Prevalence of microalbuminuria in type 2 diabetes mellitus at a diabetes centre in southern India

Varghese, Ancy; Deepa, R; Mohan, Rema; Mohan, Viswanathan

doi:10.1136/pmj.77.908.399

Cited by 140 publications

(164 citation statements)

References 30 publications

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“…13 K. G Santosh et al, have shown that glycosylated hemoglobin, MA and the duration of diabetes mellitus were independently related to DR. 14 In our research study, HbA1c and MA in diabetic patients with DR were positively correlated, which was similar to the findings reported by some previous study. [15][16][17][18] In another study, there was no significant association of MA with HbA1c, but there was a strong association with fasting blood glucose, which was similar to an earlier study. 19 Poor glycemic control (HbA1c) is a risk factor of MA.…”

Section: Discussionsupporting

confidence: 74%

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The predictive power of microalbuminuria in diagnosing diabetic retinopathy in adults with Type II diabetes mellitus

2020

IJCBR

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Introduction: Diabetes Mellitus is one of the most common metabolic disorders, resulting in hyperglycemia and is associated with micro and macro vascular complications. Diabetic retinopathy (DR) is a widely accepted cause of blindness in adults. The duration of diabetes, glycemic control and microalbuminuria (MA) have been implicated in the onset and progression of DR. Materials and Methods: The aim of our study is to correlate FBS, PPBS, HbA1c and microalbuminuria with diabetic retinopathy and to find out MA as the predictor of DR in T2DM patients. Our study included, 50 T2DM patients with DR, 50 T2DM patients without DR and 50 controls of both sex in the age group of 40 -60 years. Fasting blood sugar (FBS) and post prandial blood sugar (PPBS) were estimated by Glucose Oxidase method, glycated hemoglobin (HbA1c) by Ion Exchange Resin Method and urine samples were assayed for Microalbumin by Immunoturbidimetric assay and DR was diagnosed using Fundoscopy. Results: In our study, levels of urinary microalbumin, FBS, PPBS and HbA1c in T2DM patients with DR is increased than T2DM patients without DR than the control group, which is highly significant (p <0.001). HbA1c and Microalbuminuria in T2DM are positively correlated. All the parameters (FBS, PPBS, HbA1c and microalbuminuria) in group A cases are positively correlated with grades of Diabetic Retinopathy. Conclusion: Microalbuminuria and diabetic retinopathy are closely associated in T2DM patients and is a reliable marker which can predict the risk for the development of DR. All patients with MA should undergo regular retinal evaluation.

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Section: Discussionsupporting

confidence: 74%

“…12 there is a significant statistical correlation between the prevalence of MA and the presence of diabetic retinopathy. [21][22][23] …”

Section: Discussionmentioning

confidence: 99%

The predictive power of microalbuminuria in diagnosing diabetic retinopathy in adults with Type II diabetes mellitus

2020

IJCBR

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“…The prevalence of microalbuminuria was not statistically different from the males and females. The similar study was conducted in India by Varghese et al reported an increased prevalence of microalbuminuria in Indian men compared with Indian women [9]. In our study, there was statistically significant difference in FBS and postprandial blood sugar in both groups.…”

Section: Geetha and Shanmugasundaramsupporting

confidence: 73%

“…Previous studies have also shown positive correlation of microalbuminuria with the age of Type 2 diabetes patients [13,14]. A similar study conducted by Varghese et al reported that there was statistical correlation was found between microalbuminuria and age [9]. Our study has shown significant differences between both groups in baseline characteristics of BMI and but the correlation between microalbuminuria and BMI was not seen.…”

Section: Geetha and Shanmugasundaramcontrasting

confidence: 41%

Correlation of Microalbuminuria With Age, Duration, Glycated Hemoglobin, Blood Sugar Levels, Blood Pressure and Renal Parameters of Type 2 Diabetes Patients

Geetha

Shanmugasundaram

2017

Asian J Pharm Clin Res

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Objectives: Microalbuminuria is the strongest predictor of diabetic nephropathy, which is the main cause of morbidity and mortality. The aim of the study is to determine the prevalence of microalbuminuria in Type 2 diabetes patients and to evaluate the relation between the microalbuminuria and age, duration, glycated hemoglobin (HbA1c), blood sugar levels, blood pressure (BP), and renal parameters of Type 2 diabetes patients. Methods:The prospective study includes 115 patients with Type 2 diabetes, visiting in outpatient diabetes hospital, Chennai. The case reports of the patients diagnosed with blood sugar, HbA1c level BP and renal parameters of Type 2 diabetes patients were recorded and compared with microalbuminuria. Statistical analysis was carried out using student t-test and Pearson correlation. Results:The study revealed that the prevalence of microalbuminuria in this study was 27.82%. Incidence of microalbuminria increases with age, duration of diabetes, blood sugar levels, and hypertension. There is no association of body mass index and sex on the prevalence of microalbuminuria in Type 2 diabetes mellitus. Creatinine clearance has shown a weak negative correlation with microalbuminuria in our study. Conclusion:The present study showed that there is a weak positive correlation of microalbuminuria with blood sugar levels, duration and systolic BP. There is a weak negative correlation of creatinine shows that impairment in the kidney function.

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“…Expected protein excretion was calculated by the protein/ creatinine ratio method and overt proteinuria was defined as Z300 mg/day. 27 …”

Section: Biochemical Estimationsmentioning

confidence: 99%

Rage gene promoter polymorphisms and diabetic retinopathy in a clinic-based population from South India

Ramprasad

Radha

Mathias

et al. 2006

Eye

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Purpose The main objective of this study was to evaluate if the À429T/C, À374T/A and 63 bp deletion polymorphisms in the RAGE gene are associated with diabetic retinopathy (DR) among Type 2 diabetic subjects in a clinicbased population from South India. Methods We screened 149 normal glucose tolerant subjects (NGT), 189 Type 2 diabetes subjects without retinopathy (DM) and 190 subjects with DR for these polymorphisms using the PCR-RFLP method. DR was diagnosed by grading color fundus photography. Logistic regression models were used to evaluate the association of individual polymorphisms with DR. Expectationmaximization algorithms were implemented in haplotype tests of association to examine the combined effects of À429T/C and À374T/A polymorphisms on DR. Results The allelic frequencies of À429T are 0.83 in NGT, 0.84 in DM and 0.85 in DR subjects, and that of À374T are 0.93 in NGT, 0.92 in DM and 0.88 in DR subjects. The À374 polymorphism was found to be associated with non-proliferative retinopathy when this subgroup was compared to the DM group (OR ¼ 1.814, 95% CI ¼ 1.005-3.273). However, this association was not obvious when both the subphenotypes of DR (the nonproliferative and proliferative DR groups) were studied jointly. We found no evidence for associations between the À429T/C polymorphism and the DR phenotype. Finally, extension to a 2-SNP haplotype did not reveal any significant statistical difference between the groups (P ¼ 0.668).

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Prevalence of microalbuminuria in type 2 diabetes mellitus at a diabetes centre in southern India

Cited by 140 publications

References 30 publications

The predictive power of microalbuminuria in diagnosing diabetic retinopathy in adults with Type II diabetes mellitus

The predictive power of microalbuminuria in diagnosing diabetic retinopathy in adults with Type II diabetes mellitus

Correlation of Microalbuminuria With Age, Duration, Glycated Hemoglobin, Blood Sugar Levels, Blood Pressure and Renal Parameters of Type 2 Diabetes Patients

Rage gene promoter polymorphisms and diabetic retinopathy in a clinic-based population from South India

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