Prevalence of mild behavioural impairment: a systematic review and meta‐analysis

Abstract

Aim Mild behavioural impairment (MBI) is a neurobehavioural syndrome characterized by emergent neuropsychiatric symptoms in later life. There has been no systematic review or meta‐analysis on the prevalence of MBI. The main aim of the study is to calculate the pooled prevalence of MBI. Methods A search of the literature on MBI in mild cognitive impairment (MCI), cognitively normal (CN), and subjective cognitive impairment (SCI) and CN but at risk (CN‐AR) subjects published between 1 January 2003 and 28 September 2020 was conducted. Meta‐analysis using a random effects model was performed to determine the pooled estimate of the prevalence of MBI. Meta‐regression was performed to identify factors contributing to the variance of prevalence rate. A systematic review was also performed to study the impact of MBI in cognitive outcomes and its correlation to the pathology and genetics of Alzheimer's disease. Results Eleven studies conducted among 15 689 subjects underwent meta‐analysis, revealing the pooled prevalence of MBI to be 33.5% (95% confidence interval (CI): 22.6%–46.6%). Seven studies conducted among 1358 MCI subjects underwent meta‐analysis, revealing the pooled prevalence to be 45.5% (95%CI: 36.1%–55.3%). Four studies conducted among 13 153 CN subjects underwent meta‐analysis, revealing the pooled prevalence to be 17.0% (95%CI: 7.2%–34.9%). Five studies conducted among 1158 SCI or CN‐AR subjects underwent meta‐analysis, revealing the pooled prevalence to be 35.8% (95%CI: 21.4%–53.2%). A systematic review of 13 studies showed that MBI has a significant impact on cognitive deterioration and is associated with the pathology and genetics of Alzheimer's disease. Conclusions In MCI, CN, and SCI and CN‐AR subjects, MBI is common. Our finding is potentially useful in planning future clinical trials.

Suicide risk in first year after dementia diagnosis in older adults

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Depression and Dementia in Older Adults: A Neuropsychological Review

“…Further, this syndrome has already been recognized in the community and in clinical research cases and has been shown to be present not only in many older patients with sustained neuropsychiatric symptoms or MCI but also in some cognitively normal older adults [ 79 - 82 ]. A recent a systematic review and meta-analysis based on 11 studies including 15,689 subjects (older adults) has showed that the pooled prevalence of MBI was 33.5% (95% confidence interval: 22.6%-46.6%) [ 83 ]. Additionally, 18.2% of the older adults without dementia were found to have MBI [ 84 ].…”

Prevalence of mild behavioural impairment domains: a meta‐analysis

“…The MBI‐C is a 34‐item questionnaire, providing information on later life emergent symptoms and behaviours that have been present for at least 6 months, as described in the MBI criteria. MBI is common among cognitively normal (CN), subjective cognitive impairment (SCI), and MCI subjects, with a pooled prevalence of 17%, 35.8%, and 45.5%, respectively according to a recent meta‐analysis incorporating various case ascertainment approaches 19 …”