Prevalence of Mitral Valve Prolapse in Saudi Sickle Cell Disease Patients in Dammam — A Prospective-Controlled Echocardiographic Study

Husain, Akhtar; Ladipo, G. O. A.; Abdul-Mohsen, Mohammed Fakhry; Knox‐Macaulay, H. H. M.

doi:10.5144/0256-4947.1995.244

Cited by 2 publications

(1 citation statement)

References 34 publications

(54 reference statements)

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“…In another study performed in Saudi Arabia, Hussain et al reported no statistically significant difference in the prevalence of MVP in four age-matched groups of normal control subjects, SCD, sickle cell trait, and patients with other anemias. 16 The prevalence of MVP in this study ranged from 13.3% to 21.4%, the lowest of which was in the SCD group. Our study found similar results with MVP present in 12.4% of patients with NRVHD.…”

Section: Discussionmentioning

confidence: 48%

Prevalence and predictors of non-rheumatic valvular heart disease in patients with sickle cell disease: insights from the National In-Patient Database in 2016 and 2017

Quelal

Torres

Shahi

et al. 2023

Journal of Investigative Medicine

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Sickle cell disease (SCD) life expectancy has increased in high-income countries, approaching the fifth decade in the United States. Aging in SCD has raised concerns about chronic organ damage due to adaptative and maladaptive cardiac remodeling. This study aims to assess the prevalence and predictors of non-rheumatic valvular heart disease (NRVHD) in SCD patients using the United States National Inpatient Sample database from 2016 and 2017. We conducted a weighted analysis on SCD patients during their index hospitalization. We obtained the prevalence of NRVHD and calculated adjusted odds ratios to identify the associated demographic, social, and clinical characteristics using multivariable logistic regression. We identified 192,460 SCD admissions during 2016 and 2017. Of them, 2450 (1.3%) had NRVHD. Mitral insufficiency (MI) was the most common NRVHD present in 52% of the cases. Mitral valve prolapse represented 12.4%, while aortic stenosis and aortic insufficiency in 10.8% and 12.7%, respectively. Right-sided NRVHD had a lower prevalence, with 17.1% of patients having tricuspid insufficiency (TI) and 6.3% pulmonary insufficiency. There were no cases of mitral, tricuspid, or pulmonary stenosis. Characteristics associated with the presence of NRVHD in SCD were secondary pulmonary hypertension, congestive heart failure, chronic kidney disease, and female sex. NRVHDs, especially MI and TI, are comorbidities in SCD. Literature is scarce on this topic. The predictors found for its occurrence could help address modifiable factors that can positively affect patients with SCD who, due to the natural history of the disease, are at risk of developing NRVHD.

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Section: Discussionmentioning

confidence: 48%

Prevalence and predictors of non-rheumatic valvular heart disease in patients with sickle cell disease: insights from the National In-Patient Database in 2016 and 2017

Quelal

Torres

Shahi

et al. 2023

Journal of Investigative Medicine

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Complicaciones cardiopulmonares en anemia de células falciformes

Rojas-Jiménez¹,

Valle²,

Yabur-Espitia³

2013

Archivos de Cardiología de México

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Sickle cell anemia, considered the most prevalent genetic disease among African Americans, is a disease with autosomal recessive inheritance pattern, characterized by the production of hemoglobin S. This abnormal protein polymerizes and facilitates the formation of fibrillar aggregates that alters the erythrocyte morphology. The stiffness of the red blood cells hinders the adequate transit across microcirculation, leading to hemolysis and increased blood viscosity, which ease thrombogenesis and vascular occlusion, resulting in tissue ischemia and microinfarcts. This disease has a high rate of morbidity and mortality, especially in the first three years of life, when a rapid diagnosis and appropriate treatment are essential. Cardiovascular complications such as heart failure and pulmonary hypertension may develop independently, and each one contributes to increased mortality, being the combination of both risk factors, an important aggravating factor for prognosis and a determinant indicator of mortality.

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Prevalence of Mitral Valve Prolapse in Saudi Sickle Cell Disease Patients in Dammam — A Prospective-Controlled Echocardiographic Study

Cited by 2 publications

References 34 publications

Prevalence and predictors of non-rheumatic valvular heart disease in patients with sickle cell disease: insights from the National In-Patient Database in 2016 and 2017

Prevalence and predictors of non-rheumatic valvular heart disease in patients with sickle cell disease: insights from the National In-Patient Database in 2016 and 2017

Complicaciones cardiopulmonares en anemia de células falciformes

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