Prevalence of myopic macular degeneration worldwide: a systematic review and meta-analysis

Zou, Minjie; Wang, Shibin; Chen, Aiming; Liu, Zhenzhen; Young, Charlotte Aimee; Zhang, Yichi; Jin, Guangming; Zheng, Danying

doi:10.1136/bjophthalmol-2019-315298

Cited by 32 publications

(30 citation statements)

References 29 publications

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“…Recently, a meta‐analysis revealed that females had a higher risk of myopic macular degeneration than males (Zou et al. 2020). However, its internal mechanism remains unclear.…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of fundus tessellation and its associated factors in Chinese children and adolescents with high myopia

Cheng

Deng

et al. 2021

Acta Ophthalmologica

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Purpose: To investigate the prevalence and associated factors of fundus tessellation in highly myopic children and adolescents. Methods: A total of 513 high myopes (spherical equivalent [SE] ≤ À5.0 D, 4-19 years of age) without any advanced pathological myopic lesions were enrolled. Fundus photographs and choroidal thickness (ChT) data were collected by SS-OCT. A novel grading approach was adopted to classify fundus tessellation into four categories on colour fundus photography, referring to the location of tessellation divided by an Early Treatment Diabetic Retinopathy Study grid centred on the fovea, through which closer to the fovea represents higher grades of fundus tessellation. Peripapillary atrophy (PPA) area and ovality index were also measured. Results: Among the participants, with a mean age of 13.47 AE 3.13 years and mean SE of À 8.34 AE 1.91 D, there were 29 (5.7%), 95 (18.5%), 233 (45.4%) and 156 (30.4%) participants with grade 0 to grade 3 fundus tessellation, respectively. The ChT in both the macular and peripapillary area was negatively correlated with the fundus tessellation grade (R = À0.763 and À0.537, respectively, all p < 0.001). Higher grades of fundus tessellation were independently associated with thinner macular ChT (

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“…Recently, a meta‐analysis revealed that females had a higher risk of myopic macular degeneration than males (Zou et al. 2020). However, its internal mechanism remains unclear.…”

Section: Discussionmentioning

confidence: 99%

“…The female sex has also been reported to increase the risk of myopic maculopathy progression (Fang et al 2018). Recently, a metaanalysis revealed that females had a higher risk of myopic macular degeneration than males (Zou et al 2020). However, its internal mechanism remains unclear.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of fundus tessellation and its associated factors in Chinese children and adolescents with high myopia

Cheng

Deng

et al. 2021

Acta Ophthalmologica

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“…38,39 Of these, myopic retinopathy or MMD is fast emerging as one of the leading causes of blindness in East Asia and else-where. 15,17,40 A recent meta-analysis found a pooled prevalence of MMD in the world population of 2.1% (increasing from 1.3% in the 40-49 age group to 4.5% in the 70+ age group) 41 and found a higher frequency of MMD from data reported from 2007 to 2019 compared to 1993 to 2006. Vision impairment from MMD was estimated to have affected 10 million people (0.13% of world's population) in 2015 and, if the trajectory for the rising prevalence of myopia and high myopia continues at the same pace, it is set to grow to nearly 56 million (0.6%) by the year 2050.…”

Section: Life-course Of Myopiamentioning

confidence: 99%

IMI Impact of Myopia

Sankaridurg

Tahhan

Kandel

et al. 2021

Invest. Ophthalmol. Vis. Sci.

212

141

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The global burden of myopia is growing. Myopia affected nearly 30% of the world population in 2020 and this number is expected to rise to 50% by 2050. This review aims to analyze the impact of myopia on individuals and society; summarizing the evidence for recent research on the prevalence of myopia and high myopia, lifetime pathological manifestations of myopia, direct health expenditure, and indirect costs such as lost productivity and reduced quality of life (QOL). The principal trends are a rising prevalence of myopia and high myopia, with a disproportionately greater increase in the prevalence of high myopia. This forecasts a future increase in vision loss due to uncorrected myopia as well as high myopia-related complications such as myopic macular degeneration. QOL is affected for those with uncorrected myopia, high myopia, or complications of high myopia. Overall the current global cost estimates related to direct health expenditure and lost productivity are in the billions. Health expenditure is greater in adults, reflecting the added costs due to myopia-related complications. Unless the current trajectory for the rising prevalence of myopia and high myopia change, the costs will continue to grow. The past few decades have seen the emergence of several novel approaches to prevent and slow myopia. Further work is needed to understand the life-long impact of myopia on an individual and the cost-effectiveness of the various novel approaches in reducing the burden.

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“…Amid the different conditions that can deteriorate the status of the macula, two are the conditions that appear more often: the myopic macular degeneration, which occurs in the presence of high myopia [1], and the age-related macular degeneration (AMD), which usually appears in the last decades of life [2]. Myopic macular degeneration and AMD combined affect approximately 11% of the world's population [1,3].…”

Section: Introductionmentioning

confidence: 99%

Target Maintenance in Gaming via Saliency Augmentation: An Early-Stage Scotoma Simulation Study Using Virtual Reality (VR)

2021

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This study addresses the importance of salience placement before or after scotoma development for an efficient target allocation in the visual field. Pre-allocation of attention is a mechanism known to induce a better gaze positioning towards the target. Three different conditions were tested: a simulated central scotoma, a salience augmentation surrounding the scotoma and a baseline condition without any simulation. All conditions were investigated within a virtual reality VR gaming environment. Participants were tested in two different orders, either the salient cue was applied together with the scotoma before being presented with the scotoma alone or the scotoma in the wild was presented before and, then, with the augmentation around it. Both groups showed a change in gaze behaviour when saliency was applied. However, in the second group, salient augmentation also induced changes in gaze behaviour for the scotoma condition without augmentation, gazing above and outside the scotoma following previous literature. These preliminary results indicate salience placement before developing an advanced stage of scotoma can induce effective and rapid training for efficient target maintenance during VR gaming. The study shows the potential of salience and VR gaming as therapy for early AMD patients.

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Prevalence of myopic macular degeneration worldwide: a systematic review and meta-analysis

Cited by 32 publications

References 29 publications

Prevalence of fundus tessellation and its associated factors in Chinese children and adolescents with high myopia

Prevalence of fundus tessellation and its associated factors in Chinese children and adolescents with high myopia

IMI Impact of Myopia

Target Maintenance in Gaming via Saliency Augmentation: An Early-Stage Scotoma Simulation Study Using Virtual Reality (VR)

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