Prevalence of Microalbuminuria and Its Association with Pulse Pressure in a Multi-Ethnic Population in Amsterdam, The Netherlands

Agyemang, Charles; Valkengoed, Irene G. M. van; Born, Bert‐Jan H. van den; Stronks, Karien

doi:10.1159/000112923

Cited by 3 publications

(2 citation statements)

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“…with at least one parent born in Surinam) and Dutch individuals, aged 35 to 60 years of age, drawn from the Amsterdam population register [6,21]. In 1975, almost half of the population of the former Dutch colony Surinam migrated to the Netherlands.…”

Section: Methodsmentioning

confidence: 99%

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Ethnic differences in the association between waist-to-height ratio and albumin-creatinine ratio: the observational SUNSET study

et al. 2012

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BackgroundEthnic differences in the association between central obesity and raised albumin-creatinine ratio (ACR) have not been investigated. Our aim was to determine whether the association between central obesity, defined by the waist-to-height ratio (WHtR), and ACR differed between subjects of Hindustani-Surinamese, African-Surinamese and Dutch origin.MethodsIn total, 334 Hindustani-Surinamese (~South Asian), 589 African-Surinamese (~African), and 493 Dutch (~European) men and women, aged 35–60 years, randomly selected from the municipal register of Amsterdam, participated in an interview and physical examination.We calculated the WHtR by dividing the waist circumference by height and the log ACR (logACR, log mg/mmol) by log-transforming the albumin concentration by the creatinine concentration in urine. The association between WHtR and logACR was studied in the total population and stratified by ethnicity. We also tested for interaction.ResultsIn the total population, a higher WHtR was associated with a higher logACR, after adjustment for sex, age, and smoking, body mass index and the presence of type 2 diabetes or hypertension. Among the Hindustani-Surinamese, the adjusted association between WHtR and logACR appeared somewhat stronger than among the other ethnic groups: for every 0.1 increase in the WHtR, the log-ACR increased by 0.522 (0.096-0.949) log mg/mmol among the Hindustani-Surinamese, by 0.334 (0.047-0.622) among the African-Surinamese and by 0.356 (−0.010-0.721) among the Dutch. However, the interaction was not statistically significant.ConclusionsWHtR was associated with a higher ACR among populations of Hindustani-Surinamese, African-Surinamese and Dutch origin. Our study seems to support global use of WHtR in relation to ACR across ethnic groups. However, although not significant, the association appeared slightly stronger among the Hindustani-Surinamese than among the other ethnic groups. If confirmed, this could have implications for use of the WHtR across ethnic groups.

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Section: Methodsmentioning

confidence: 99%

“…Ethnic minorities have a greater risk of albuminuria and a higher ACR than subjects of European origin [3-6]. …”

Section: Introductionmentioning

confidence: 99%

Ethnic differences in the association between waist-to-height ratio and albumin-creatinine ratio: the observational SUNSET study

et al. 2012

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Lower frequency of the 5/5 homozygous CNDP1 genotype in South Asian Surinamese

Mooyaart

Valkengoed

Shaw

et al. 2009

Diabetes Research and Clinical Practice

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Overview of the i-SEARCH Global Study

Böhm

Thoenes

Danchin

et al. 2008

High Blood Pressure & Cardiovascular Prevention

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Microalbuminuria (MAU) is a highly predictive, sensitive, inexpensive and easily repeatable marker of cardiovascular risk and all-cause mortality in hypertensive patients. The international, observational, practice-based study i-SEARCH (Survey for Evaluating Microalbuminuria Routinely by Cardiologists in patients with Hypertension) was designed to assess the frequency with which MAU occurred in a large outpatient population who were currently treated or newly diagnosed with hypertension and were under professional care. The primary aim of the study was to define the prevalence of MAU in hypertensive outpatients attending a cardiologist or internist (i-SEARCH A) and to compare hypertensive outpatients with or without coronary artery disease (i-SEARCH B). A secondary objective was to establish a correlation between MAU and known cardiovascular risk factors. A total of 21 050 patients from 26 countries were included in the primary analysis. Overall, this study demonstrated a very high worldwide prevalence (58.4%) of MAU in high-risk cardiovascular patients, but with a considerable variation across countries. MAU was more prevalent in patients with coronary artery disease than in those without. It was also significantly related to the presence of specific predictors, including male gender, abnormally high waist circumference, increased blood pressure levels (systolic ≥120 mmHg, diastolic ≥100 mmHg), creatinine clearance ≥50 mL/min, or clinical conditions such as diabetes mellitus, congestive heart failure, history of cerebral pathology, and peripheral arterial disease. Since the presence of MAU reflects long-term detrimental effects on the cardiovascular system, these results indicate the high, and in many cases hidden, burden of cardiovascular diseases among the hypertensive patients seen by cardiologists. This article discusses the main results of the study and the potential implications of ongoing analyses included in the core clinical study programme.

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Prevalence of Microalbuminuria and Its Association with Pulse Pressure in a Multi-Ethnic Population in Amsterdam, The Netherlands

Cited by 3 publications

References 80 publications

Ethnic differences in the association between waist-to-height ratio and albumin-creatinine ratio: the observational SUNSET study

Ethnic differences in the association between waist-to-height ratio and albumin-creatinine ratio: the observational SUNSET study

Lower frequency of the 5/5 homozygous CNDP1 genotype in South Asian Surinamese

Overview of the i-SEARCH Global Study

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