Prevalence of Nasopharyngeal Carcinoma Patients in Departement of Orl-HNS Hasan Sadikin General Hospital 2010 -2017

Handayani, Riri; Dewi, Yussy Afriani; Madani, Deasy Z

doi:10.32734/ijnpc.v2i01.3191

Cited by 8 publications

(11 citation statements)

References 19 publications

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“…It differs from Handayani's (2020) research, where most NPC patients have an elementary school educational background. The patient's educational background and socioeconomic conditions can affect the choice of the patient's medical treatment decisions [15]. Patients may refuse therapy due to a lack of funds or a fear of the treatment's side effects and seek alternative options [16].…”

Section: Discussionmentioning

confidence: 99%

Assessment of Response to Chemoradiation and Radiation Therapy in Patients with Nasopharyngeal Carcinoma

Susanto

Dewi

Saputri

2022

Open Access Maced J Med Sci

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BACKGROUND: Nasopharyngeal carcinoma (NPC) is a head-and-neck cancer that develops in the epithelial lining of the nasopharynx. The provision of radiotherapy and chemoradiation therapy in NPC can be evaluated by assessing the tumor response. AIM: The present study aims to determine the response in patients with nasopharyngeal carcinoma (NPC) to radiotherapy and chemoradiation therapy. METHODOLOGY: The study design is a retrospective bivariate analytic study from the Otorhinolaryngology-Head and Neck Society Head-Neck Surgical Oncology data registry program for the period of 2016−2021 at Dr. Hasan Sadikin General Hospital, Bandung. A total sample of 447 patients with NPC was used, and data were processed with descriptive and bivariate analytical tests. The variables used were patient characteristics and tumor response to radiotherapy and chemoradiation therapy. The tumor response was obtained based on the results of the examination at least 3 months after the administration of therapy and categorized according to the Response Evaluation Criteria in Solid Tumors 1.1 (RECIST 1.1). RESULTS: Three hundred and eighty-three NPC patients (252 men and 131 women) underwent chemoradiation or radiation therapy, and their tumor response had been evaluated. Most patients were diagnosed at Stages III and IV and treated by chemoradiation. In total, 314 of 383 patients (82%) achieved CR (complete response), 50 patients (13.1%) achieved PR (partial response), 11 patients (2.9%) had PD (progressive disease), and 8 (2.1%) patients had SD (stable disease). There is no statistically significant difference in the type of therapy response when correlated with the each of the variables; age, sex, and educational level (p > 0.05). There is a statistically significant difference in the type of therapy response among different clinical stage groups (p < 0.0001). CONCLUSION: Most nasopharyngeal carcinoma patients in the study had a complete response (82%) for either chemoradiation or radiotherapy alone. Age, sex, and education level have no significant effect on therapy response. On the other hand, the response to therapy is significantly correlated to the clinical stage of the disease.

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Section: Discussionmentioning

confidence: 99%

Assessment of Response to Chemoradiation and Radiation Therapy in Patients with Nasopharyngeal Carcinoma

Susanto

Dewi

Saputri

2022

Open Access Maced J Med Sci

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“…14 Angka kejadian karsinoma nasofaring cukup tinggi di Indonesia karena jumlah masyarakat Indonesia yang mengonsumsi ikan asin cukup banyak, sekitar 43% dibandingkan dengan konsumsi makanan yang diawetkan lainnya. 15 Penelitian yang dilakukan Azizah pada tahun 2014 dan Zein pada tahun 2020 menunjukkan bahwasannya konsumsi ikan asin lebih dari tiga kali dalam satu bulan menunjukkan hubungan yang signifikan dengan insiden KNF, 3,25 akan tetapi hal tersebut tidak sesuai dengan penelitian Lau pada tahun 2013 dan Hsu pada tahun 2012 8,13 bahwasannya tidak terdapat hubungan antara konsumsi ikan asin terhadap kanker nasofaring.…”

Section: Pendahuluanunclassified

Konsumsi Ikan Asin Meningkatkan Risiko Kanker Nasofaring: Tinjauan Sistematik dan Meta-analisis

