ObjectiveThis study aimed to assess the prevalence of low back pain and associated factors among professional taxi drivers.DesignCommunity-based cross-sectional study.Setting and participantsA Modified Nordic Musculoskeletal Questionnaire was used to collect data. Through a simple random sampling technique, 371 taxi drivers were selected in Gondar City, Ethiopia.Data analysisSPSS V.22 was used for data analysis. Bivariable and multivariable logistic regression analyses were used to identify the factors associated with low back pain. A p value less than 0.05 and an adjusted odds ratio (AOR) with 95% CI were used to declare statistical significance.ResultA total of 371 respondents, with a response rate of 95.4%, have participated. The past 1 year and week’s prevalence of low back pain among taxi drivers was 85.7% (95% CI 82.5 to 89.2) and 53.4% (95% Cl 48.0 to 58.5), respectively. Overweight/obese (AOR=0.33, 95% CI (0.14 to 0.80)), alcohol drinking (AOR=4.77, 95% CI (1.16 to 19.5)), job dissatisfaction (AOR=4.58, 95% CI (1.39 to 15.2)), prolonged working hours per day (AOR=2.64; 95% CI (1.02 to 6.08)), not using the adjustable seat with back support (AOR=6.38, 95% CI (2.39 to 17.01)) were associated with low back pain among taxi drivers.ConclusionThe prevalence of low back pain among taxi drivers was high. Being overweight/obese, alcohol drinking, job dissatisfaction, prolonged working hours per day, and not using adjustable seats with back support, were factors associated with low back pain among taxi drivers. Therefore, ergonomic and behavioural-related awareness training is recommended to minimise the burden of low back pain among taxi drivers.