Prevalence of Multidrug and Extensively Drug-Resistant Tuberculosis in Beijing, China: a Hospital-Based Retrospective Study

Wang, Di; Yang, Caie; Tie-ji, Kuang; Hong, Lei; Meng, Xia; Tong, Aihua; He, Jian‐Qing; Jiang, Ying; Ming, Dong

doi:10.7883/yoken.63.368

Cited by 23 publications

(3 citation statements)

References 6 publications

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“…In addition, efficacy of 4 , 5 , 7 , 10 , and 15 against 10 clinical MTB strains isolated from the Chinese People’s Liberation Army (PLA) 309 hospital were further determined (Table ). As expected, they exhibited equivalent or comparative activity against MDR and XDR isolates compared with that against the susceptible strains.…”

Section: Resultsmentioning

confidence: 99%

“…Measurement of in Vitro Antimycobacterial Activity against MTB. The active compounds were subsequently tested for their efficacy against standard MTB strain H37Rv (Table 3 and 4 In addition, efficacy of 4, 5, 7, 10, and 15 against 10 clinical MTB strains isolated from the Chinese People's Liberation Army (PLA) 309 hospital 28 were further determined (Table 5). As expected, they exhibited equivalent or comparative activity against MDR and XDR isolates compared with that against the susceptible strains.…”

Section: ■ Resultsmentioning

confidence: 99%

“…Standard MTB strain H37Rv (ATCC 27294), which is susceptible to all the anti-MTB drugs, was purchased from Beijing Institute for Tuberculosis Control. Ten clinical isolates, which were identified and characterized for their susceptibility to the first line and second line antibiotics by our team from the PLA 309 hospital, 28 were randomly selected in this work and numbered from A to J. All the isolates were cultured by Lowenstein−Jensen (LJ) medium before used.…”

Section: Journal Of Chemical Information and Modelingmentioning

confidence: 99%

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Discovery of Novel Acetohydroxyacid Synthase Inhibitors as Active Agents againstMycobacterium tuberculosisby Virtual Screening and Bioassay

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Acetohydroxyacid synthase (AHAS) has been regarded as a promising drug target against Mycobacterium tuberculosis (MTB) as it catalyzes the biosynthesis of branched-chain amino acids. In this study, 23 novel AHAS inhibitors were identified through molecular docking followed by similarity search. The determined IC(50) values range from 0.385 ± 0.026 μM to >200 μM against bacterium AHAS. Five of the identified compounds show significant in vitro activity against H37Rv strains (MICs in the range of 2.5-80 mg/L) and clinical MTB strains, including MDR and XDR isolates. More impressively, compounds 5 and 7 can enhance the killing ability against macrophages infected pathogen remarkably. This study suggests our discovered inhibitors can be further developed as novel anti-MTB therapeutics targeting AHAS.

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Section: Resultsmentioning

confidence: 99%

Section: ■ Resultsmentioning

confidence: 99%

Section: Journal Of Chemical Information and Modelingmentioning

confidence: 99%

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Discovery of Novel Acetohydroxyacid Synthase Inhibitors as Active Agents againstMycobacterium tuberculosisby Virtual Screening and Bioassay

Wang

Zhu

Cui

et al. 2013

J. Chem. Inf. Model.

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Multidrug-Resistant Tuberculosis: A Global Challenge

Fong

2012

Challenges in Infectious Diseases

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Characterization of Th1- and Th2-type immune response in human multidrug-resistant tuberculosis

Tan

Xie

Min

et al. 2011

Eur J Clin Microbiol Infect Dis

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Multidrug-resistant tuberculosis (MDR-TB) has become a lethal global threat. Insights into the immune regulation of MDR-TB are urgently needed for the development of new treatments; however, the T cell response to an MDR-TB infection in human remains unclear. In the present study, the proportion of Th1 and Th2 cell subsets and the level of related T cell subset cytokines in peripheral blood were investigated. We detected that an MDR-TB infection resulted in suppressed Th1 and Th2 cell activation, which was more remarkable in patients with MDR-TB than that in drug-sensitive tuberculosis (DS-TB) sufferers when compared to healthy controls (HCs). In addition, MDR-TB infection down-regulated the expression of IFN-γ, IL-2, and IL-10, and up-regulated IL-4, IL-6, and TNF-α expression. Our data suggest that the disturbance between protective and pathogenic effects induced by the immunosuppression of Th1- and Th2-type responses is a substantial characteristic of MDR-TB infections.

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Prevalence of Multidrug and Extensively Drug-Resistant Tuberculosis in Beijing, China: a Hospital-Based Retrospective Study

Cited by 23 publications

References 6 publications

Discovery of Novel Acetohydroxyacid Synthase Inhibitors as Active Agents againstMycobacterium tuberculosisby Virtual Screening and Bioassay

Discovery of Novel Acetohydroxyacid Synthase Inhibitors as Active Agents againstMycobacterium tuberculosisby Virtual Screening and Bioassay

Multidrug-Resistant Tuberculosis: A Global Challenge

Characterization of Th1- and Th2-type immune response in human multidrug-resistant tuberculosis

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