MUNAWIR,

Dika Pangestu,

Indreswari

2023

JOKLI

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Latar Belakang: Kanker nasofaring atau sering disebut sebagai KNF adalah penyakit keganasan sel skuamosa pada lapisan epitel nasofaring. Konsumsi makanan diawetkan menyumbang persentase tertinggi penyebab KNF sebesar 35,5%, salah satu makanan diawetkan adalah ikan asin. Terdapat perbedaan pendapat di antara studi-studi yang ada mengenai pengaruh konsumsi ikan asin terhadap risiko kanker nasofaring. Beberapa studi menunjukkan adanya peningkatan risiko, sementara studi lainnya menyatakan bahwa konsumsi ikan asin tidak memiliki pengaruh signifikan terhadap kejadian kanker nasofaring. Tujuan: membuktikan konsumsi ikan asin meningkatkan risiko kanker nasofaring. Metode: Tinjauan sistematik dan meta-analisis. Hasil; Dari enam studi, lima studi menunjukkan hasil yang signifikan dan satu studi menunjukkan hasil yang tidak signifikan. Hasil meta-analisis didapatkan nilai p<0,00001 dan crude OR sebesar 1,65. Kesimpulan: Konsumsi ikan asin lebih dari tiga kali dalam satu bulan dapat meningkatkan risiko kanker nasofaring sebesar 1,65 kali. Background: Nasopharyngeal cancer, often referred to as NPC, is a disease of squamous cells on the epithelial layer of the nasopharynx. Consumption of foods contributed to the highest percentage of KNF causes at 35.5%, one of the foods consumed was salted fish. There are differences of opinion between existing studies on the influence of salted fish consumption on the risk of nasopharyngeal cancer. Some studies indicate an increased risk, while other studies state that salted fishing has no significant influence on the incidence of nasopharynx cancer. Objective: Prove that the consumption of salted fish increases the risk of nasopharyngeal cancer. Methods: Systematic review and meta-analysis. Results; Out of six studies, five studies showed significant results and one study showed insignificant results. The meta-analysis resulted in a p<0,00001 and a crude OR of 1.65. Conclusion: Consumption of salted fish more than three times in a month can increase the risk of nasopharyngeal cancer by 1.65 times.

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“…[2,3] Prevalensi KNF sekitar 18-25% pada ras Mongoloid Cina, namun jarang ditemukan di Amerika Utara dan Eropa dengan ras Kaukasoid. [1][2][3] [4,6,7] Rasio penderita KNF lakilaki dan perempuan di RSPAL dr. Ramelan, Surabaya adalah 1,75:1, yang serupa dengan rasio KNF di RSUD Dr. Soetomo, Surabaya dan RSUP Dr. Kariadi, Semarang (2 : 1). Sementara itu, perbandingan laki-laki dan perempuan penderita KNF di seluruh Indonesia adalah 2-3:1; dan di Hongkong 2,5:1.…”

Section: Pendahuluanunclassified

“…Selain itu, individu yang berpendidikan tinggi cenderung melaksanakan pola hidup sehat, sehingga dapat mengurangi faktor resiko KNF dibandingkan individu yang berpendidikan rendah. [6,7,9] Berdasarkan pekerjaan, maka penderita KNF terbanyak di RSPAL Dr Ramelan dan RSUD Dr. Soetomo Surabaya adalah wiraswasta atau karyawan swasta. Sedangkan penelitian di India menunjukkan sebagian besar penderita KNF bekerja sebagai buruh.…”

Section: Pendahuluanunclassified

Karakteristik Klinis Dan Histopatologi Karsinoma Nasofaring Di Rspal Dr. Ramelan, Surabaya

Shoffi¹,

Diarsvitri²

2021

SBJ

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Penelitian ini bertujuan untukmengetahuikrakteristik penderita karsinoma nasofaring (KNF) di Rumah Sakit Pusat Angkatan Laut (RSPAL)dr. Ramelan, Surabaya. Penelitian deskriptif ini menggunakan rekam medis pasien KNF yang baru terdiagnosis di poliklinik THT, RSPAL dr. Ramelan antara Bulan Oktober – Desember 2020. Karakteristik pasien termasuk gejala yang muncul, stadium klinis dan subtipe histopatologi dicatat dan dievaluasi. Dari 22 orang pasien KNF, dua pertiganya laki-laki, lebih dari setengahnya datang dengan keluhan benjolan di leher, dan hampir seluruh pasien sudah dalam stadium lanjut. Temuan histopatologi menunjukkan WHO subtipe 3 adalah tipe KNF yang paling umum. Diagnosis dini merupakan strategi yang penting untuk meningkatkan hasil terapi kanker dengan memberikan perawatan terbaik sedini mungkin

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Prevalence of Nasopharyngeal Carcinoma Patients in Departement of Orl-HNS Hasan Sadikin General Hospital 2010 -2017

Cited by 8 publications

References 19 publications

Assessment of Response to Chemoradiation and Radiation Therapy in Patients with Nasopharyngeal Carcinoma

Assessment of Response to Chemoradiation and Radiation Therapy in Patients with Nasopharyngeal Carcinoma

Konsumsi Ikan Asin Meningkatkan Risiko Kanker Nasofaring: Tinjauan Sistematik dan Meta-analisis

Karakteristik Klinis Dan Histopatologi Karsinoma Nasofaring Di Rspal Dr. Ramelan, Surabaya

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