Prevalence of MRSA in Clinical Samples and their Antibiotic Sensitivity Pattern

Sathish, J.V.; Wadekar, Mita D.

doi:10.20546/ijcmas.2017.607.334

Cited by 5 publications

(10 citation statements)

References 18 publications

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“…In the antibiotic susceptibility report of Vitek 2 automated system for the MRSA strains in the present study, maximum sensitivity was seen with Linezolid and Vancomycin (100%), followed by Teicoplanin (92%). This is similar to studies conducted by Mita et al 1 , Reema et al 9 and Kumari et al 13 So our study highlights that same drugs appears to be the most effective therapeutic options for treating infections caused by MRSA strains.…”

Section: Discussionsupporting

confidence: 92%

“…They play a major role in several infectious diseases ranging from mild skin and soft tissue infections to serious ailments like bacteremia, endocarditis and many more. 1 S. aureus is the commonest bacterial agent causing illnesses which may be acquired in the community or after hospitalization which readily acquire resistance to multiple antibiotics. 2 In the year 1960's, soon after the introduction of methicillin in clinical world mainly for treating penicillinase producing S.aureus infections, methicillin resistant Staphylococcus aureus (MRSA) emerged and spread worldwide.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Vancomycin Minimum Inhibitory Concentration in the clinical isolates of Methicillin Resistant Staphylococcus aureus (MRSA)

Anitha¹,

Rao²,

Shankaregowda³

et al. 2019

J Pure Appl Microbiol

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Staphylococcus aureus (S.aureus) and coagulase negative Staphylococci (CONS) are the commonest pathogens that lead to severe bacterial infections. It is a bacterium with consistent resistance development against commonly used antibiotics, with emergence of Methicillin resistant staphylococcus aureus (MRSA) causing several infections in patients following hospitalization. Glycopeptides like vancomycin is used as primary drug for treating infectious diseases caused by MRSA. Due to indiscriminate use of vancomycin to treat MRSA, several strains with variable susceptibility to the same have emerged. Evaluation of Vancomycin Minimum Inhibitory Concentration (MIC) in the MRSA isolates obtained from clinical samples received in the diagnostic microbiology laboratory. About 120 Staphylococci obtained from different clinical samples in the diagnostic Microbiology laboratory, at tertiary health care center, South India, were included in the study. The isolates were identified and susceptibility to the relevant antibiotics was done by Vitek 2 an automated system. Vancomycin MIC was detected by Vitek 2 and E-test strip technique. Out of 120 Staphylococcal strains, 79(65.8%) S. aureus and 41(34.1%) CONS were isolated. Methicillin resistance was observed in 38 (48.1%) strains of S. aureus. Almost all 38 MRSA isolates were vancomycin sensitive with MIC range of 0.5-2µg/ml. Maximum isolates had MIC of 1 µg/ml i.e. 65.78% and 71% by E-Test and Vitek 2 respectively. The reported increased MIC of Vancomycin, though within the susceptible range, might experience poor clinical outcomes. Emergence and spread of resistance to glycopeptides like vancomycin needs to be kept in check by rapidly detecting the strains for resistance and strictly obeying the infection control practices.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Evaluation of Vancomycin Minimum Inhibitory Concentration in the clinical isolates of Methicillin Resistant Staphylococcus aureus (MRSA)

Anitha¹,

Rao²,

Shankaregowda³

et al. 2019

J Pure Appl Microbiol

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“…21.4% High level Gentamicin resistance (HLAR) of Eneterococci was detected in our study, similar resistance rate was reported by Anuradha S. De et al, (2015). More than 50% resistance with gentamicin was reported by Butch et al, (2011) andNepal et al, (2013 et al, (2013) and Sathish et al, (2017). S. aureus isolates exhibited 100% sensitivity with vancomycin and linezolid which is similar to study done by Abbas et al, (2015).…”

Section: Antimicrobial Susceptibility In Eskape Pathogenssupporting

confidence: 79%

Clinical Importance of Emerging ESKAPE Pathogens and Antimicrobial Susceptibility Profile from a Tertiary Care Centre

Devi¹,

Saipriya²,

S.³

et al. 2018

Int.J.Curr.Microbiol.App.Sci

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“…Staphylococcus aureus (S. aureus) is a gram positive coagulase positive coccus in the family of staphylococeae [1] and a usual resident of human skin and mucous membrane [2]. This organism have been widely reported as a causative agent of infections such as bacteremia, endocardiatis, urinary tract infection (UTIs) and soft tissue infections [3][4]; both in hospital and community settings.…”

Section: Introductionmentioning

confidence: 99%

“…The first methicilin resistant S. aureus (MRSA) was detected in the early 1960 [2][3]. Methicillin resistant Staphylococcus aureus is resistant to a wide group of antibiotics known as the β-lactams including penicillin and cephalosporins [5].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial resistance profile and molecular detection of MecA gene in methicillin resistant Staphylococcus aureus from patients in selected general hospitals in Abuja municipal, Nigeria

Odogwu¹,

Parom²,

Jodi³

et al. 2019

GSC Biol. and Pharm. Sci.

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Staphylococcus aureus (S. aureus) is globally recognized as an important pathogen associated with both hospital and community acquired infections. Studies on antibiotic resistance profile of S. aureus and carriage of mecA gene in methicillin resistant isolates from patients attending selected general hospitals in Abuja Municipal, Nigeria was carried out. Three hundred and sixty (360) clinical samples (200 urine, 50 high vaginal swabs, 60 ear swab and 40 wound swabs) were collected from Asokoro General Hospital (AGH), Garki Hospital Abuja (GHA) and Wuse General Hospital (WGH); and S. aureus was isolated and identified using standard microbiological methods. Antibiotic susceptibility testing of the isolates was carried out using disc diffusion method. Molecular detection of mecA gene in methicillin resistant isolates was carried out using the polymerase chain reaction method. The total occurrence of S. aureuswas 15.3% (55/360); and the occurrence in relation to the selected hospitals was high in GHA (22.7%) and low in AGH (10.3%). The occurrence of S. aureus was highest in wound swabs in all the hospitals in the order: GHA (47.1%) > AGH (40%) > WGH (35.7%). The isolates from all the hospitals were highly (≥ 50.0%) resistant to all the antibiotics tested; but moderately (≤ 40.0%) to gentamicin and levofloxacin. The occurrence of multi-drug resistant (MDR) isolates in the selected hospitals was high in GHA (27%) but low in AGH (12%). Of the 32 oxacillin resistant isolates, mecA gene was detected in 30 (93.8%). The S. aureus isolates were less resistant to gentamicin and levofloxacin and most of the oxacillin resistant isolates harbored mecA gene.

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Prevalence of MRSA in Clinical Samples and their Antibiotic Sensitivity Pattern

Cited by 5 publications

References 18 publications

Evaluation of Vancomycin Minimum Inhibitory Concentration in the clinical isolates of Methicillin Resistant Staphylococcus aureus (MRSA)

Evaluation of Vancomycin Minimum Inhibitory Concentration in the clinical isolates of Methicillin Resistant Staphylococcus aureus (MRSA)

Clinical Importance of Emerging ESKAPE Pathogens and Antimicrobial Susceptibility Profile from a Tertiary Care Centre

Antimicrobial resistance profile and molecular detection of MecA gene in methicillin resistant Staphylococcus aureus from patients in selected general hospitals in Abuja municipal, Nigeria

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