Prevalence of Mycoplasma pneumoniae Infection in Malagasy Children

Ravelomanana, Lova; Bouazza, Naïm; Rakotomahefa, Mbola; Andrianirina, André Zo; Robinson, Annick; Raobidjaona, Honoré; Andriamihaja, R.; Benhaddou, Nadjet; Randrianirina, Frédérique; Ratsima, Elisoa; Imbert, Patrick; Raymond, Josette

doi:10.1097/inf.0000000000001471

Cited by 11 publications

(7 citation statements)

References 37 publications

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“…Bacterial and viral infections are the most common reasons that children receive medical care in clinics or small hospitals [ 1 , 2 ]. Because the symptoms exhibited by patients with bacterial and viral infections are similar, symptom-based examinations and history-taking are usually insufficient to distinguish between bacterial and viral infections, even by experienced doctors [ 3 ].…”

Section: Assessing Infectious Disease Among Children: the Need For Immentioning

confidence: 99%

Differential Markers of Bacterial and Viral Infections in Children for Point-of-Care Testing

Tsao

Tsai

Liao

et al. 2020

Trends in Molecular Medicine

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Children suffering from infectious diseases, both bacterial and viral, are often treated with empirical antibiotics. Keeping in mind both the menace of microorganisms and antibiotic toxicity, it is imperative to develop point-of-care testing (POCT) to discriminate bacterial from viral infections, and to define indications for antibiotic treatment. This article reviews potential protein biomarkers and host-derived gene expression signatures for differentiating between bacterial and viral infections in children, and focuses on emerging multiplex POCT devices for the simultaneous detection of sets of protein biomarkers or streamlined gene expression signatures that may provide rapid and cost-effective pathogen-discriminating tools.

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Section: Assessing Infectious Disease Among Children: the Need For Immentioning

confidence: 99%

Differential Markers of Bacterial and Viral Infections in Children for Point-of-Care Testing

Tsao

Tsai

Liao

et al. 2020

Trends in Molecular Medicine

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“…None of the clinical signs evaluated in this study showed statistically significant associations with M. pneumoniae . Other studies found no relationship between clinical presentation and CAP due to M. pneumoniae 42,54. These findings show that the diagnosis of CAP due to M. pneumoniae can rarely be established based on the clinical presentation alone.…”

Section: Discussionmentioning

confidence: 63%

<p>Detection of <em>Mycoplasma pneumoniae</em> in Mexican children with community-acquired pneumonia: experience in a tertiary care hospital</p>

Mérida-Vieyra

Aquino-Andrade²,

Palacios-Reyes³

et al. 2019

IDR

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Purpose: Mycoplasma pneumoniae is an important cause of community-acquired pneumonia (CAP). Information on the prevalence of M. pneumoniae in pediatric patients with CAP in Mexico is limited. The aim of this study was to detect M. pneumoniae in hospitalized pediatric patients with CAP. Patients and methods: We performed a descriptive study in a tertiary-level pediatric reference center, obtaining 154 respiratory samples from patients under 18 years of age and diagnosed with CAP. M. pneumoniae was detected by real-time polymerase chain reaction (PCR) targeting the p1 and CARDS genes. Complete blood cell count, measurement of C-reactive protein and detection of IgM and IgG anti-P1 were performed. Clinical, epidemiological and radiological data of the patients were analyzed. Results: M. pneumoniae was detected by real-time PCR in 26.6% of the samples. 39% of the cases occurred during the spring season. A total of 83% of the patients with M. pneumoniae had some underlying disease; renal disease, autoimmune disease and primary immunodeficiencies had a significant association with M. pneumoniae CAP. Children under 6 years of age represented 53.7% of the cases. Fever and cough were the most frequent symptoms. IgM and IgG were positive in 1.9% and 14% of the patients, respectively. In the chest X-ray, 17.1% of the patients showed multifocal alveolar infiltrates pattern. The complications in this series were 26.8%. The mortality in this study was 4.9%. Conclusion: This is the first report in Mexico about M. pneumoniae as a causal agent of CAP in a tertiary care pediatric hospital using real-time PCR and serology. M. pneumoniae was responsible for 26.6% of the cases and was frequent in children under 6 years of age. In addition, we described the clinical presentation in patients with underlying diseases.

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“…In addition, it is a significant cause leading to the hospitalization of children with community‐acquired pneumonia . The incidence of mycoplasma pneumonia in children is high, which accounts for 16%‐30% of community‐acquired pneumonia in children . It is generally mild, but it can be very serious, even involves extra pulmonary spread, such as central nervous system, mucosa and other organs, which seriously endangered the health of children .…”

Section: What Is Known and Objectivementioning

confidence: 99%

“…3,4 The incidence of mycoplasma pneumonia in children is high, which accounts for 16%-30% of communityacquired pneumonia in children. [5][6][7][8] It is generally mild, but it can be very serious, even involves extra pulmonary spread, such as central nervous system, mucosa and other organs, which seriously endangered the health of children. 4 Due to the serious side effects of tetracycline and fluoroquinolones on children, macrolides have become first choice for the treatment of mycoplasma pneumonia in children.…”

Section: What Is K Nown and Objec Tivementioning

confidence: 99%

Comparative efficacy of Chinese herbal injections combined with azithromycin for mycoplasma pneumonia in children: A Bayesian network meta‐analysis of randomized controlled trials

Duan

Wang

et al. 2019

J Clin Pharm Ther

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What is known and objectiveAn increasing macrolide resistance leads to complex clinical treatment schemes in mycoplasma pneumonia in children. Chinese herbal injection (CHI) is widely used to treat it and may provide a new treatment regimen. This study was conducted to systematically evaluate the efficacy of CHIs combined with azithromycin for treating mycoplasma pneumonia in children by Bayesian network meta‐analysis.MethodsRandomized controlled trials (RCTs) of CHIs combined with azithromycin for mycoplasma pneumonia in children were searched in electronic databases and related references from initiation to 30 October 2018. Two researchers conducted data extraction and risk of bias assessment. WinBUGS software and STATA software were adopted to analyse the data.ResultsA total of 167 RCTs were included with 5 CHIs involving 16 144 patients. All CHIs combined with azithromycin had superior effects than azithromycin only among overall outcomes. Yanhuning injection combined with azithromycin ranked highest in four different outcomes and second in two based on surface under the cumulative ranking probabilities (SUCRA). Meanwhile, the results of MD and 95% CIs of concerned outcomes indicated that only Yanhuning injection combined with azithromycin had better response than other CHIs combined with azithromycin. Moreover, cluster analysis results revealed Reduning injection combined with azithromycin was associated with a positive effect on the three group outcomes. Similarly, it was found to be the top three ranking in all outcomes based on SUCRA.What is new and conclusionYanhuning injection combined with azithromycin and Reduning injection combined with azithromycin were found to be preferable treatments based on the data of this study.

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Prevalence of Mycoplasma pneumoniae Infection in Malagasy Children

Abstract: We report a prevalence of 18.2% for M. pneumoniae infection in children in Madagascar. The prevalence of M. pneumoniae infection was higher in the control patients than in asthmatic ones.

Cited by 11 publications

References 37 publications

Differential Markers of Bacterial and Viral Infections in Children for Point-of-Care Testing

Differential Markers of Bacterial and Viral Infections in Children for Point-of-Care Testing

<p>Detection of <em>Mycoplasma pneumoniae</em> in Mexican children with community-acquired pneumonia: experience in a tertiary care hospital</p>

Comparative efficacy of Chinese herbal injections combined with azithromycin for mycoplasma pneumonia in children: A Bayesian network meta‐analysis of randomized controlled trials

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