Prevalence of Molar Incisor Hypomineralization among School Children Aged 9 to 12 Years in Virajpet, Karnataka, India

Mali, Pooja; Jain, Jithesh; Raju, Ananda S; Nair, Rohit; Shashidhar, Keerthan; Dsouza, Sheehan

doi:10.3889/oamjms.2019.224

Cited by 11 publications

(5 citation statements)

References 20 publications

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“…The evidence that MIH frequency varies across the world [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] is supported by the results found in the present study. The association found in the Turkish population was different from the results obtained in the cohorts from Brazil, which indeed indicates that genetic factors contributing to the MIH phenotype may vary depending on geographic origin.…”

Section: Plos Onesupporting

confidence: 82%

“…These asymmetrical lesions affect the first permanent molars, usually with the permanent incisors [4], and more recently MIH has been reported to affect canines too [5]. Prevalence of MIH varies but has been consistently reported to range between 1% and 35% in all parts of the world, with most reported frequencies around 12% [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

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Gene-environment interaction in molar-incisor hypomineralization

et al. 2021

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Molar incisor hypomineralization (MIH) is an enamel condition characterized by lesions ranging in color from white to brown which present rapid caries progression, and mainly affects permanent first molars and incisors. These enamel defects usually occur when there are disturbances during the mineralization or maturation stage of amelogenesis. Both genetic and environmental factors have been suggested to play roles in MIH’s development, but no conclusive risk factors have shown the source of the disease. During head and neck development, the interferon regulatory factor 6 (IRF6) gene is involved in the structure formation of the oral and maxillofacial regions, and the transforming growth factor alpha (TGFA) is an essential cell regulator, acting during proliferation, differentiation, migration and apoptosis. In this present study, it was hypothesized that these genes interact and contribute to predisposition of MIH. Environmental factors affecting children that were 3 years of age or older were also hypothesized to play a role in the disease etiology. Those factors included respiratory issues, malnutrition, food intolerance, infection of any sort and medication intake. A total of 1,065 salivary samples from four different cohorts were obtained, and DNA was extracted from each sample and genotyped for nine different single nucleotide polymorphisms. Association tests and logistic regression implemented in PLINK were used for analyses. A potential interaction between TGFA rs930655 with all markers tested in the cohort from Turkey was identified. These interactions were not identified in the remaining cohorts. Associations (p<0.05) between the use of medication after three years of age and MIH were also found, suggesting that conditions acquired at the age children start to socialize might contribute to the development of MIH.

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Section: Plos Onesupporting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Gene-environment interaction in molar-incisor hypomineralization

et al. 2021

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“…Davenport et al, in pilot research conducted in the USA, assessed the frequency of prevalence of MIH at 9.6% [ 31 ]. Moreover, a significantly higher prevalence of MIH was observed by Wainuiomata (14.9%) [ 32 ] in India—13.12% [ 33 ], Dubai—27.2% [ 34 ], Saudi Arabia—15.2% [ 35 ], and Lebanon—26.7 % [ 36 ]. To establish the accurate frequency of prevalence of MIH in Poland, thorough research must be carried out in Upper Silesia as well as other parts of Poland.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Possible Etiological Factors of Molar-Incisor Hypomineralization (MIH) in Population of Silesian Children in Poland: A Pilot Retrospective Cohort Study

Ilczuk-Rypuła

Zalewska

Pietraszewska

et al. 2022

IJERPH

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(1) Background: This pilot retrospective cohort research study regarded the frequency of the prevalence of molar-incisor hypomineralization (MIH) in a population of Silesian children in Poland. The evaluation of the potential environmental etiological factors was performed and the correlation between the environmental factors and MIH was analyzed. (2) Methods: A total of 613 children were randomly enrolled in the pilot study (9.0 years ± 1.9). A survey was carried out with mothers regarding the potential exposure to environmental etiological factors of MIH in their children. The patients’ clinical assessments were carried out in the dental unit. (3) Results: The frequency of prevalence of MIH in the population of Silesian children was established at the level of 6.2% (p < 0.05). MIH symptoms were significantly associated with otitis in early childhood (OR = 2.50), atopic dermatitis (OR = 5.69), and premature delivery before 38 weeks of pregnancy (OR = 2.88). (4) Conclusions: MIH was observed in 6.2% of the population of Silesian children, and there was a relationship between environmental risk factors such as otitis, atopic dermatitis, premature birth, and MIH expression. Therefore, further research is needed to determine the influence of pre-, peri-, postnatal, and prophylactic factors on the frequency and severity of MIH symptoms in children.

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“…9 On the contrary, Rai PM et al reported a prevalence of 13.2%. 10 The age range taken in the present study of 8-12 years is recommended by the EAPD. In the present study a statistical difference was observed between females and males (p=0.03), which is in disagreement to Rai PM et al 10 A meta-analysis by Lopez et al also confirmed that MIH was not not sex-related and females and males presented a non-significant difference as per results.…”

Section: Discussionmentioning

confidence: 99%

“…10 The age range taken in the present study of 8-12 years is recommended by the EAPD. In the present study a statistical difference was observed between females and males (p=0.03), which is in disagreement to Rai PM et al 10 A meta-analysis by Lopez et al also confirmed that MIH was not not sex-related and females and males presented a non-significant difference as per results. 11 In the present study, a significant difference was observed regarding the prevalence of MIH between the maxillary teeth compared to the mandibular teeth (p=0,02), which is in disagreement with Yannam SD et al 8 and Jalevik et al…”

Section: Discussionmentioning

confidence: 99%

Assessing the Prevalence of Molar-Incisor Hypomineralisation among School Children in a North Indian District

Prakrit Sharma,

Sandeep Singh Siddhu,

Tika Thapa

2022

IHRJ

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INTRODUCTION: Molar Incisor Hypomineralisation (MIH) is a dental condition which affects the first permanent molars ranging from white opacities to complete breakdown on the teeth and is considered as a matter of global concern. AIM: To assess the prevalence of MIH in school children aged 8-12 years in District Bulandshahr, Uttar Pradesh, India. MATERIALS AND METHOD: This cross-sectional study was conducted by examining 793 school children aged 8-12 years in various schools. ental examinations were conducted by four standardized examiners and four recording assistants who entered data in a pre-tested and pre-validated proforma. MIH was clinically identified by the ten-point scoring criteria given by European Academy of Pediatric Dentistry (EAPD) 2011. Data was analyzed using SPSS version 24.0 and the student’s t-test and multivariate logistic regression. RESULTS: Out of 793 children, 186 were diagnosed with MIH (23.5%) with its prevalence reported to be more in boys (102, 54.8%) in comparison to girls (84, 45.2%). The most commonly affected tooth was the mandibular left first permanent molar (22.4%). There was a statistically significant difference reported between gender (p=0.03) and maxillary and mandibular molars (p=0.02), whereas there was no significant difference among MIH involvement on the site (right and left). CONCLUSION: As per the data suggested by the present study, it is important that students be screened regularly for the same so that they can be provided early and prompt treatment.

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Prevalence of Molar Incisor Hypomineralization among School Children Aged 9 to 12 Years in Virajpet, Karnataka, India

Cited by 11 publications

References 20 publications

Gene-environment interaction in molar-incisor hypomineralization

Gene-environment interaction in molar-incisor hypomineralization

Prevalence and Possible Etiological Factors of Molar-Incisor Hypomineralization (MIH) in Population of Silesian Children in Poland: A Pilot Retrospective Cohort Study

Assessing the Prevalence of Molar-Incisor Hypomineralisation among School Children in a North Indian District

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