Prevalence of Mild Cognitive Impairment and Dementia among the Elderly Population of Qena Governorate, Upper Egypt: A Community-Based Study

Khedr, Eman M.; Fawi, Gharib; Abbas, Mohammed; Mohammed, Talal A.; El-Fetoh, Noha Abo; Attar, Ghada Al; Noaman, Mostafa M.; Zaki, Ahmed

doi:10.3233/jad-142655

Cited by 37 publications

(46 citation statements)

References 72 publications

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“…14–19 The six eligible studies were conducted in four governorates in Egypt between 1993 and 2013 (Table 1; Figure 2). Two studies were conducted in the New Valley governorate,15,16 and two were conducted in the Red Sea governorate 17,18.…”

Section: Resultsmentioning

confidence: 99%

“…Four studies were performed on subjects aging ≥50,15–18 and the other two studies were conducted on people aging ≥60 14,19. Most studies did not report substance-induced dementia or dementia due to alcohol because of the sociocultural characteristics of the communities 14,16–18.…”

Section: Resultsmentioning

confidence: 99%

“…Most studies did not report substance-induced dementia or dementia due to alcohol because of the sociocultural characteristics of the communities 14,16–18. In addition, two studies reported dementia in communities with high prevalence of Parkinson’s disease,12,19 one study reported high prevalence of cerebral palsy in the community,17 and one study reported dementia due to chronic renal diseases or hepatic disease because of schistosomiasis 14. In most of the studies, the percentage of nonrespondents ranged from 1% to 3.7% 14,16,17,19…”

Section: Resultsmentioning

confidence: 99%

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Prevalence of dementia in Egypt: a systematic review

Elshahidi¹,

Elhadidi²,

Sharaqi³

et al. 2017

NDT

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BackgroundWith the growing prevalence of dementia worldwide, two-third of the people with dementia are projected to be from the developing countries by 2050.AimThis study reviews the literature regarding dementia prevalence in Egypt.MethodsSix databases were systematically searched from their dates of inception till July 2016. Studies published in English and reporting dementia prevalence among nonhospitalized individuals after clinical examinations were considered eligible. References were screened independently by two reviewers in two steps: 1) abstract screening and 2) full-text reviewing. In addition, quality of the included studies was assessed using the Newcastle–Ottawa scale.ResultsOf the 1,630 references retrieved, six studies (n=28,029 participants) met our inclusion criteria. In all studies, dementia was ascertained using a three-phase survey (Phase I: screening, Phase II: clinical diagnosis, Phase III: laboratory investigations). The dementia prevalence ranged from 2.01% to 5.07%. Dementia increased with age, with the rapid increase among those aging ≥80. Also, its prevalence was higher among illiterate groups than among educated groups. Included studies were of low risk of bias.ConclusionDementia prevalence in Egypt demands including people with dementia in the health care system and promoting the awareness of dementia among the public. Also, more epidemiological studies in this field are needed.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Prevalence of dementia in Egypt: a systematic review

Elshahidi¹,

Elhadidi²,

Sharaqi³

et al. 2017

NDT

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“…Additionally, in case of insufficient incidence information for 2 other MENA countries, Egypt [14, 15] and Israel-Palestine [16, 17], cumulative incidence was estimated by using 2 (earliest-to-latest) prevalence surveys [18] of the same nature, that is, same population and methodological details as much as feasible (Bhalla, unpubl. data).…”

Section: Methodsmentioning

confidence: 99%

Incidence and Risk Profile of Dementia in the Regions of Middle East and North Africa

et al. 2018

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Background: The risk of dementia is reported as “epidemic” and “looming” over the Middle East and North Africa (MENA) region. For this, we performed a multi-language review and feasible analysis on the incidence of dementia to offer apt conclusions. Methods: Totally, 3 databases (Magiran, Scientific Information Database, and PubMed) and 1 non-database source (Google) were searched in French, English, and Persian by using specific keywords and their combinations. All searches were independent and had no restriction for the year or type of publication. We also calculated cumulative incidence of dementia for Egypt and Israel-Palestine from relevant prevalence estimates by using standard formula. Results: Little information on incidence was available, sparing Israel (2.4/100,000/year; pre-senile). Ten (48.0%) countries had none-to-little information (of any kind) on dementia, indicating considerable awareness deficit in this region. Cumulative incidence of dementia in Egypt and Israel-Palestine was 2.7% over 20 years (55 new cases) and 14.7% (130 new cases) over 6 years, respectively. In Lebanon, cumulative incidence was 7.5% over 20 years. Data looked across dementia-related factors (i.e., fertility rate, polygamy, violence, hypovitaminosis D, diabetes, hypertension, life expectancy, age structure) did not seem to support epidemic proportions of dementia for MENA. Conclusions: MENA is youthful and dementia here is neither likely to be an epidemic nor looming over. The only possible exception might be Arab pocket in Israel. To us, previous attributions on dementia do not seem to be based on the realities of this region and, therefore, may prevent pragmatic addressal of dementia. Lastly, values-based collaborations are invited to jointly fill the awareness deficit in a unique low-cost manner.

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“…In the study of Khedr et al (2012), the overall crude prevalence of PD in the city of Assiut was 557 per 100,000 for all ages and 2,748 per 100,000 for individuals aged of 50 or more, where these rates were higher than in other Arab countries and several European countries. Another survey was carried out in Qena governorate which showed that the crude prevalence rate of PD was 436 in every 100,000 persons for all ages, and 2534 per 100,000 aged 50 or more (Khedr et al, 2015). Additionally, the prevalence rate of PD in the district of Al Kharga was found to be 213.15 per 100,000 individuals aged 40 or more; showing lower rate than Nile valley governorates of Assiut and Qena.…”

Section: Introductionmentioning

confidence: 99%

Investigation of the Possible Neuroprotective Effect of an Estrogen Receptor Beta Agonist Against Rotenone-Induced Parkinson’s Disease in Rats

Salama¹

2016

Al-Azhar Journal of Pharmaceutical Sciences

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Parkinson's disease (PD) is the second most common neurodegenerative disorder. Androst-5-ene-3β, 17β-diol (ADIOL), an estrogen receptor (ER) β agonist, was found to induce a transrepressive mechanism, which selectively amend the extent of neuroinflammation and, in turn, neurodegeneration; nevertheless, its effect on PD has not yet been revealed. In consequence, our study was designed to examine the possible neuroprotective effect of ADIOL against a rotenone (ROT)-induced PD in rats. Reduction in the nuclear factor-kappa B (NF-κB) levels and the expression of downstream inflammatory mediators was detected in the SN upon pre-treatment with ADIOL at the dose of 0.35 mg/kg/day. Likewise, light microscopy (LM) examination showed improvement in the number of viable neurons in the SN pars compacta (SNpc). In conclusion, the current study confirmed the ability of ADIOL to reduce neuroinflammation and, in turn, neurodegeneration process as well as motor impairment in PD.

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Prevalence of Mild Cognitive Impairment and Dementia among the Elderly Population of Qena Governorate, Upper Egypt: A Community-Based Study

Abstract: Overall, the prevalence rate of MCI and dementia were lower in Qena/Egypt than in other countries. Advanced age, illiteracy, and living in an industrial area were found to be associated with dementia.

Cited by 37 publications

References 72 publications

Prevalence of dementia in Egypt: a systematic review

Prevalence of dementia in Egypt: a systematic review

Incidence and Risk Profile of Dementia in the Regions of Middle East and North Africa

Investigation of the Possible Neuroprotective Effect of an Estrogen Receptor Beta Agonist Against Rotenone-Induced Parkinson’s Disease in Rats

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