Prevalence of MR imaging abnormalities in vitamin B12 deficiency patients presenting with clinical features of subacute combined degeneration of the spinal cord

Jain, Krishan K.; Malhotra, Hardeep Singh; Garg, Richa; Gupta, Pradeep Kumar; Roy, Bhaswati; Gupta, Rakesh K.

doi:10.1016/j.jns.2014.05.020

Cited by 55 publications

(69 citation statements)

References 17 publications

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“…This was consistent with the findings of other studies [19, 20]. The posterior column is more vulnerable.…”

Section: Discussionsupporting

confidence: 94%

“…Our MRI studies had a sensitivity of 44.1%. This is higher than the 14.8% (Jain et al [19]), 22.2% (Hemmer et al [11]), and 26.1% (Li et al [2]) sensitivities reported in some previous studies, but lower than the 52.8% sensitivity reported by Xiao et al [22] The following reasons may explain the low detection rate. First, the current approach may not be able to detect micro-lesions of the spinal cord.…”

Section: Discussioncontrasting

confidence: 55%

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Subacute Combined Degeneration: A Retrospective Study of 68 Cases with Short-Term Follow-Up

Cao

et al. 2018

Eur Neurol

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Purpose: The study aimed to analyze the clinical characteristics, laboratory test results, neuroimaging findings, and outcomes in patients diagnosed with subacute combined degeneration (SCD). Materials and Methods: A total of 68 patients with SCD who had been appropriately treated for no less than 6 months were included in our study. Histories, results of routine blood tests, biochemical indices, serum vitamin B₁₂ levels, and spinal magnetic resonance imaging (MRI) findings from the patients were studied and analyzed. Clinical signs and symptoms, graded using a functional disability rating scale, were scored at the time of admission and 3 and 6 months after admission. Results: Limb numbness, limb weakness, and gait disturbances were the most common symptoms in patients with SCD. All patients showed clinical improvement to different degrees at the follow-up visits after vitamin B₁₂ treatment. No differences in rating score were found in patients grouped by sex, hemoglobin level, serum vitamin B₁₂, or MRI manifestations at the time of admission or at the follow-up visits. Younger patients and those with shorter disease courses had better rating scores at the short-term follow-up visits. Conclusion: Anemia, low levels of serum vitamin B₁₂, and MRI abnormalities in the spinal cord are not expected to be associated with worse clinical manifestations. The age of onset and course of disease are important in evaluating the short-term prognosis of patients with SCD.

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“…This was consistent with the findings of other studies [19, 20]. The posterior column is more vulnerable.…”

Section: Discussionsupporting

confidence: 94%

Section: Discussioncontrasting

confidence: 55%

Subacute Combined Degeneration: A Retrospective Study of 68 Cases with Short-Term Follow-Up

Cao

et al. 2018

Eur Neurol

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“…B12 vitamin yetmezliğine bağlı gelişen subakut kombine dejenerasyonun klinik prezentasyonu dorsal ve lateral spinal kord tutulumu sonucu ortaya çıkar (4) . Hastalığın erken dönemlerinde genellikle eller ve ayaklarda parestezi,uyuşukluk, halsizlik görülür.…”

Section: Discussionunclassified

“…Erken dönemde tanı konulup tedavi uygulanabilen durumlarda klinik ve radyolojik bulgularda tama yakın düzelme görülebilmektedir (8) . Vitamin B12 eksikliğinde spinal kord tutulumu, sıklıkla posterior ve lateral kolonlarda görülmekle birlikte ender olarak spinal kordun anterior bölgesinde de görülebilir (4,9) . …”

Section: Discussionunclassified

A Case Of Subacute Combined Degeneration: Atypical İnvolvement Of Anterior Columns

Özkan¹,

Gulluoglu²,

Karaman³

et al. 2016

Okmeydani Medical Journal

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“…5 Cervical and upper thoracic cord are most commonly and severely affected as a continuous long segment. 2,4,6,7 Mild cord expansion and contrast enhancement may be seen. 8 Spinal cord lesions may resolve after appropriate therapy, however cord atrophy develops in some patients.…”

Section: Pathology Findingsmentioning

confidence: 99%

Toxic and Metabolic Myelopathies

Ramalho

Nunes

Rocha

et al. 2016

Seminars in Ultrasound, CT and MRI

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Myelopathy describes any neurologic deficit related to the spinal cord. It is most commonly caused by its compression by neoplasms, degenerative disc disease, trauma, or infection. Less common causes of myelopathy include spinal cord tumors, infection, inflammatory, neurodegenerative, vascular, toxic, and metabolic disorders. Conditions affecting the spinal cord must be recognized as early as possible to prevent progression that may lead to permanent disability. Biopsy is rarely performed, thus the diagnosis and management rely on patient's history, physical examination, laboratory results, and imaging findings. Here we review the clinical presentations, pathophysiological mechanisms, and magnetic resonance imaging findings of myelopathies related to metabolic or toxic etiologies. Semin Ultrasound CT MRI 37:448-465 C 2016 Elsevier Inc. All rights reserved.

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Prevalence of MR imaging abnormalities in vitamin B12 deficiency patients presenting with clinical features of subacute combined degeneration of the spinal cord

Cited by 55 publications

References 17 publications

Subacute Combined Degeneration: A Retrospective Study of 68 Cases with Short-Term Follow-Up

Subacute Combined Degeneration: A Retrospective Study of 68 Cases with Short-Term Follow-Up

A Case Of Subacute Combined Degeneration: Atypical İnvolvement Of Anterior Columns

Toxic and Metabolic Myelopathies

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