Prevalence of Migraine and Raynaud’s Phenomenon in Japanese Patients With Vasospastic Angina

Nakamura, Yukio; Shinozaki, Norihiko; Hirasawa, Motoaki; Kato, R; Shiraishi, Kou-ichi; Kida, Hiroshi; Usuda, Kazuo; Ishikawa, Tadao

doi:10.1253/jcj.64.239

Cited by 40 publications

(30 citation statements)

References 14 publications

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“…79 There are some genetic factors that link these conditions among certain racial groups but a common mechanism has not been proven. There are case reports of acetylcholine induced CS in Kawasaki disease and ChurgStrauss syndrome.…”

Section: Association With Other Disordersmentioning

confidence: 99%

The Mystery of Coronary Artery Spasm

Ajani

Yan

2007

Heart, Lung and Circulation

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Section: Association With Other Disordersmentioning

confidence: 99%

The Mystery of Coronary Artery Spasm

Ajani

Yan

2007

Heart, Lung and Circulation

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“…VA is relatively common in East Asians and is frequently observed in normal coronary arteries (7, 8). Moreover, it has been reported that the prevalence of Raynaud's phenomena or migraine in VA patients is relatively high (9-11). These findings suggest that VA may be a manifestation of generalized smooth muscle contractile disorder, and that an abnormal contractile response in the coronary microcirculation may also be present.…”

Section: Introductionmentioning

confidence: 99%

Changes of Coronary Blood Flow in Vasospastic Angina under Cold Stimulation by Transthoracic Doppler Echocardiography

et al. 2005

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This study was done to evaluate changes of microvascular function under cold stimulation by measuring coronary flow velocities (CFVs) in vasospastic angina (VA) patients using transthoracic Doppler echocardiography (TTDE). 14 patients with VA and 15 healthy controls were included. CFVs were measured at the distal left anterior descending coronary artery by TTDE at baseline and under cold stimulation. Hyperemia was induced by intravenous adenosine infusion (140 µg/kg/min). At baseline, CFVs and coronary flow reserve (CFR) were not different between controls and VA patients. Under cold stimulation, the degree of increment of CFV with adenosine was lower in VA patients than in controls. Comparing baseline with cold stimulation, coronary flow reserve (CFR) increased (3.1±0.7 to 3.8±1.0, p=0.06) in controls. In contrast, in VA patients, CFR was decreased (2.8±0.9 to 2.6±0.7, p=0.05) and coronary vascular resistance index markedly increased (0.35 to 0.43, p=0.01). Throughout the study, no patient experienced chest pain or ECG changes. In VA patients, CFR was preserved at baseline, but coronary blood flow increase in response to cold stimulation was blunted and CFR was decreased. These findings suggest that endothelial dependent vasodilation is impaired at the coronary microvascular and the epicardial artery level in VA under cold stimulation.

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“…These include hypertension (HPT), Raynaud's phenomenon (RP), migraine (MIG) and coronary artery disease (CAD) [1-5]. Whether these associations are the consequences of a shared environmental risk factor or represent an underlying propensity to develop the conditions through a common biological mechanism remains controversial.…”

Section: Introductionmentioning

confidence: 99%

A common genetic factor underlies hypertension and other cardiovascular disorders

Williams

Cherkas

Spector

et al. 2004

BMC Cardiovasc Disord

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BackgroundCertain conditions characterised by blood vessel occlusion or vascular spasm have been found to cluster together in epidemiological studies. However the biological causes for these associations remain controversial. This study used a classical twin design to examine whether these conditions are linked through shared environmental exposures or by a common underlying genetic propensity to vasospasm.MethodsWe investigated the association between hypertension, migraine, Raynaud's phenomenon and coronary artery disease in twins from a national register. Phenotype status was determined using a questionnaire and the genetic and environmental association between phenotypes was estimated through variance components analysis.ResultsResponses were obtained from 2,204 individuals comprising 525 monozygotic and 577 dizygotic pairs. There was a significant genetic contribution to all four traits with heritabilities ranging from 0.34 to 0.64. Multivariate model-fitting demonstrated that a single common genetic factor underlies the four conditions.ConclusionsWe have confirmed an association between hypertension, migraine, Raynaud's phenomenon and coronary artery disease, and shown that a single genetic factor underlies them. The demonstration of a shared genetic factor explains the association between them and adds weight to the theory of an inherited predisposition to vasospasm.

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Prevalence of Migraine and Raynaud’s Phenomenon in Japanese Patients With Vasospastic Angina

Cited by 40 publications

References 14 publications

The Mystery of Coronary Artery Spasm

The Mystery of Coronary Artery Spasm

Changes of Coronary Blood Flow in Vasospastic Angina under Cold Stimulation by Transthoracic Doppler Echocardiography

A common genetic factor underlies hypertension and other cardiovascular disorders

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