jigjiga Town Public Hospitals, Somali Regional State, Ethiopia, 2020

“…Microalbuminuria reported in the cross-sectional studies conducted in Karachi, Pakistan with a prevalence rate of 31.56%[36],35.1% reported in Ogun State in Nigeria [37], and 37% reported in Gondar, Ethiopia [22],all of which may be due to differences in study period, sample size, measuring tools, methods used, and also de nitions of microalbuminuria where microalbuminuria was de ned by these studies as albumin to creatinine ratio ranging from 30 to 300 mg/g in a 24-hour urine collection, (ours de ned as ranging 20-199mg/l in a morning spot urine collection).were also markedly lower than the prevalence rate of this study.…”

Plasma Histone Deacetylase activities, Lipid Profile, and Glycated Haemoglobin levels as indicator of Glycemic control in Type 2 Diabetes Mellitus

“…Metabolic disorders occur when there is alteration in the normal metabolic processes resulting in abnormal biochemical reactions in the body. Diabetes mellitus (DM), as an example of metabolic disorders, is primarily a disorder of glucose metabolism with the affectation of fat and protein metabolism due to abnormal insulin secretion, deficient action of insulin on target tissues, or both [1,2]. The pathognomonic clinical features of DM are hyperglycemia-induced and resultant complications include ketoacidosis, angiopathy, neuropathy, retinopathy, nephropathy, gangrene, infection, dysfunction and failure of various organs among others [2].…”