Prevalence of Myocardial Infarction in Patients With Chronic Pancreatitis

Khan, Danyal; Abureesh, Mohammad; Alkhayyat, Motasem; Sadiq, Waleed; Alshami, Mohammad; Munir, Abdullah B.; Karam, Boutros; Deeb, Liliane; Lafferty, James

doi:10.1097/mpa.0000000000001721

Cited by 8 publications

(6 citation statements)

References 26 publications

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“…In fact, risk of CVD was higher in patients with CP (adjusted HR, 3.42) than those with AP (adjusted HR, 1.76) in the aforementioned study 5 . Increased risk of CVD in patients with CP were also reported in other studies, with a range of 1.27–1.453 25 – 27 . However, caution is needed in interpreting the results due to the heterogeneity of CP patients.…”

Section: Discussionsupporting

confidence: 77%

Risk of cardiovascular disease and mortality in patients with diabetes and acute pancreatitis history: a nationwide cohort study

Jang

Choi

Paik

et al. 2022

Sci Rep

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Patients with acute pancreatitis (AP) may have an increased risk of cardiovascular disease (CVD). Few studies have dealt with the association between AP and the risk of CVD in diabetic patients. This study aimed to investigate the risk of CVD and mortality in patients with diabetes and AP history by analyzing a large-scale national claims database in Korea. Data from the Korean National Health Insurance Service database was analyzed. A total of 2,746,988 participants with type 2 diabetes mellitus that underwent a general health examination between 2009 and 2012 were enrolled. The participants were divided into two groups according to AP history (yes or no) prior to the examination date, and follow-up data until 2018 was analyzed. The primary endpoint was the occurrence of stroke, myocardial infarction (MI), or death. The Cox proportional hazards regression analysis was used to evaluate the association between AP history and the risk of stroke, MI, and mortality. After exclusion, the included number of participants with and without AP history were 3,810 and 2,258,910, respectively. The presence of AP history showed a significantly higher incidence of stroke, MI, and mortality. The adjusted hazard ratios (95% confidence interval) for the risk of stroke, MI, and mortality were 1.534 (1.342–1.753), 1.998 (1.733–2.303), and 2.353 (2.200–2.515), respectively. Age < 65, male sex, current smoking, and drinking significantly increased the risk of death in the subgroup analyses. The risk of stroke, MI, and mortality was significantly higher in diabetic participants with AP history than those without AP history at 9-year follow-up. This suggests that active management of cardiovascular risk factors is necessary in diabetic patients with AP history.

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Section: Discussionsupporting

confidence: 77%

Risk of cardiovascular disease and mortality in patients with diabetes and acute pancreatitis history: a nationwide cohort study

Jang

Choi

Paik

et al. 2022

Sci Rep

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“…A recent database analysis reported that the overall prevalence of myocardial infarction was 14.22% in CP patients as compared with 3.23% in controls, although data regarding ASCVD risk in CP patients are still scarce. 34 In our analysis, we found that CP patients had a higher risk of ischemic heart disease, including acute coronary syndrome, heart failure, and cardiac arrest, compared with propensity-matched controls.…”

Section: Discussionmentioning

confidence: 63%

Chronic Pancreatitis and Risk of Atherosclerotic Cardiovascular Disease

et al. 2023

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ObjectivesWorldwide prevalence of chronic pancreatitis (CP) has risen in recent years, with data suggesting an increased risk of atherosclerotic cardiovascular disease (ASCVD) in these patients. We assessed the incidence and risk of ASCVD in patients with CP.MethodsWe compared the risk of ischemic heart disease, cerebrovascular accident, and peripheral arterial disease between CP and non-CP cohorts after propensity matching of known risk factors of ASCVD using TriNetX, a multi-institutional database. We also evaluated the risk of outcomes of ischemic heart disease including acute coronary syndrome, heart failure, cardiac arrest, and all-cause mortality between CP and non-CP cohorts.ResultsChronic pancreatitis cohort was also found to have an increased risk of ischemic heart disease (adjusted odds ratio [aOR], 1.08; 95% confidence interval [CI], 1.03–1.12), cerebrovascular accident (aOR, 1.12; 95% CI, 1.05–1.20), and peripheral arterial disease (aOR, 1.17; 95% CI, 1.1–1.24). Chronic pancreatitis patients with ischemic heart disease were also found to have an increased risk of acute coronary syndrome (aOR, 1.16; 95% CI, 1.04–1.30), cardiac arrest (aOR, 1.24; 95% CI, 1.01–1.53), and mortality (aOR, 1.60; 95% CI, 1.45–1.77).ConclusionsChronic pancreatitis patients are at a higher risk of ASCVD when compared with the general population, matched for confounding etiological, pharmacological, and comorbid variables.

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“…However, it is important to note that, compared to ICD coding, SNOMED-CT allows for more concepts to be coded per clinical document, making it more accurate in terms of documenting diagnoses and pertinent patient information. Moreover, Explorys has been validated and used in multiple specialties, including gastroenterology [ 37 - 39 ]. Despite the aforementioned limitations, it is worth highlighting that this is the largest and one of the few studies to date to evaluate the epidemiology, and risk factors of patients with aNETs in the US population.…”

Section: Discussionmentioning

confidence: 99%

Epidemiology of neuroendocrine tumors of the appendix in the USA: a population-based national study (2014-2019)

Alkhayyat

Saleh

Coronado

et al. 2021

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Background The appendix is the third most common place for neuroendocrine tumors (NETs) along the digestive tract and NETs are the most common neoplasms of the appendix. However, there are limited population-based data on the epidemiology of this disease. Using a large database, we sought to describe the epidemiology and risk association of NETs of the appendix. Method We queried a multi-institutional database (Explorys Inc., Cleveland, OH, USA), comprising 360 hospitals in the United States (US), for patients with a diagnosis of NETs of the appendix from 2014-2019. Results Of the 30,324,050 individuals in the database, 2020 patients had an appendiceal NET diagnosis (0.007%). The most common presenting symptoms included abdominal pain, nausea, vomiting and diarrhea. Patients with appendiceal NETs were more likely to be female (odds ratio [OR] 1.36, 95% confidence interval [CI] 1.24-1.49), Caucasian (OR 2.71, 95%CI 2.40-3.07), with a history of smoking (OR 1.82, 95%CI 1.65-2.01), family history of primary gastrointestinal malignancy (OR 7.26, 95%CI 6.31-8.33), diagnosis of multiple endocrine tumor type 1 (OR 52.31, 95%CI 23.15-118.23), or neurofibromatosis type 1 (OR 16.37, 95%CI 7.24-37.01). Conclusions In a population-based study in the US, using the Explorys database, we found the overall prevalence of NETs of the appendix to be 7 per 100,000 persons. The incidence in the year January 2019-January 2020 was 0.4 per 100,000 individuals. These rates are higher than previously reported and may be more accurate, given the more comprehensive nature of the Explorys database.

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Prevalence of Myocardial Infarction in Patients With Chronic Pancreatitis

Cited by 8 publications

References 26 publications

Risk of cardiovascular disease and mortality in patients with diabetes and acute pancreatitis history: a nationwide cohort study

Risk of cardiovascular disease and mortality in patients with diabetes and acute pancreatitis history: a nationwide cohort study

Chronic Pancreatitis and Risk of Atherosclerotic Cardiovascular Disease

Epidemiology of neuroendocrine tumors of the appendix in the USA: a population-based national study (2014-2019)

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