Prevalence of mild cognitive impairment in an elderly community sample

Schröder, Johannes; Kratz, B.; Pantel, Johannes; Minnemann, E.; Lehr, Ursula; Sauer, H.

doi:10.1007/978-3-7091-7508-8_5

Cited by 94 publications

(58 citation statements)

References 22 publications

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“…ILSE is a prospective study on adult development in Germany based on two birth cohorts born in 1930-32 and 1950-52. 12 Subjects were randomly identified and recruited using the community registers. As it is compulsory for each resident in Germany aged 16 years and above to be registered, this recruitment procedure yielded an almost representative sample from each community.…”

Section: Study Samplementioning

confidence: 99%

Prevalence of clinical and radiographic signs of osteoarthrosis of the temporomandibular joint in an older persons community

Schmitter

Essig²,

Seneadza³

et al. 2010

Dentomaxillofacial Radiology

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Objectives: The aim was to assess the prevalence of osteoarthrosis (OA) in the temporomandibular joint (TMJ) in a sample of older people by use of contrast agentenhanced MRI. Methods: 30 patients (73-75 years old) were drawn from a representative sample and were examined clinically. The shape of the condyle was assessed using gadolinium-enhanced MR images, which were evaluated by two independent raters. Statistical assessment was performed by using descriptive statistics, the x 2 test and kappa statistics. Results: Agreement between raters was excellent with respect to the presence/absence of OA (kappa 5 0.8). Only one subject reported pain in a TMJ. Fine and/or coarse crepitus was not heard in any subject. MRI showed that 70% displayed signs of OA in at least one TMJ. There were no gender-related differences in the prevalence of OA (P . 0.05). Conclusion: Gadolinium-enhanced MRI showed that OA of the TMJ is common in older people (70%), although the prevalence of clinical signs of OA is very low.

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Section: Study Samplementioning

confidence: 99%

Prevalence of clinical and radiographic signs of osteoarthrosis of the temporomandibular joint in an older persons community

Schmitter

Essig²,

Seneadza³

et al. 2010

Dentomaxillofacial Radiology

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“…0.8) were recruited among the Heidelberg subsample of the interdisciplinary longitudinal study on adult development (ILSE) which is conducted in Heidelberg and Leipzig (Germany). Cognitive performance was assessed using a previously described extensive neuropsychological test battery [17] Mild cognitive impairment was defined by Levy's criteria of Aging-associated cognitive decline [18].…”

Section: Subject Selectionmentioning

confidence: 99%

Comparison of manual direct and automated indirect measurement of hippocampus using magnetic resonance imaging

Giesel

Thomann

Hahn

et al. 2008

European Journal of Radiology

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Purpose: Objective quantification of brain structure can aid diagnosis and therapeutic monitoring in several neuropsychiatric disorders. In this study, we aimed to compare direct and indirect quantification approaches for hippocampal formation changes in patients with mild cognitive impairment and Alzheimer's disease (AD). Methods and materials: Twenty-one healthy volunteers (mean age: 66.2), 21 patients with mild cognitive impairment (mean age: 66.6), and 10 patients with AD (mean age: 65.1) were enrolled. All subjects underwent extensive neuropsychological testing and were imaged at 1.5 T (Vision, Siemens, Germany; T1w coronal TR = 4 ms, Flip = 13• , FOV = 250 mm, Matrix = 256 × 256, 128 contiguous slices, 1.8 mm). Direct measurement of the hippocampal formation was performed on coronal slices using a standardized protocol, while indirect temporal horn volume (THV) was calculated using a watershed algorithm-based software package (MeVis, Germany). Manual tracing took about 30 min, semi-automated measurement less than 3 min time.Results: Successful direct and indirect quantification was performed in all subjects. A significant volume difference was found between controls and AD patients (p < 0.001) with both the manual and the semi-automated approach. Group analysis showed a slight but not significant decrease of hippocampal volume and increase in temporal horn volume (THV) for subjects with mild cognitive impairment compared to volunteers (p < 0.07). A significant correlation (p < 0.001) of direct and indirect measurement was found. Conclusion: The presented indirect approach for hippocampus volumetry is equivalent to the direct approach and offers the advantages of observer independency, time reduction and thus usefulness for clinical routine.

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“…Yet, empirical identification of key MCI caregiver stressors is important because the population of elderly individuals with MCI is growing, in part, due to better diagnostic tools for this condition (Kiovisto et al, 1995;Hanninen et al, 1996;Schroder et al, 1998). Information regarding the burden and the potential mental health impact on spousal caregivers of MCI patients will help us understand if these outcomes are distinct from those observed in spouses of persons with diagnosable dementia syndromes such as Alzheimer's disease.…”

Section: Introductionmentioning

confidence: 99%

Caregiving burden and psychiatric morbidity in spouses of persons with mild cognitive impairment

Garand

Dew

Eazor

et al. 2005

Int J Geriat Psychiatry

147

122

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SUMMARYBackground-While the deleterious psychosocial and mental health effects of dementia caregiving are firmly established, very little is known about the burdens or psychiatric outcomes of providing care to a spouse with less severe cognitive impairment, such as mild cognitive impairment (MCI). We characterized the nature and level of caregiver burden and psychiatric morbidity in spouses of persons diagnosed with MCI.

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Prevalence of mild cognitive impairment in an elderly community sample

Cited by 94 publications

References 22 publications

Prevalence of clinical and radiographic signs of osteoarthrosis of the temporomandibular joint in an older persons community

Prevalence of clinical and radiographic signs of osteoarthrosis of the temporomandibular joint in an older persons community

Comparison of manual direct and automated indirect measurement of hippocampus using magnetic resonance imaging

Caregiving burden and psychiatric morbidity in spouses of persons with mild cognitive impairment

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