Prevalence of myocardial infarction polymorphisms in Afyonkarahisar, Western Turkey

Onrat, Serap Tutgun; Akçi, Önder; Söylemez, Zafer; Onrat, Ersel; Avsar, Alaettin

doi:10.1007/s11033-012-1799-1

Cited by 21 publications

(18 citation statements)

References 41 publications

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“…There was one prospective study 6 and 33 cross-sectional case–control studies. Twenty-two studies included Caucasian patients 4 , 6 , 11 , 13 , 14 , 16 , 18 , 20 , 21 , 23 – 27 , 29 , 33 – 39 , 9 included non-Caucasians 8 , 10 , 12 , 15 , 17 , 19 , 28 , 30 , 32 , and 3 did not depict ethnicity of subjects 5 , 22 , 31 . As the study population overlapped in two reports 6 , 39 , Maren’s data 39 were evaluated only in the >55-year-old subgroup analysis and not in the overall analysis.…”

Section: Resultsmentioning

confidence: 99%

“…Allele number, but not genotype frequency, was available in one study 27 , which consequently was included in the allele model analysis only. Because there was only one eligible study 19 of homozygote and recessive models in non-Caucasian subgroup analysis, homozygote and recessive analyses were not performed in the non-Caucasian subgroup.…”

Section: Resultsmentioning

confidence: 99%

“…Substantive studies over the past decade have been making efforts to unmask the correlation between the G20210A SNP and MI. However, previous conflicting reports failed to draw a consistent conclusion, thereby making the association between the G20210A SNP and MI elusive 8 , 10 , 18 , 19 , 25 – 27 , 37 – 39 . The variance may result from different study designs and distinct ethnic backgrounds of subjects.…”

Section: Discussionmentioning

confidence: 96%

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Prothrombin G20210A (rs1799963) polymorphism increases myocardial infarction risk in an age-related manner: A systematic review and meta-analysis

Ren

Chen

et al. 2017

Sci Rep

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G20210A polymorphism (rs1799963) within the prothrombin gene is associated with a higher circulation level of prothrombin, thus increasing the likelihood of developing myocardial infarction (MI). Opinions differ regarding the correlation between prothrombin G20210A genotype and MI risk, which prompted us to conduct a meta-analysis to determine this association. PubMed, EMBASE, Web of Science and CNKI were searched for pertinent reports. A total of 34 studies involving 14 611 MI cases and 84 358 controls were analyzed in this quantitative analysis. We found a statistically significant association between prothrombin G20210A polymorphism and MI in the allele model (A vs. G, OR = 1.43, 95%CI: 1.18–1.72), heterozygote model (GA vs. GG, OR = 1.41, 95%CI: 1.16–1.72) and dominant model (GA + AA vs. GG, OR = 1.41, 95%CI: 1.15–1.72). The association remains significant in Caucasians but not in non-Caucasians. Moreover, prothrombin G20210A polymorphism increases MI risk in an age-related manner. A further significant association was found in a subpopulation younger than 55 years (allele model, OR = 1.76, 95%CI: 1.32–2.35; heterozygote model, OR = 1.70, 95%CI: 1.24–2.33; dominant model, OR = 1.70, 95%CI: 1.24–2.34). Sensitivity analysis and publication bias analysis revealed stable and statistically robust results. Our meta-analysis demonstrated that prothrombin G20210A polymorphism may represent a risk factor for MI.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 96%

See 1 more Smart Citation

Prothrombin G20210A (rs1799963) polymorphism increases myocardial infarction risk in an age-related manner: A systematic review and meta-analysis

Ren

Chen

et al. 2017

Sci Rep

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“…It has been shown that traditional risk factors, including diet, obesity, diabetes, hypertension, dyslipidemia, inflammation, smoking, and alcohol consumption, allow the prediction of only about 50% of the absolute risk of a cardiovascular event in individual patients [6,7], and the remaining risk is attributed to genetic influences [8]. Genetic susceptibility may be caused by mutations and polymorphisms in a variety of genes mostly involved in blood coagulation, regulation of blood pressure, and metabolism of glucose, lipids, or homocysteine [7]. …”

Section: Introductionmentioning

confidence: 99%

Common Variants of Vitamin D Receptor Gene Polymorphisms and Susceptibility to Coronary Artery Disease: A Systematic Review and Meta-Analysis

Alizadeh¹,

Djafarian²,

Alizadeh

et al. 2017

Lifestyle Genomics

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Background and Aims:ApaI, FokI, TaqI, and BsmI polymorphisms in the vitamin D receptor (VDR) gene have been reported to be associated with the risk of coronary artery disease (CAD), although the results of previous studies have been inconsistent. The aim of this study was to explore whether these polymorphisms play a role in the genetic susceptibility to CAD. Methods: A comprehensive search of Medline and Embase databases was conducted for studies evaluating the association between the VDR polymorphisms and CAD risk. Odds ratios with 95% confidence intervals were calculated to assess the strength of association in the dominant model, recessive model, allelic model, and genotypes contrast. Results: Nine studies involving a total of 5,259 cases and 1,981 controls were finally included in this meta-analysis. Overall, no significant associations were found between ApaI, FokI, TaqI, and BsmI polymorphisms and the risk of CAD in any of the genetic models (all p ˃ 0.05). Moreover, a subgroup analysis by ethnicity did not reveal a significant relationship between any of the examined polymorphisms and CAD risk in Caucasians and East-Asians for any model (all p ˃ 0.05). Conclusion: Current evidence suggests that the ApaI, FokI, TaqI, and BsmI polymorphisms of the VDR gene might not be associated with genetic susceptibility to CAD. Further well-designed studies with large sample sizes are needed to confirm our results.

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“…Our second case is the first reported neonatal CSVT with homozygotic MTHFR A1298C and PAI 4G/5G polymorphism. Onrat et al 8 also reported that the PAI 4G/5G polymorphism is associated with myocardial infarction in patients before the age of 45.…”

Section: Discussionmentioning

confidence: 96%

Neonatal cerebral sinovenous thrombosis: Two cases, two different gene polymorphisms and risk factors

Turan¹,

Ince²,

Olcay³

et al. 2017

Turk J Pediatr

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Prevalence of myocardial infarction polymorphisms in Afyonkarahisar, Western Turkey

Cited by 21 publications

References 41 publications

Prothrombin G20210A (rs1799963) polymorphism increases myocardial infarction risk in an age-related manner: A systematic review and meta-analysis

Prothrombin G20210A (rs1799963) polymorphism increases myocardial infarction risk in an age-related manner: A systematic review and meta-analysis

Common Variants of Vitamin D Receptor Gene Polymorphisms and Susceptibility to Coronary Artery Disease: A Systematic Review and Meta-Analysis

Neonatal cerebral sinovenous thrombosis: Two cases, two different gene polymorphisms and risk factors

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