Prevalence of Multidrug Resistance (MDR) Klebsiella Species in Ventilated Associated Pneumonia (VAP), Urine Tract Infection (UTI) and in Wound Cases

Abstract

Objective: To report trends of extended spectrum β-lactamase (ESBL), multidrug resistant (MDR) ESBL and AmpC producing isolates of K. pneumoniae from MGM Hospital, kamothe. Navi Mumbai. Methods: Multidrug resistance, ESBL & AmpC production was tested by confirmatory methods as per Clinical Laboratory Standard Institute (CLSI) guidelines. Results:-Out of 1670 sample (urine, pus and ET-secretion) 89(5.32%) klebsiella strain were isolated among them 57(64%) were MDR strains resistance to ceftizoxime 80%, cefuroxime 80%, tetracycline 78%, cefaperazone 75%,ceftazidime 70%. Among these isolates higher prevalence of ESBL and AmpC production was observed in ET-secretion 46.66% and 20% followed by urine 35% and 11.7% and pus 32%.and 8%. Conclusion:-Detection for the ESBL and AmpC should be carried out as a routine it is simple and cost effective test to improve infections control practices to avoid irrational use of antibiotics and empirical regime should be revisited to prevent further resistance