Prevalence of misregistration between SPECT and CT for attenuation-corrected myocardial perfusion SPECT

Goetze, Sibyll; Wahl, Richard L.

doi:10.1016/j.nuclcard.2006.12.325

Cited by 86 publications

(48 citation statements)

References 5 publications

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“…It is relevant that even low-quality CT scans for attenuation correction provide clinically useful information. Goetze et al reported that for 10% of 200 patients, noncardiacrelated abnormal findings were detected (69,70). Similar data with even higher incidence rates are available from cardiac CT studies (74,75).…”

Section: Use Of Ct For Attenuation Correctionmentioning

confidence: 68%

“…However, a potential misalignment between emission and transmission data poses the risk of incomplete correction and thus artificial perfusion defects and requires careful quality control to avoid reconstruction artifacts. PET/CT (67,68) and SPECT/CT (69,70) studies have shown that the frequency of misalignment is high (#50%) and that the consequences are clinically significant. Fortunately, a recent study with a digital phantom showed that the effects of misalignment are less severe for SPECT/CT than for PET/CT, mainly because of reduced spatial resolution (71).…”

Section: Use Of Ct For Attenuation Correctionmentioning

confidence: 99%

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Spect/Ct

Buck¹,

Nekolla²,

Ziegler³

et al. 2008

J Nucl Med

284

149

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In view of the commercial success of integrated PET/CT scanners, there is an increasing interest in comparable SPECT/CT systems. SPECT in combination with CT enables a direct correlation of anatomic information and functional information, resulting in better localization and definition of scintigraphic findings. Besides anatomic referencing, the added value of CT coregistration is based on the attenuation correction capabilities of CT. The number of clinical studies is limited, but pilot studies have indicated a higher specificity and a significant reduction in indeterminate findings. The superiority of SPECT/CT over planar imaging or SPECT has been demonstrated in bone scintigraphy, somatostatin receptor scintigraphy, parathyroid scintigraphy, and adrenal gland scintigraphy. Also, rates of detection of sentinel nodes by biopsy can be increased with SPECT/CT. This review highlights recent technical developments in integrated SPECT/CT systems and summarizes the current literature on potential clinical uses and future directions for SPECT/CT in cardiac, neurologic, and oncologic applications.

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Section: Use Of Ct For Attenuation Correctionmentioning

confidence: 68%

Section: Use Of Ct For Attenuation Correctionmentioning

confidence: 99%

Spect/Ct

Buck¹,

Nekolla²,

Ziegler³

et al. 2008

J Nucl Med

284

149

View full text Add to dashboard Cite

show abstract

“…Despite the integration of high-end CT devices with the capability to perform state-of-the-art coronary CT angiography into nuclear scanners to form dedicated cardiac hybrid scanners, manual image coregistration may remain indispensable. Studies with X-ray based attenuation correction have reported that automated coregistration of CT and SPECT images is often unreliable and manual correction for misalignment is needed in the vast majority of the cases (26,27).…”

Section: Definition and General Aspects Of Hybrid Imagingmentioning

confidence: 99%

Cardiac hybrid imaging: state-of-the-art

Kaufmann

2009

Ann Nucl Med

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“…For those SPECT systems equipped with CT attenuation correction devices, an important QA step is to verify correct registration of CT and SPECT transaxial sections, as otherwise perfusion defect artifacts can result. 13 Looking to the future, developments in detector design and reconstruction algorithms have expanded the types of physiologic parameters that can be computed in Nuclear Cardiology, and these newer procedures will require additional QA steps. In recent years, several different SPECT system designs have become available that do not physically rotate around the patient, but rather collect data simultaneously from all projections over a 1808 arc about the patient's thorax.…”

mentioning

confidence: 99%

Gated SPECT myocardial perfusion imaging quality assurance in current and future practice

Nichols

Tosh

2017

Journal of Nuclear Cardiology

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Journal of Nuclear Cardiology, Malek et al 2 review some of the important elements of QA procedures required to produce reliable computations of left ventricular (LV) perfusion and function parameters from gated SPECT myocardial perfusion imaging (MPI) data for the Cedars-Sinai QGS program, 3 which is a commonly used commercially available MPI analysis software package. While other algorithms operate on somewhat different principles and LV modeling assumptions, 4,5 all MPI software packages have in common the automated identification of the LV outflow tract valve plane, endocardial and epicardial borders. As the authors remind us, failure to ensure the appropriate locations of LV limits can compromise the validity of summed stress scores, summed rest scores, ejection fractions, LV volumes, LV mass, lung:heart count ratios, and transient ischemic dilatation, among other parameters.Additional parameters that can be compromised by sub-optimal LV valve plane placement include phase maps and the computed phase parameters derived from them, including phase histogram bandwidth (BW), phase standard deviation (SD), skewness, and kurtosis metrics. 6 If the LV valve plane is placed too far out beyond the end of the basal myocardium, the algorithms will misinterpret random variations of background counts as contributing to the number of pixels with contractions far from the actual phase at which the majority of regional LV contractions occurred, thereby leading to the false impression of asynchronous LAD and/or RCA territories, and an inaccurate broadening of the phase histogram curve with subsequent incorrectly large values of phase BW and SD. As phase measurements are a relatively recent extension of MPI study computations, establishing reliable values of these is important to enable capitalizing on the added dimension this has provided when evaluating patients with CAD. 7 When first presented with a newly acquired MPI dataset to be processed, users of analysis software packages frequently will first be presented with screens displaying the automated attempts to localize the LV centers and boundaries. As Malek et al 2 point out, it is important to verify that these initial automated definitions are correct, or to modify them to best conform to the visual impression of optimally appropriate choices.

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Prevalence of misregistration between SPECT and CT for attenuation-corrected myocardial perfusion SPECT

Cited by 86 publications

References 5 publications

Spect/Ct

Spect/Ct

Cardiac hybrid imaging: state-of-the-art

Gated SPECT myocardial perfusion imaging quality assurance in current and future practice

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